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Cancer Cell Metabolism

  • Akash Patnaik
  • Jason W. Locasale
  • Lewis C. CantleyEmail author
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

Human cancers result from multiple molecular aberrations, which act in concert with both the tumor microenvironment and metabolic macroenvironment to produce the malignant phenotype. Cancer cells exhibit fundamental differences in both anabolic and catabolic metabolism relative to their normal counterparts. Understanding cancer, the metabolic rewiring of cells that drives transformation may provide novel, selective therapeutic opportunities. This altered metabolism of cancer cells appears to be multifaceted involving the energy sensing machinery, as well as fatty acid, amino acid, and glycolytic metabolism. In this chapter, we describe several important features of the differential metabolism in cancer cells that may contribute to the development of a selective growth, proliferation, and survival advantage. We conclude with a summary of pharmaceutical interventions already in clinical use or currently under investigation that target this altered metabolism in human cancers.

Keywords

Prostate Cancer KRAS Mutation Aerobic Glycolysis Folate Antagonist HCT116 Colon Cancer Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Akash Patnaik
    • 1
    • 2
    • 3
  • Jason W. Locasale
    • 2
    • 3
  • Lewis C. Cantley
    • 2
    • 3
    Email author
  1. 1.Division of Hematology/Oncology, Department of MedicineBeth Israel Deaconess Medical CenterBostonUSA
  2. 2.Division of Signal Transduction, Department of MedicineBeth Israel Deaconess Medical CenterBostonUSA
  3. 3.Department of Systems BiologyHarvard Medical SchoolBostonUSA

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