The Fine Structure of Slow-Wave Sleep Oscillations: from Single Neurons to Large Networks
This chapter reviews experiments, analyses and models of neuronal activity in the thalamus and cerebral cortex during wake and sleep states. The emphasis is on how the microscopic (units, intracellular) and macroscopic (LFPs, EEG) activity organizes within the different states. In a first part, the correspondence between electroencephalogram (EEG) oscillations and neuronal activity is reviewed. Two types of oscillations are then examined in more detail: spindle (7–14 Hz) and slow (0.1–4 Hz) oscillations. For each, experiments and models are contrasted. Implications of these experimental and modeling results onto the role of slow-wave sleep in consolidating memories are discussed.
KeywordsSlow Wave Slow Oscillation Thalamic Neuron Synaptic Interaction Natural Sleep
Research supported by CNRS, ANR (HR-CORTEX grant), the European Community (FET grants FACETS FP6-015879, BRAINSCALES FP7-269921) and the NIH (R01EY020765).
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