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Adrenal Gland

  • Linda M. Ernst
Chapter

Abstract

The fetal adrenal gland is structurally significantly different from the adult adrenal gland. One of the obvious differences noted when performing fetal dissection is that the fetal adrenal gland is proportionately large, appearing nearly as large as the kidney in the early midtrimester. The normal adrenal gland weight in adults is about 5% of the normal kidney weight and, combined, the adrenals represent 0.02% of total adult body weight. The adrenal/kidney weight and adrenal/body weight ratios in fetuses are much higher throughout fetal life (see Fig. 18-1) [1,2]. The bulk of the fetal adrenal gland is largely due to the presence of the fetal adrenal cortex, or fetal zone, that produces dehydroepiandrosterone (DHEA) and DHEA-sulfate. These weak androgens are important precursors of placental estrogens. Later in gestation the fetal adrenal gland will also produce aldosterone and cortisol.

Keywords

Adrenal Gland Chromaffin Cell Fetal Life Zona Glomerulosa Zona Fasciculata 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Hansen K, Sung CJ, Huang C, et al.: Reference values for second trimester fetal and neonatal organ weights and measurements. Pediatr Dev Pathol 2003, 6:160–167.PubMedCrossRefGoogle Scholar
  2. 2.
    Siebert J: Perinatal, fetal and embryonic autopsy. In Potter’s Pathology of the Fetus, Infant, and Child, edn 2. Edited by Gilbert-Barness E. Philadelphia: Mosby Elsevier; 2007:726–727.Google Scholar
  3. 3.
    Rainey WE, Rehman KS, Carr BR: Fetal and maternal adrenals in human pregnancy. Obstet Gynecol Clin North Am 2004, 31:817–835, x.PubMedCrossRefGoogle Scholar
  4. 4.
    Sadler TW, Langman J: Langman’s Medical Embryology, edn 11. Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins; 2010.Google Scholar
  5. 5.
    Schoenwolf GC, Larsen WJ: Larsen’s Human Embryology, edn 4. Philadelphia, PA: Elsevier/Churchill Livingstone; 2009.Google Scholar
  6. 6.
    Hervonen A: Development of catecholamine—storing cells in human fetal paraganglia and adrenal medulla. A histochemical and electron microscopical study. Acta Physiol Scand Suppl 1971, 368:1–94.PubMedGoogle Scholar
  7. 7.
    Turkel SB, Itabashi HH: The natural history of neuroblastic cells in the fetal adrenal gland. Am J Pathol 1974, 76:225–244.PubMedGoogle Scholar
  8. 8.
    Mesiano S, Jaffe RB: Developmental and functional biology of the primate fetal adrenal cortex. Endocr Rev 1997, 18:378–403.PubMedCrossRefGoogle Scholar
  9. 9.
    Pepe GJ, Albrecht ED: Regulation of the primate fetal adrenal cortex. Endocr Rev 1990, 11:151–176.PubMedCrossRefGoogle Scholar
  10. 10.
    Suzuki T, Sasano H, Takeyama J, et al.: Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol (Oxf) 2000, 53:739–747.CrossRefGoogle Scholar
  11. 11.
    Coupland RE: The natural history of the chromaffin cell—­twenty-five years on the beginning. Arch Histol Cytol 1989, 52:331–341.CrossRefGoogle Scholar
  12. 12.
    Beckwith JB, Perrin EV: In situ neuroblastomas: a contribution to the natural history of neural crest tumors. Am J Pathol 1963, 43:1089–1104.PubMedGoogle Scholar
  13. 13.
    Shimada H: In situ neuroblastoma: an important concept related to the natural history of neural crest tumors. Pediatr Dev Pathol 2005, 8:305–306.PubMedCrossRefGoogle Scholar
  14. 14.
    Vestfrid MA: Ectopic adrenal cortex in neonatal liver. Histopathology 1980, 4:669–672.PubMedCrossRefGoogle Scholar
  15. 15.
    Drut R, Quijano G, Altamirano ME, et al.: Vascular malformation and choroid plexus adrenal heterotopia: new findings in Beckwith-Wiedemann syndrome? Fetal Pediatr Pathol 2006, 25:191–197.PubMedCrossRefGoogle Scholar
  16. 16.
    Kepes JJ, O’Boynick P, Jones S, et al.: Adrenal cortical adenoma in the spinal canal of an 8-year-old girl. Am J Surg Pathol 1990, 14:481–484.PubMedCrossRefGoogle Scholar
  17. 17.
    Mitchell A, Scheithauer BW, Sasano H, et al.: Symptomatic intradural adrenal adenoma of the spinal nerve root: report of two cases. Neurosurgery 1993, 32:658–661; discussion 61–62.PubMedCrossRefGoogle Scholar
  18. 18.
    Marchevsky AM: Lung tumors derived from ectopic tissues. Semin Diagn Pathol 1995, 12:172–184.PubMedGoogle Scholar
  19. 19.
    Guschmann M, Vogel M, Urban M: Adrenal tissue in the placenta: a heterotopia caused by migration and embolism? Placenta 2000, 21:427–431.PubMedCrossRefGoogle Scholar
  20. 20.
    Labarrere CA, Caccamo D, Telenta M, et al.: A nodule of adrenocortical tissue within a human placenta: light microscopic and immunocytochemical findings. Placenta 1984, 5:139–143.PubMedCrossRefGoogle Scholar
  21. 21.
    Beckwith J: Macroglossia, omphalocele, adrenal cytomegaly, gigantism, and hyperplastic visceromegaly. Birth Defects 1969, 5:188–196.Google Scholar
  22. 22.
    Wiedemann HR: Familial malformation complex with umbilical hernia and macroglossia–a “new syndrome”? J Genet Hum 1964, 13:223–232.PubMedGoogle Scholar
  23. 23.
    Mamelle JC, David M, Riou D, et al.: Congenital adrenal ­hypoplasia of cytomegalic type. Recessive, sex-linked form. Apropos of 3 cases [in French]. Arch Fr Pediatr 1975, 32:139–159.PubMedGoogle Scholar
  24. 24.
    de Sa DJ: Adrenal changes in chorioamnionitis. Arch Dis Child 1974, 49:149–151.PubMedCrossRefGoogle Scholar
  25. 25.
    de Sa DJ: Stress response and its relationship to cystic (pseudofollicular) change in the definitive cortex of the adrenal gland in stillborn infants. Arch Dis Child 1978, 53:769–776.PubMedCrossRefGoogle Scholar
  26. 26.
    Lacson A, Desa DJ: Endocrine glands. In Potter’s Pathology of The Fetus, Infant, and Child, edn 2. Edited by Gilbert-Barness E. Philadelphia: Mosby Elsevier; 2007:1630.Google Scholar
  27. 27.
    Rodin AE, Hsu FL, Whorton EB: Microcysts of the permanent adrenal cortex in perinates and infants. Arch Pathol Lab Med 1976, 100:499–502.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Linda M. Ernst
    • 1
  1. 1.Department of PathologyNorthwestern University Feinberg School of MedicineChicagoUSA

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