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The Structure of rDNA Chromatin

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The Nucleolus

Part of the book series: Protein Reviews ((PRON,volume 15))

Abstract

The nucleolus is the site of transcription of large tandem repeated arrays of the rDNA which carry the genes for three of the four ribosomal RNAs in eukaryotes. We describe the general genomic features of the rDNA and review what is currently known about its physical organization within the nucleolus. rDNA, like other parts of eukaryotic genomes, is complexed with histones and other proteins to form chromatin, which can adopt at least three functional states that are likely to correlate with physical organization. We review the current state of knowledge of the histones and non-histone proteins in nucleolar chromatin, highlighting both similarities and differences between nucleolar and nuclear chromatin fractions.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, John Innes Centre, Colney, Norwich, UK

    Peter J. Shaw

  2. Department of Botany and Plant Science, Aras de Brun, NUI Galway, Galway, Ireland

    Peter C. McKeown

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  1. Peter J. Shaw
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  2. Peter C. McKeown
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Correspondence to Peter J. Shaw .

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  1. Dept. Biochemistry, University of Mississippi Medical Center, North State St. 2500, Jackson, 39216, Mississippi, USA

    Mark O. J. Olson

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Shaw, P.J., McKeown, P.C. (2011). The Structure of rDNA Chromatin. In: Olson, M. (eds) The Nucleolus. Protein Reviews, vol 15. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0514-6_3

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