Bone Marrow

  • Michele E. Paessler
  • Michele E. Paessler
  • Scott Bourne


In the developing embryo and fetus, hematopoiesis is a dynamic process that starts in the yolk sac, continues in the liver, and finally stabilizes in the bone marrow. The role of the spleen in fetal hematopoiesis is controversial and is discussed in Chapter 23. Starting at 11 weeks gestation, hematopoiesis begins in the bone marrow and will remain there for the rest of adult life. Hematopoiesis begins with self-renewing multipotent stem cells that give rise to committed progenitor cells, which ultimately differentiate into the cells that circulate in the peripheral blood.


Erythroid Cell Erythroid Precursor Blood Island Bony Trabecula Congenital Dyserythropoietic Anemia 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Michele E. Paessler
    • 1
  • Michele E. Paessler
    • 2
  • Scott Bourne
    • 3
  1. 1.Clinical Immunology and Flow Cytometry Laboratory, Department of Pathology and Laboratory MedicineThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  3. 3.Department of PathologyPhysicians Regional Medical CenterNaplesUSA

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