Abstract
The clinical condition of Down syndrome was first described in 1866 in a paper published in the London Hospital Reports by the British neurologist, Dr. John Langdon Down, the clinical syndrome, however, has been with us for centuries, as indicated by 15th- and 17th-century paintings of children who appear to have phsyical characteristics of this syndrome (Patterson, 1987; Smith et al., 1976). The past literature dealing with theories of the etiology of this chromosomal syndrome is extensive (Pueschel & Steinberg, 1980). However, it was not until the cytogenetics work in the 1950s of Lejeune et al. that we had any real insight into the etiology of this syndrome. What was demonstrated was an extra number 21 chromosome in individuals with the clinical presentation of Down syndrome.
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Van Dyke, D.C., Heide, F. (1990). Interdisciplinary Approaches. In: Van Dyke, D.C., Lang, D.J., Heide, F., van Duyne, S., Soucek, M.J. (eds) Clinical Perspectives in the Management of Down Syndrome. Disorders of Human Learning, Behavior, and Communication. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9644-4_14
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DOI: https://doi.org/10.1007/978-1-4613-9644-4_14
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