Mouse Mammary Tumor Virus and Cancer

Chapter
Part of the Current Cancer Research book series (CUCR)

Abstract

The retrovirus mouse mammary tumor virus (MMTV) was discovered in the 1930s as a milk-transmitted agent that causes breast cancer in mice. MMTV causes mammary tumors by insertional activation or mutation of cellular oncogenes. Some of the oncogenes activated by MMTV insertion have been also associated with human breast cancer. In addition to allowing the identification of oncogenes associated with this disease, the MMTV long terminal repeat has been used to create numerous strains of transgenic mice with genetic predisposition to breast cancer. Thus, this virus has provided one of the most useful models for understanding human breast cancer.

Keywords

Lymphoma Lactate Cage Tyrosine Leukemia 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of Microbiology, Abramson Cancer CenterUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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