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Cancer Cell Metabolism

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Insulin-like Growth Factors and Cancer

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Human cancers result from multiple molecular aberrations, which act in concert with both the tumor microenvironment and metabolic macroenvironment to produce the malignant phenotype. Cancer cells exhibit fundamental differences in both anabolic and catabolic metabolism relative to their normal counterparts. Understanding cancer, the metabolic rewiring of cells that drives transformation may provide novel, selective therapeutic opportunities. This altered metabolism of cancer cells appears to be multifaceted involving the energy sensing machinery, as well as fatty acid, amino acid, and glycolytic metabolism. In this chapter, we describe several important features of the differential metabolism in cancer cells that may contribute to the development of a selective growth, proliferation, and survival advantage. We conclude with a summary of pharmaceutical interventions already in clinical use or currently under investigation that target this altered metabolism in human cancers.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Akash Patnaik

  2. Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Akash Patnaik, Jason W. Locasale & Lewis C. Cantley

  3. Department of Systems Biology, Harvard Medical School, Boston, MA, USA

    Akash Patnaik, Jason W. Locasale & Lewis C. Cantley

Authors
  1. Akash Patnaik
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  2. Jason W. Locasale
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  3. Lewis C. Cantley
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Correspondence to Lewis C. Cantley .

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Editors and Affiliations

  1. , Department of Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, NEW YORK, 10029, USA

    Derek LeRoith

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Patnaik, A., Locasale, J.W., Cantley, L.C. (2012). Cancer Cell Metabolism. In: LeRoith, D. (eds) Insulin-like Growth Factors and Cancer. Cancer Drug Discovery and Development. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0598-6_13

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  • DOI: https://doi.org/10.1007/978-1-4614-0598-6_13

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