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Modulation of T-Cell Mediated Immunity by Cytomegalovirus

  • Chris A. Benedict
  • Ramon Arens
  • Andrea Loewendorf
  • Edith M. Janssen
Chapter

Abstract

The herpesviruses have coevolved with their vertebrate hosts for over one hundred million years (McGeoch et al. 2000), resulting in a finely tuned equilibrium with the immune system. Consequently, all herpesviruses employ a multitude of strategies to modulate the host immune response, facilitating the establishment of lifelong latency and/or persistence in the face of a robust innate and adaptive immune response. Cytomegalovirus (CMV, a β-herpesvirus) is the largest of the herpesviruses, with a genome of ∼230 kB in size encoding >200 open reading frames (orfs). Approximately ∼60% of the encoded genes are not essential for replication of virus in tissue culture where there is no selective pressure from the host immune system and are predicted to perform immunomodulatory functions and facilitate establishment of latency (Murphy et al. 2003; Brocchieri et al. 2005). CMV directly targets dendritic cells (DC) and exploits the DC’s crucial role in the regulation of innate and adaptive anti-viral immune responses to promote replication and establish latency while preventing host pathology.

Keywords

Dendritic Cell HCMV Infection Programme Death Ligand MCMV Infection Herpes Virus Entry Mediator 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media LLC 2012

Authors and Affiliations

  1. 1.Division of Immune RegulationLa Jolla Institute for Allergy and ImmunologyLa JollaUSA
  2. 2.Division of Developmental ImmunologyLa Jolla Institute for Allergy and ImmunologyLa JollaUSA
  3. 3.Division of Molecular ImmunologyLa Jolla Institute for Allergy and ImmunologyLa JollaUSA
  4. 4.Division of Molecular Immunology, Cincinnati Children’s Hospital Research FoundationUniversity of Cincinnati College of MedicineCincinnatiUSA

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