Glaucoma is one of the leading causes of blindness in the world. Evidence suggests that the stress generated in the eye wall by an elevated intraocular pressure plays a role in damaging the visiontransmitting retinal ganglions cells. However, the relationship between the connective tissue’s mechanical properties and how it affects the cellular function is not understood. The purpose of this study was to measure the inflation response of intact C57/BL6 (control) mouse sclera to increases in intraocular pressure, comparing old (11 month) and young (2 month) animals. Mouse eyes were enucleated, mounted by the cornea to a custom fixture, cannulated and immersed in PBS. An active feedback, pressure-controlled syringe pump inflated the cannulated eyes in a series of load-unload and ramp-hold creep tests. A CCD video camera attached to a microscope imaged the expanding scleral surface at 0.5Hz. Scleral displacement was measured with a digital image correlation program. After testing, fresh tissue thickness measurements were taken on scleral slices at multiple locations. An optimized inverse finite element analysis was performed to fit a non-linear anisotropic material model to the experimental data, and material parameters are compared between groups.
- Optic Nerve Head
- Scleral Tissue
- Inverse Finite Element
- Inverse Finite Element Method
- Inflation Response
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, access via your institution.
Tax calculation will be finalised at checkout
Purchases are for personal use onlyLearn about institutional subscriptions
Unable to display preview. Download preview PDF.
Burgoyne CF, Downs JC, Bellezza AJ, Suh JKF, Hart RT, The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of iop-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage, Prog Ret Eye Res, 24, 39–73 2005.
Ethier CR, Predicted outcome from hypotensive therapy for glaucomatous optic neuropathy, Can J Ophthalmol, 41, 9–11, 2006.
Nickells RW, From ocular hypertension to ganglion cell death: a theoretical sequence of events leading to glaucoma, Can J Ophthalmol, 42l, 278–287, 2007.
Downs JC, Thomas KA, Hart RT, Burgoyne CF, Elastic and viscoelastic material properties of peripapillary sclera in normal and early glaucomatous monkey eyes, ARVO Abstract Invest Ophthalmol Vis Sci 42, S831 2001.
Quigley HA, Broman AT, The number of people with glaucoma worldwide in 2010 and 2020. British J. Ophthalmol, 90, 262–267, 2006.
Hattenhauer MG, Johnson DH, Ing H, Herman DC, Hodge DO, Yawn BP, Butterfield LC, Gray DT, The probability of blindness from open angle glaucoma, Ophthalmol, 85, 1277–1282, 2001.
Myers KM, Cone FE, Quigley HA, Gelman S, Pease ME, Nguyen TD, The in vitro response of mouse sclera, Exp Eye Res, 91, 6, 866–875, 2010.
Nguyen TD, Boyce BL, An Inverse Finite Element for Determining the Anisotropic Properties of the Cornea, Biomech Model Mechanbiol, DOI: 10.1007/s10237-010-0237-3ng, 2010.
Gelman S, Cone FE, Pease ME, Nguyen TD, Myers K, Quigley HA, The presence and distribution of elastin in the posterior and retrobulbar regions of the mouse eye, Exp Eye Res, 90, 2, 210–215, 2010.
Editors and Affiliations
© 2011 Springer Science+Business Media, LLC
About this paper
Cite this paper
Myers, K.M., Cone, F., Quigley, H., Nguyen, T.D. (2011). The Scleral Inflation Response of Mouse Eyes to Increases in Pressure. In: Proulx, T. (eds) Mechanics of Biological Systems and Materials, Volume 2. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0219-0_11
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-0218-3
Online ISBN: 978-1-4614-0219-0