Advertisement

Epilepsy pp 127-140 | Cite as

Juvenile Myoclonic Epilepsy in Humans

  • David W. McCandless
Chapter

Abstract

Juvenile myoclonic epilepsy is a common epilepsy, most often seen in the adolescent population. There are two distinct forms of adolescent myoclonic epilepsy: juvenile myoclonic epilepsy and a more severe type called progressive myoclonic epilepsy. Both these forms will be considered in this chapter.

Keywords

Myoclonic Epilepsy Juvenile Myoclonic Epilepsy Myoclonic Seizure Temporal Lobe Epilepsy Patient Idiopathic Generalize Epilepsy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Berkovic, S. (2008) Progressive myoclonic epilepsies. In Pediatric Epilepsy Pellock, J., et al., eds. Demos, NY, pp 367-375Google Scholar
  2. Berkovic, S., et al. (1986) Progressive myoclonus epilepsies: specific causes and diagnosis. N. Eng J. Med. 315:296–305CrossRefGoogle Scholar
  3. Opeskin, K., et al. (2000) Idiopathic generalized epilepsy: lack of significant microdysgenesis. Neurology 55:1101–1106PubMedGoogle Scholar
  4. Hirose, S., et al. (2005) Genetics of idiopatic epilepsy. Epilepsia 46:38–43PubMedCrossRefGoogle Scholar
  5. Panayiotopoulos, C., Obeid, T., and Tahan, A. (1994) Juvenile myoclonic epilepsy: a 5 year prospective study. Epilepsia 35:258–296CrossRefGoogle Scholar
  6. Obeid, T. (1994) Clinical and genetic aspects of juvenile absence epilepsy. J. Neurol. 241:487–491PubMedCrossRefGoogle Scholar
  7. Nair, R., and Thomas, S. (2004) Genetic liability to epilepsy in Kerala State, India. Epil. Res. 62:163–170CrossRefGoogle Scholar
  8. Dhanuka, A., et al. (2001) Juvenile myoclonic epilepsy: a clinical and sleep EEG study. Seizure 10:374–378PubMedCrossRefGoogle Scholar
  9. Bourgeois, B., et al. (1987) Monotherapy with valproate in primary generalized epilepsies. Epilepsia 28:S8-S11PubMedCrossRefGoogle Scholar
  10. Rees, M., et al. (1994) Linkage analysis of idiopathic generalized epilepsy in families of probands with juvenile myoclonic epilepsy and marker loci in the region of EPM 1 on chromosome 21 q. Neuroped 25:20–25CrossRefGoogle Scholar
  11. Pal, D., et al. (2003) BRD2 is a probable major susceptibility gene for common juvenile myoclonic epilepsy. J. Hum. Genet. 73:261–270CrossRefGoogle Scholar
  12. Woermann, F., et al. (1999) Abnormal cerebral structure in juvenile myoclonic epilepsy demonstrated with voxel based analysis of MRI. Brain 122:2101–2108PubMedCrossRefGoogle Scholar
  13. Martinez-Juarez, I., et al. (2006) Juvenile myoclonic epilepsy subsyndromes. Brain 129:1269–1280PubMedCrossRefGoogle Scholar
  14. Shorvon, S., and Walker, M. (2005) Status epilepticus in idiopathic generalized epilepsy. Epilepsia 46:73–79PubMedCrossRefGoogle Scholar
  15. Koepp, M. (2005) Juvenile myoclonic epilepsy-a generalized epilepsy syndrome? Acta Neurol Scand 112:57–62CrossRefGoogle Scholar
  16. Delgado-Escuetta, A., and Enrile-Bacsal, F. (1984) Juvenile myoclonic epilepsy of Janz. Neurol. 34:285–294Google Scholar
  17. Savic, I., et al. (2000) MR spectroscopy shows reduced frontal lobe concentrations of N-acetyl asparate in patients with juvenile myoclonic epilepsy. Epilepsia 41:290–296PubMedCrossRefGoogle Scholar
  18. Woermann, F., et al. (1998) Quantitative MRI in patients with idiopathic generalized epilepsy. Evidence of widespread cerebral structural changes. Brain 121:1661–1667Google Scholar
  19. Pung, T., Schmitz, B. (2006) Circadian rhythm and personality profile in juvenile myoclonic epilepsy. Epilepsia 47:111–114PubMedCrossRefGoogle Scholar
