Surgical Treatment of Cushing’s Disease

Part of the Endocrine Updates book series (ENDO, volume 31)


Modern transsphenoidal surgery for Cushing’s disease is usually curative, achieving durable remission in 70–90% of cases. Comparison of remission and recurrence rates between series in the literature is difficult as many employ different remission criteria. Complication rates are low, but include hypopituitarism, diabetes insipidus, and CSF rhinorhhea. Improved remission rates can be obtained with early re-exploration after initial unsuccessful procedures, and reoperation remains an option after recurrence. This chapter reviews current surgical techniques, including microscopic and endoscopic approaches.


Adrenocorticotropic hormone Hypercortisolemia Hypophysectomy Pituitary adenoma Transsphenoidal surgery 


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of NeurosurgeryMassachusetts General HospitalBostonUSA
  2. 2.Department of NeurosurgeryMassachusetts General Hospital and Harvard Medical SchoolBostonUSA

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