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Comparison of Iterative and Direct Inversion MR Elastography Algorithms

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Mechanics of Biological Systems and Materials, Volume 2

Abstract

Magnetic Resonance Elastography (MRE) is a medical imaging modality which aims to image the mechanical properties of tissue. Tissue stiffness maps can be calculated from measurements of the steady-state mechanical response of the tissue undegoing a low frequency (40-200Hz) mechanical excitation, which are taken using modified magnetic resonance imaging (MRI) sequences. There are two classes of methods to perform this stiffness calculation: Iterative inversion, and Direct inversion. Experiments using gelatin phantoms, consisting of a soft background and stiff inclusion, show that both methods accurately locate the inclusion. Iterative inversion provides better quantitative accuracy when compared to independent measurements using a dynamic mechanical analyzer, however, the computation time is significantly longer than direct inversions (iterative methods take hours, whereas direct inversion take seconds). The decision of which method to use for a given application must be made by weighing up the advantages of fast computation time for direct inversion against the better quantitative accuracy of iterative techniques.

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Authors and Affiliations

  1. Dartmouth College, Hanover, NH, 03755, USA

    M. D. J. McGarry, A. J. Pattison & K. D. Paulsen

  2. University of Canterbury, Christchurch, New Zealand

    E. E. W van Houten

  3. Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA

    J. B. Weaver & K. D. Paulsen

Authors
  1. M. D. J. McGarry
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  2. E. E. W van Houten
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  3. A. J. Pattison
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  4. J. B. Weaver
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  5. K. D. Paulsen
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Editor information

Editors and Affiliations

  1. Society for Experimental Mechanics, School Street 7, BETHEL, 06801-1405, USA

    Tom Proulx

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© 2011 Springer Science+Business Media, LLC

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McGarry, M.D.J., van Houten, E.E.W., Pattison, A.J., Weaver, J.B., Paulsen, K.D. (2011). Comparison of Iterative and Direct Inversion MR Elastography Algorithms. In: Proulx, T. (eds) Mechanics of Biological Systems and Materials, Volume 2. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0219-0_6

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  • DOI: https://doi.org/10.1007/978-1-4614-0219-0_6

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-0218-3

  • Online ISBN: 978-1-4614-0219-0

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