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Liposomes as Carriers for Controlled Drug Delivery

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Long Acting Injections and Implants

Part of the book series: Advances in Delivery Science and Technology ((ADST))

Abstract

Important recent technological developments in liposome research for parenteral drug delivery are discussed. The chapter is divided into two major sections. The first section provides an overview of liposome physicochemical properties and the mechanism of vesicle formation. Various liposome preparation methods are reviewed, including film hydration method, organic solvent injection method, and reverse phase evaporation. Then several drug encapsulation/loading techniques are discussed. In the second part, the use of liposomes for parenteral drug delivery is discussed with specific examples of marketed products as well as those that are currently under investigation. In particular, the in vivo fate of drug containing liposomes and several successful examples of formulation approaches to alter the drug/liposome in vivo disposition are discussed.

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Abbreviations

DMPC:

Dimyristoyl-phosphatidylcholine

DMPG:

Dqqqimyristoyl-phosphatidylglycerol

DOPE:

Dioleoyl-phosphatidylethanolamine

DPPC:

Dipalmitoyl-phosphatidylcholine

DSPC:

Distearoyl-phosphatidylcholine

DSPG:

Distearyl phosphatidylglycerol

GV:

Giant vesicles

LUV:

Large unilamellar vesicles

MLV:

Multilamellar vesicles

MPS:

Mononuclear phagocyte system

MVV:

Multivesicular vesicles

RES:

Reticuloendothelial system

REV:

Reverse-phase evaporation vesicles

SUV:

Small unilamellar vesicles

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Rd., Storrs, CT, 06269, USA

    Xiaoming Xu & Diane J. Burgess

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  1. Xiaoming Xu
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  2. Diane J. Burgess
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Correspondence to Diane J. Burgess .

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  1. Cuesta Drive 631, Los Altos, 94024, USA

    Jeremy C. Wright

  2. Browns Road 626, Storrs, 06268, Connecticut, USA

    Diane J. Burgess

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© 2012 Controlled Release Society

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Xu, X., Burgess, D.J. (2012). Liposomes as Carriers for Controlled Drug Delivery. In: Wright, J., Burgess, D. (eds) Long Acting Injections and Implants. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-0554-2_11

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