Breast Cancer Subtypes: Two Decades of Journey from Cell Culture to Patients
Recent molecular profiling has identified six major subtypes of breast cancers that exhibit different survival outcomes for patients. To address the origin of different subtypes of breast cancers, we have now identified, isolated, and immortalized (using hTERT) mammary stem/progenitor cells which maintain their stem/progenitor properties even after immortalization. Our decade long research has shown that these stem/progenitor cells are highly susceptible to oncogenesis. Given the emerging evidence that stem/progenitor cells are precursors of cancers and that distinct subtypes of breast cancer have different survival outcome, these cellular models provide novel tools to understand the oncogenic process leading to various subtypes of breast cancers and for future development of novel therapeutic strategies to treat different subtypes of breast cancers.
KeywordsBreast Cancer Myoepithelial Cell Breast Cancer Stem Cell Human Mammary Gland Basal Subtype
The authors thank the past and present members of their laboratories that have contributed to work published from our laboratories. Work in our laboratories was supported by the NIH Grants R01CA096844 and R01CA 144027 (VB), and R01CA099163, R01CA116552, R01CA105489, and R01CA087986 (HB) and department of defense breast cancer program W81XWH-07-1-0351 and W81XWH-11-1-0171 (VB), and W81XWH-11-1-0166 (HB) and Eppley Cancer Center Grant.
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