Mammary Gland

  • Dale S. Huff
  • Dale S. Huff
Chapter

Abstract

The prenatal and neonatal development of the mammary gland occurs in three stages: 1) the primordia from 6 to 8 weeks postmenstrual age; 2) the nipple from 8 to 19 weeks; and 3) the ducts of the mammary gland proper from 19 weeks to the neonatal period. The developing breast is composed of specialized epithelium and mesenchyme. The specialized epithelium will form the ectodermal nipple and the mammary ducts. The specialized mesenchyme will form the stroma and smooth muscle of the nipple and areola, the intralobular stroma, and the interlobular septa, as well as the supporting connective tissues including the capsule, Cooper ligaments, and pectoral ligaments. Cooper ligaments anchor the breast to the overlying dermis. Pectoral ligaments anchor the breast to the underlying pectoralis fascia. Interactions between the mesenchyme and epithelium result in the synchronous differentiation of the epithelial basal cells into myoepithelium and the mesenchyme into its various components.

Keywords

Luminal Androgen Prolactin Crest Nipple 

References

  1. 1.
    O’Rahilly R, Muller F: The origin of the ectodermal ring in staged human embryos of the first five weeks. Acta Anat 1958, 122:145–157.CrossRefGoogle Scholar
  2. 2.
    Hughes ESR: The development of the mammary gland. Ann R Coll Surg 1950, 6:3–23.Google Scholar
  3. 3.
    Friedrichs N, Steiner S, Buettner R, Knoepfle G: Immunohis­tochemical expression patterns of AP2a and AP2g in the developing fetal human breast. Histopathology 2007, 51: 814–823.PubMedCrossRefGoogle Scholar
  4. 4.
    Sternlicht MD: Key stages in mammary gland development. The cues that regulate ductal branching morphogenesis. Breast Cancer Res 2006, 8:201–211.PubMedCrossRefGoogle Scholar
  5. 5.
    Jolicouer F, Gaboury LA, Oligny LL: Basal cells of second trimester fetal breasts: immunohistochemical study of myoepithelial precursors. Pediatr Dev Patho 2003, 6:398–413.CrossRefGoogle Scholar
  6. 6.
    Jolicouer F: Intrauterine breast development and mammary myoepithelial lineage. J Mammary Gland Biol Neoplasia 2006, 10: 199–210.CrossRefGoogle Scholar
  7. 7.
    McKiernan JF, Hull D: Breast development in the newborn. Arch Dis Child 1981, 56:525–529.PubMedCrossRefGoogle Scholar
  8. 8.
    Anbazhagan R, Bartek J, Monaghan P, Gusterson BA: Growth and development of the human infant breast. Am J Anat 1995, 192:407–417.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Dale S. Huff
    • 1
  • Dale S. Huff
    • 2
  1. 1.Department of Pathology and Laboratory MedicineThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineThe University of Pennsylvania School of MedicinePhiladelphiaUSA

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