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Immune Surveillance and Tumor Evasion

  • M. Katherine Jung
Chapter

Abstract

Tumors are composed of heterogeneous cell types, both diverse transformed cells of the tissue of origin and a variety of stromal cells. The tumor cells themselves differ in the degree of aneuploidy, the number and identity of mutations, the extent of genomic instability, the expression of surface antigens, and the capacity to express cytokines, growth factors, proteases, and angiogenic factors. The stromal cells include fibroblasts, an assortment of leukocytes and lymphocytes, and often cell types that make up blood vessels. Ongoing reciprocal interactions between tumor cells and stromal cells affect the establishment, progression, and maintenance of cancer, with immune cells in particular mediating antitumor surveillance (Fig. 10.1). This chapter explores the details of immune surveillance, discusses the mechanisms by which tumors evade this surveillance, and explores the impact of alcohol on both.

Keywords

Vascular Endothelial Growth Factor Natural Killer Cell Immune Surveillance Chronic Alcohol Natural Killer Cell Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

B cell

Bone marrow-derived lymphocyte

IFN

Interferon

IL

Interleukin

MDSC

Myeloid-derived suppressor cells

MHC

Major histocompatibility complex

NFκB

Nuclear factor kappa-light-chain-enhancer of ­activated B cells

NK

Natural killer (cells)

NKT

Natural killer T (cells)

STAT

Signal transducer and activator of transcription

T cell

Thymus-derived lymphocyte

TAP

Transporter associated with antigen processing

TGFβ

Transforming growth factor beta

Th1 and Th2

CD4+ T helper cells

TNFα

Tumor necrosis factor alpha

Tregs

Regulatory T cells

VEGF

Vascular endothelial growth factor

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Metabolism and Health EffectsNational Institute on Alcohol Abuse and Alcoholism, National Institutes of HealthBethesdaUSA

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