Epididymis

  • Dale S. Huff
  • Dale S. Huff
  • Eduardo D. Ruchelli
  • Eduardo D. Ruchelli
Chapter

Abstract

The primary function of the epididymis is to provide a conduit for the transport of sperm and seminiferous fluid from the rete testis to the vas deferens. However, the epididymis performs much more elaborate functions including the resorption of some of the fluid by the head of the epididymis, final maturation and development of motility in the body, and storage of sperm in the tail. Performance of these functions requires the development of an elaborate rostral to caudal gradient of epithelial specialization from the efferent ductules to the beginning of the vas deferens, which is not completed until puberty. Knowledge of the changing fetal histology described in this chapter aids in the understanding of the congenital anomalies of the epididymis that are seen in association with cryptorchidism [1], renal and ureteral anomalies, cystic fibrosis, and other underlying conditions.

Keywords

Estrogen Androgen Inhibin Cryptorchidism 

References

  1. 1.
    De Miguel MP, Marino JM, Gonzalez-Peramato P, et al.: Epididymal growth and differentiation are altered in human cryptorchidism. J Androl 2001, 22:212–225.PubMedGoogle Scholar
  2. 2.
    Felix W: The development of the urinogenital organs. In Human Embryology. Edited by Keibel F, Mall FP. Philadelphia: JB Lippincott; 1912:752–979.Google Scholar
  3. 3.
    Hadziselimovic F: Cryptorchidism. Berlin: Springer-Verlag; 1983.Google Scholar
  4. 4.
    Hadziselimovic F, Kruslin E: The role of the epididymis in descensus testis and the topographical relationship between the testis and epididymis from the sixth month of pregnancy until immediately after birth. Anat Embryol (Berl) 1979,155:191–196.CrossRefGoogle Scholar
  5. 5.
    Dacheux JL, Belghazi M, Lanson Y, Dacheux F: Human epididymal secretome and proteome. Mol Cell Endocrinol 2006, 250:36–42.PubMedCrossRefGoogle Scholar
  6. 6.
    Yeung CH, Cooper TG, Bergmann M, Schulze H: Organization of tubules in the human caput epididymidis and the ultrastructure of their epithelia. Am J Anat 1991, 191:261–279.PubMedCrossRefGoogle Scholar
  7. 7.
    Trainer T: The testis and excretory duct system. In Histology for Pathologists, edn 3. Edited by Mills SE. Philadelphia: Lippincott Williams & Wilkins; 2007:943–963.Google Scholar
  8. 8.
    Ladman A: The male reproductive system. In Histology, edn 3. Edited by Greep RO, Weiss L. New York: McGraw-Hill; 1973:847–890.Google Scholar
  9. 9.
    Nistal M, Gonzalez-Peramato P, De Miguel MP: Immunodetection of inhibin in the human testis and epididymis during normal development and in non-tumoural testicular lesions. Reprod Fertil Dev 2010, 22:558–563.PubMedCrossRefGoogle Scholar
  10. 10.
    Shapiro E, Huang H, Masch RJ, et al.: Immunolocalization of ­androgen receptor and estrogen receptors alpha and beta in human fetal testis and epididymis. J Urol 2005, 174:1695–1698; ­discussion 8.PubMedCrossRefGoogle Scholar
  11. 11.
    Regadera J, Cobo P, Paniagua R, et al.: Immunohistochemical and semiquantitative study of the apical mitochondria-rich cells of the human prepubertal and adult epididymis. J Anat 1993, 183:507–514.PubMedGoogle Scholar
  12. 12.
    Joseph A, Yao H, Hinton BT: Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns. Dev Biol 2009, 325:6–14.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Dale S. Huff
    • 1
  • Dale S. Huff
    • 2
  • Eduardo D. Ruchelli
    • 1
  • Eduardo D. Ruchelli
    • 3
  1. 1.Department of Pathology and Laboratory MedicineThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA
  2. 2.Department of Pathology and Laboratory MedicineThe University of Pennsylvania School of MedicinePhiladelphiaUSA
  3. 3.Department of Pathology and Laboratory MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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