Epilepsy pp 3-13 | Cite as

World Health Concerns

  • David W. McCandless


The World Health Organization (WHO) estimates that there are 50 million people suffering from epilepsy worldwide. In addition, about 75% or more are living in developing countries, sometimes with suboptimal medical care. It is estimated that 2.4 million new cases occur globally each year, and over half have their fi rst seizure in childhood. Probably 70% of epilepsy patients have a measure of treatment success, allowing many to have essentially normal lives. In third world countries, most epileptics receive no treatment for various reasons, including lack of health care, lack of money, and/or lack of knowledge.


Status Epilepticus Cerebral Malaria Epileptic Patient Epilepsy Patient Complex Partial Seizure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Annegers, J., et al. (1999) The incidence of epilepsy and unprovoked seizures in multiethnic urban health maintenance organization Epilepsia 40:502–506Google Scholar
  2. Carter, J., et al. (2004) Increased prevalence of epilepsy associated with severe falciparum malaria in children Epilepsia 45:978–981Google Scholar
  3. Placencia, M., et al. (1994) The characteristics of epilepsy in a largely untreated population in rural Ecuador J. Neurol, Neurosurg., and Psychiatr. 57:320–325Google Scholar
  4. Wiebe, S., et al. (1999) Burden of epilepsy: the Ontario health survey Canad J Neurol Sci 26:263–270Google Scholar
  5. Watts, A. (1989) A model for managing epilepsy in a rural community Brit Med J 298:805–807Google Scholar
  6. Li, S., Wu, J., and Salzberg, M (2005) The western pacific region and the global campaign against epilepsy Epilepsia 46:64–65Google Scholar
  7. de Boer, H. (2005) Overview and perspectives of employment in people with epilepsy Epilepsia 46:52–54Google Scholar
  8. Ramaratnam, S., and Narasimha, M. (2005) Prevalence and patterns of epilepsy in India Epilepsia 46:89–90Google Scholar
  9. Chisholm, D. (2005) Cost effectiveness of first line antiepileptic drug treatments in the developing world: a population level analysis Epilepsia 46:751–759Google Scholar
  10. Keusch, G., Wilentz, J., and Kleinman, A. (2006) Stigma and global health: developing a research agenda Lancet 367:525–527Google Scholar
  11. Molyneux, M. (2000) Impact of malaria on the brain and its prevention. Lancet 355:671–672PubMedCrossRefGoogle Scholar
  12. Warrell, D., Molyneaux, M., and Beasles, P. (1990) Severe and complicated malaria Trans R Soc Trop Med Hyg 84:1–65Google Scholar
  13. Schmutzhard, E., and Gerstenbrand, F. (1984) Cerebral malaria in Tanzania: its epidemiology, clinical symptoms and neurological long term sequelae in the light of 66 cases. Trans R Soc Trop Med Hyg 78:351–353PubMedCrossRefGoogle Scholar
  14. Dua, T., et al. (2006) Epilepsy care in the world: results of an ILAE/IBE/WHO global campaign against epilepsy survey Epilepsia 47:1225–1231Google Scholar
  15. Theodore, W., et al. (2006) Epilepsy in North America: A report prepared under the auspices of the global campaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization. Epilepsia 47:1700–1722PubMedCrossRefGoogle Scholar
  16. Christian-Herman, J., Emons, M., and George, D. (2004) Effects of generic only drug coverage in a medicare HMO Health Affairs 4:455–468Google Scholar
  17. Kotsopoulos, I., et al. (2002) Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures Epilepsia 43:1402–1409Google Scholar
  18. Ding, D., et al. (2006) Assessing the disease burden due to epilepsy by disability adjusted life year in rural China Epilepsia 47:2032–2037Google Scholar
  19. Food and Agriculture Organization (2006) Available at
  20. Balogou, A., et al. (2007) Management of epilepsy patients in Batamariba district, Togo Acta Neurol Scand 116:211–216CrossRefGoogle Scholar
  21. Jilek, W., and Jilek-Aall, L. (1970) The problem of epilepsy in a rural Tanzanian tribe Afr J Med Sci 1:305–307Google Scholar
  22. Nicoletti, A., et al. (2005) Epilepsy and neurocysticercosis in rural Bolivia: a population based survey Epilepsia 46:1127–1132Google Scholar
  23. Tran, D., et al. (2008) The challenge of epilepsy control in deprived settings: Low compliance and high fatality rates during a community based phenobarbitol program in rural Laos Epilepsia 49:539–540Google Scholar
  24. Tran, D., et al. (2006) Prevalence of epilepsy in a rural district in Lao PDR Neuroepid. 26:109–116Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • David W. McCandless
    • 1
  1. 1.The Chicago Medical School Department of Cell Biology and AnatomyRosalind Franklin UniversityChicagoUSA

Personalised recommendations