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Complement Involvement in Neovascular Ocular Diseases

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Current Topics in Innate Immunity II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 946))

Abstract

Pathological neovascularization (NV) is a hallmark of late stage neovascular age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinopathy of prematurity (ROP). There is accumulating evidence that alterations in inflammatory and immune system pathways that arise from genetic differences, injury, and disease can predispose individuals to retinal neovascular eye diseases. Yet the mechanism of disease progression with respect to the complement system in these maladies is not fully understood. Recent studies have implicated the complement system as an emerging player in the etiology of several retinal diseases. We will summarize herein several of the complement system pathways known to be involved in ocular neovascular pathologies. Current treatment for many neovascular eye diseases focuses on suppression of NV with laser ablation, photodynamic therapy, or anti-VEGF angiogenic inhibitors. However, these treatments do not address the underlying cause of many of these diseases. A clear understanding of the cellular and molecular mechanisms could bring a major shift in our approach to disease treatment and prevention.

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Acknowledgments

This work was generously supported by the March of Dimes Foundation (Grant No. 5-FY09-535), National Institutes of Health Core Grant (P30EY014104) and Research to Prevent Blindness Unrestricted Grant.

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Authors and Affiliations

  1. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Angiogenesis Laboratory, Harvard Medical School, 02114, Boston, MA, USA

    Ryoji Yanai, Aristomenis Thanos & Kip M. Connor

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  1. Ryoji Yanai
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  2. Aristomenis Thanos
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  3. Kip M. Connor
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Correspondence to Kip M. Connor .

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Editors and Affiliations

  1. Department Of Pathology Laboratory Of, Medicine, University Of Pennsylvania, Johnson Pavilion 410, Philadelphia, 19104, Pennsylvania, USA

    John D. Lambris

  2. Health Sciences Center, University of Louisville, Louisville, 40292, Kentucky, USA

    George Hajishengallis

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Yanai, R., Thanos, A., Connor, K.M. (2012). Complement Involvement in Neovascular Ocular Diseases. In: Lambris, J., Hajishengallis, G. (eds) Current Topics in Innate Immunity II. Advances in Experimental Medicine and Biology, vol 946. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-0106-3_10

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