The Fine Structure of Slow-Wave Sleep Oscillations: from Single Neurons to Large Networks
This chapter reviews experiments, analyses and models of neuronal activity in the thalamus and cerebral cortex during wake and sleep states. The emphasis is on how the microscopic (units, intracellular) and macroscopic (LFPs, EEG) activity organizes within the different states. In a first part, the correspondence between electroencephalogram (EEG) oscillations and neuronal activity is reviewed. Two types of oscillations are then examined in more detail: spindle (7–14 Hz) and slow (0.1–4 Hz) oscillations. For each, experiments and models are contrasted. Implications of these experimental and modeling results onto the role of slow-wave sleep in consolidating memories are discussed.
KeywordsDepression Coherence Noradrenaline Acetylcholine Ketamine
Research supported by CNRS, ANR (HR-CORTEX grant), the European Community (FET grants FACETS FP6-015879, BRAINSCALES FP7-269921) and the NIH (R01EY020765).
- Berger H (1929) Über den zeitlichen verlauf der negativen schwankung des nervenstroms. Arch Ges Physiol 1:173 Google Scholar
- Destexhe A (1992) Nonlinear dynamics of the rhythmical activity of the brain. PhD thesis, Université Libre de Bruxelles, Brussels, Belgium. http://cns.iaf.cnrs-gif.fr/alain_thesis.html
- Destexhe A, Sejnowski TJ (2001) Thalamocortical Assemblies. Monographs of the Physiological Society. Oxford University Press, London Google Scholar
- Scheibel ME, Scheibel AB (1966) Patterns of organization in specific and nonspecific thalamic fields. In: DA P, M Y (eds) The thalamus. Columbia University Press, New York, pp 13–46 Google Scholar
- Steriade M (2003) Neuronal substrates of sleep and epilepsy. Cambridge University Press, Cambridge Google Scholar
- Steriade M, Jones EG, McCormick DA (1997) Thalamus. Elsevier, Amsterdam Google Scholar