In the developing embryo and fetus, hematopoiesis is a dynamic process that starts in the yolk sac, continues in the liver, and finally stabilizes in the bone marrow. The role of the spleen in fetal hematopoiesis is controversial and is discussed in Chapter 23. Starting at 11 weeks gestation, hematopoiesis begins in the bone marrow and will remain there for the rest of adult life. Hematopoiesis begins with self-renewing multipotent stem cells that give rise to committed progenitor cells, which ultimately differentiate into the cells that circulate in the peripheral blood.
KeywordsMigration Anemia Crest Erythropoietin Mast
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