Epilepsy pp 143-152 | Cite as

Simple Partial Seizures

  • David W. McCandless


Simple and complex partial seizures have in common by definition a focal or localized area of onset. A complex partial seizure involves impaired consciousness, whereas in patients exhibiting simple partial seizures do not have impaired consciousness. They are able to answer questions, respond, etc. during the seizure. In contrast, impaired consciousness involves altered awareness/responsiveness. The patient cannot respond to questions or follow directions during the seizure (Dreifuss 1981). Awareness refers to the patient’s contact during the seizure, with the environment, and to recall events.


Temporal Lobe Epilepsy Partial Seizure Partial Epilepsy Complex Partial Seizure Mesial Temporal Lobe Epilepsy 
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  1. Cohen-Gadol, A., et al. (2004) Long term outcome after surgery for focal cortical dysplasia. J. Neurosurg. 101:55–65PubMedCrossRefGoogle Scholar
  2. Brown, W., and Babb, T. (1987) Central pathological considerations of complex partial seizures. In: Hopkins, A., ed. Epilepsy Chapman and Hall, London pp 261-277Google Scholar
  3. Dreifuss, F. (1981) Proposal for a revised clinical and electrographic classification of epileptic seizures. Epilepsia 26:268–278Google Scholar
  4. Ounsted, C., Lindsay, J., and Norman, R. (1966) Biological factors in temporal lobe epilepsy. Clin Dev Med 22:31–33Google Scholar
  5. Astradsson, A., et al. (1998) Rolandic epilepsy: an incidence study in Iceland. Epilepsia 39:884–886PubMedCrossRefGoogle Scholar
  6. Holmes, G. (1986) Partial seizures in children. Pediatr. 77:725–731Google Scholar
  7. Thomas, J., Reagan, T., and Klass, D. (1977) Epilepsia partialis continua: A review of 32 cases. Arch. Neurol. 34:266–275PubMedGoogle Scholar
  8. Deonna, T., et al. (1986) Partial epilepsy in neurologically normal children: clinical syndromes and prognosis. Epilepsia 27:241–247PubMedCrossRefGoogle Scholar
  9. Velisek, L., Vondrickova, R., and Mares, P. (1993) Models of simple partial and absence seizures in freely moving rats Pharm. Biochem. Behav. 45:889–896CrossRefGoogle Scholar
  10. Kohler, C., et al. (2001) Association of fear auras with mood and anxiety disorders after temporal lobectomy. Epilepsia 42:674–681PubMedCrossRefGoogle Scholar
  11. Taylor, D., and Lochery, M. (1987) Temporal lobe epilepsy: origin and significance of simple and complex auras. J. Neurol. Neurosurg. Psychiatr. 50:673–681PubMedCrossRefGoogle Scholar
  12. Gloor, P., et al. (1982) The role of the limbic system in experimental phenomena of temporal lobe epilepsy. Ann Neurol. 12:129–144PubMedCrossRefGoogle Scholar
  13. Gray, T. (1989) Autonomic neuropeptide connections of the amygdala. In Tache, Y., Morley, J., and Brown, M. eds., Neuropeptides and stress. Springer-Verlag, New York pp 92-106CrossRefGoogle Scholar
  14. Chen, C., et al. (2003) Olfactory auras in patients with temporal lobe epilepsy. Epilepsia 44:257–260PubMedCrossRefGoogle Scholar
  15. Penfield, W., and Perot, P. (1963) The brain’s record of auditory and visual experience: a final summary and discussion. Brain 86:595–696PubMedCrossRefGoogle Scholar
  16. Stefan, H., et al. (2002) Autonomic Auras: Left hemispheric predominance of epileptic generators of cold shivers and goose bumps. Epilepsia 43:41–45PubMedCrossRefGoogle Scholar
  17. Palmini, A., and Gloor, P. (1992) The localizing value of auras in partial seizure: a prospective and retrospective study. Neurology 52:801–808Google Scholar
  18. Gupta, A., et al. (1983) Aura in temporal lobe epilepsy: clinical and electrographic correlation. J.Neurol. Neurosurg. Psychiatr. 46:1079–1083PubMedCrossRefGoogle Scholar
  19. Walker, A. (1940) The hypothalamus and pilomotor regulation. Assoc Res Ment Dis Proc. 20:400–415Google Scholar
  20. Smith, W. (1945) The functional significance of the rostal cingulate cortex as revealed by its response to electrical excitation. J. Neurophysiol. 8:241–255Google Scholar
  21. Wieser, H. (1997) Simple partial status epilepticus. In Engel, J., and Pedley, T. eds. Epilepsy: a comprehensive textbook. Phila. Lippincott-Raven pp 709-723Google Scholar
  22. Vander, T., Medvedovsky, M., and Herishanu, Y. (2003) Epilepsia partialis continua possibly caused by cerebellar lesion. The Cerebellum 2:126–128Google Scholar
  23. Norden, A., and Blumenfeld, H. (2002) The role of subcortical structures in human epilepsy. Epil. Behav. 3:219–231CrossRefGoogle Scholar
  24. Striano, P., et al. (2003) Epilepsia partialis continua as a first symptom of multiple sclerosis: electrophysiological study of one case. Mult. Scl. 9:199–203CrossRefGoogle Scholar
  25. Moreau, Th., et al. (1998) Epilepsy in patients with multiple sclerosis: radiological clinical correlations. Epilepsia 39:893–896PubMedCrossRefGoogle Scholar
  26. Sokic, D., et al. (2001) Seizures in multiple sclerosis. Epilepsia 42:72–79PubMedCrossRefGoogle Scholar
  27. Lee, K., Haight, P., and Olejniczak, P. (2000) Epilepsia partialis continua in Creutzfeldt-Jakob disease Acta Neurol Scand 102:398–402Google Scholar
  28. Juul-Jensen, P., and Denny-Brown, D. (1966) Epilepsia partialis continua. Arch Neurol. 15:563–578Google Scholar
  29. Cockerell, O., et al. (1996) Clinical and physiological features of epilepsia partialis continua: cases ascertained in the UK. Brain 119:393–378PubMedCrossRefGoogle Scholar
  30. Baglietto, M., et al. (2009) Epilepsia partialis continua in type 1 diabetes: evolution into epileptic encephalopathy with continuous spike-waves during slow sleep. Neurol. Sci. 30:509–512PubMedCrossRefGoogle Scholar
  31. Brodie, M. (2004) Pregabalin as adjunctive therapy for partial seizures. Epilepsia 45:19–27PubMedCrossRefGoogle Scholar
  32. French, J., et al. (2003) Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures. Neurology 60:1631–1637PubMedGoogle Scholar
  33. Arroyo, S., et al. (2004) Pregabalin add-on treatment: a randomized double blind placebo controlled dose response study in adults with partial seizures. Epilepsia 45:20–27PubMedCrossRefGoogle Scholar
  34. Cohen-Gadol, A., Deluna, M., and Spencer, D. (2004) Partial epilepsy presenting as episodic dyspnea: a specific network involved in limbic seizure propagation. J. Neurosurg. 100: doi: 10.3171/jns.2004.100.3.0565
  35. Rossetti, A., et al. (2005) Simple partial seizures with hemisensory phenomena and dysgeusia: an insular pattern. Epilepsia 46:590–591Google Scholar
  36. Isnard, J., et al. (2004) Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia 45:1079–1090PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • David W. McCandless
    • 1
  1. 1.The Chicago Medical School Department of Cell Biology and AnatomyRosalind Franklin UniversityChicagoUSA

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