  20. Janz, D,and Christian, W. (1957) Impulsiv-Petit mal. Dtsch Nervenheilkd 176:346–386Google Scholar
  21. Fittipaldi, F., et al. (2001) EEG discharges on awakening: a marker of idiopathic generalized epilepsy. Neurology 56:123–126PubMedGoogle Scholar
  22. Delgado-Escueta, A. (2007) Advances in genetics of juvenile myoclonic epilepsies. Curr. Rev Clin Sci. 7:61–67Google Scholar
  23. Krauss, G., and Morrison, P. (2007) Understanding and treating a channelopathy: severe myoclonic epilepsy of infancy. Neurology 69:233–234PubMedCrossRefGoogle Scholar
  24. Striano, P., et al. (2007) An open label trial of levetiracetam in severe myoclonic epilepsy of infancy. Neurology 69:250–254PubMedCrossRefGoogle Scholar
  25. Meldrum, B., and Rogawski, M. (2007) Molecular targets for antiepileptic drug development. Neurother. 4:18–61CrossRefGoogle Scholar
  26. Piazzini, A., et al. (2008) Frontal cognitive dysfunction in juvenile myoclonic epilepsy. Epilepsy 49:657–662CrossRefGoogle Scholar
  27. Kim, J. et al. (2007) Regional grey matter abnormalities in juvenile myoclonic epilepsy: a voxel based morphometric study. Neuroimage 37:1132–1137PubMedCrossRefGoogle Scholar
  28. Specchio, N., et al. (2008) Effects of levetiracetam on EEG abnormalities in juvenile myoclonic epilepsy. Epilepsia 49:663–669PubMedCrossRefGoogle Scholar
  29. Gelisse, P., et al. (2001) Clinical factors of drug resistance in juvenile myoclonic epilepsy. J. Neurol. Neurosurg. Psychiat. 70:240–243PubMedCrossRefGoogle Scholar
  30. Labate, A., et al. (2007) Usefulness of a morning routine EEG recording in patients with juvenile myoclonic epilepsy. Epil. Res. 77:17–21CrossRefGoogle Scholar
  31. Noachtar, S., et al. (2008) Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology 70:607–616PubMedCrossRefGoogle Scholar
  32. Hirano, Y., et al. (2009) Differentiation of myoclonic seizures in epileptic syndromes: a video polygraphic study of 26 patients. Epilepsia 50:1525–1535PubMedCrossRefGoogle Scholar
  33. Lin, K., et al. (2009) Magnetic resonance spectroscopy reveals an epileptic network in juvenile myoclonic epilepsy. Epilepsia 50:1191–1200PubMedCrossRefGoogle Scholar
  34. Filho, G., et al. (2009) Are personality traits of juvenile myoclonic epilepsy related to frontal lobe dysfunctions? A protein MRS study. Epilepsia 50:1201–1209CrossRefGoogle Scholar
  35. Holmes, M., Quiring, J., and Tucker, D. (2010) Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks. Neuroimage 49:80–93PubMedCrossRefGoogle Scholar
  36. McCormick, D. (2002) Cortical and subcortical generators of normal and abnormal rhythmicity Int. Rev. Neurobiol. 22:2323–2334Google Scholar
  37. Steriade, M. (2003) Neuronal substrate of sleep and epilepsy. Cambridge Univ. Press, Ny pp 215-227Google Scholar
  38. Tae, W., et al. (2008) Cortical thickness abnormality in juvenile myoclonic epilepsy. J. Neurol. 255:561–566PubMedCrossRefGoogle Scholar
  39. Badawy, R., et al. (2010) Can changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy? Epilepsia 51:Google Scholar
  40. Manganotti, P., et al. (2011) Highly focal BOLD activation on functional MRI in a patient with progressive myoclonic epilepsy and diffuse giant somatosensory evoked potentials Epil. Behav. PMID 21339087 Feb 19Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • David W. McCandless
    • 1
  1. 1.The Chicago Medical School Department of Cell Biology and AnatomyRosalind Franklin UniversityChicagoUSA

Personalised recommendations