Common Medical Problems

  • Don C. Van Dyke
  • David J. Lang
  • John D. Miller
  • Frances Heide
  • Susan van Duyne
  • Hyejung Chang
Part of the Disorders of Human Learning, Behavior, and Communication book series (HUMAN LEARNING)


The medical problems associated with Down syndrome have a significant impact on the delivery of all other services, whether social, educational, or developmental. The problems can be acute but are most commonly chronic, demonstrating wide variability and affecting multiple organ systems.


Hearing Loss Down Syndrome Patent Ductus Arteriosus Ventricular Septal Defect Congenital Hypothyroidism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bennett, F.C., McClelland, S., Kriesgsmann, E.A., Andrus, L.B., & Sells, C.J. (1983). Vitamin and mineral supplementation in Down’s syndrome. Pediatrics, 72(5), 707–713.PubMedGoogle Scholar
  2. Burgio, G.R., Ugazio, A., Nespoli, L., & Maccario, R. (1983). Down syndrome: A model of immunodeficiency. Birth Defects (Original article series), 19 (3), 325–327Google Scholar
  3. Cutler, A.T., Benezra-Obeiter, R., & Brink, S.J. (1986). Thyroid function in young children. American Journal of Diseases of Children, 140, 479–483.PubMedGoogle Scholar
  4. de la Cruz, F.F., & Gerald, P.S. (Eds.). (1981). Trisomy 21 (Down syndrome)Research Perspective .Baltimore: University Park Press.Google Scholar
  5. Eissler, R., & Longenecker, L.P. (1962). The common eye findings in mongolism. American Journal of Ophthalmology, 54, 398–406.PubMedGoogle Scholar
  6. Fekete, G., Kulcsar, G., Dann, P., Nasz, I., Schuler, D., & Dobos, M. (1982). Immunological and virological investigations in Down’s syndrome. European Journal of Pediatrics, 138, 59–62.PubMedCrossRefGoogle Scholar
  7. Fidone, G.S. (1986). Degenerative cervical arthritis in Down syndrome. New England Journal of Medicine, 312 (5), 320.Google Scholar
  8. Fort, P., Lifschitz, F., Bellisario, R., Davis, J., Lanes, R., Pugliese, M., Richman, R., Post, E.M., & David, R. (1984). Abnormalities of thyroid function in infants with Down syndrome. Journal of Pediatrics, 104 (4), 545–549.PubMedCrossRefGoogle Scholar
  9. Greenwood, R.D., & Nadas, A.S. (1976). The clinical course of cardiac disease in Down’s syndrome. Pediatrics, 58(6), 893–897.PubMedGoogle Scholar
  10. Harris, F., & Koutsoulieris, E. (1967). Hypothyroidism due to autoimmune thyroiditis in a young child with Down syndrome. Archives of Disease of Childhood, 42, 449–452.CrossRefGoogle Scholar
  11. Hiles, D.A., Hoyme, S.H., & McFarlane, F. (1974). Down’s syndrome and strabismus. American Orthoptic Journal, 24, 63–68.PubMedGoogle Scholar
  12. Hollingsworth, D.E., McKean, H.E., & Roekel, I. (1974). Goiter, immunological observations and thyroid function tests in Down syndrome. American Journal of Diseases of Children, 127, 524–527.PubMedGoogle Scholar
  13. Kilcoyne, R.F., &Taybi, H. (1970). Conditions associated with congenital megacolon. American Journal of Roentgen Radium Thermal Nuclear Medicine, 108, 615–620.Google Scholar
  14. Knox, G.E., & Bensei, R.W. (1972). Gastrointestinal malformations in Down syndrome. Minnesota Medicine, 55, 542–545.PubMedGoogle Scholar
  15. Lang, D.J., Van Dyke, D.C., Heide, F., & Lowe, P.L. (1987). Hypospadia and urethral abnormalities in Down syndrome. Clinical Pediatrics, 26 (1), 40–42.PubMedCrossRefGoogle Scholar
  16. Levin, S., Nir, E., & Mogilner, B.M. (1975). T-system immune deficiency in Down’s syndrome. Pediatrics, 56, 123–126.PubMedGoogle Scholar
  17. Miller, R.W. (1970). Neoplasia and Down’s syndrome. Annual New York Academy of Science, 171, 637–644.CrossRefGoogle Scholar
  18. Murdoch, J.C., et al. (1977). Thyroid function in adults with Down syndrome. Journal of Clinical Endocrinology, 44, 453–458.CrossRefGoogle Scholar
  19. Park, S.C., Mathews, R.A., Zuberbuhler, J.R., Rowe, R.D., Neches, W.H., & Lenox, C.C. (1977). Down syndrome with congenital heart disease. American Journal of Diseases of Children, 131, 29–33.PubMedGoogle Scholar
  20. Pueschel, S.M., & Pezzullo, J.C. (1985). Thyroid dysfunction in Down syndrome. American Journal of Diseases of Children, 139, 636–639.PubMedGoogle Scholar
  21. Pueschel, S.M., & Rynders, T.E. (1982). Down syndrome: Advances in biomedicine and the behavioral sciences (pp. 243–246). Mass: Cambridge, Ware Press.Google Scholar
  22. Pueschel, S.M., Tingey, C., Rynders, J.E., Crocker, A.C., & Crutcher, D.M. (1987). New perspectives on Down syndrome. Baltimore: Paul H. Brookes.Google Scholar
  23. Quinn, M.W. (1980). Down syndrome and hypothyroidism. Journal of Medical Science, 1, 19–22.Google Scholar
  24. Resner, F., & Lee, S.L. (1972). Down’s syndrome and acute leukemia: Myeloblastic or lymphocytic? Report of forty-three cases and review of the literature. American Journal of Medicine, 53 (2), 203–218.CrossRefGoogle Scholar
  25. Robinson, L.L., et al. (1984). Down syndrome and acute leukemia in children: A ten-year retrospective survey from children’s cancer study group. Journal of Pediatrics, 105, 235–242.CrossRefGoogle Scholar
  26. Rowe, D. (1962). Cardiac malformation in mongolism. American Heart Journal, 64, 567–569.PubMedCrossRefGoogle Scholar
  27. Rowe, R.D., & Uchida, I.A. (1961). Cardiac malformation in mongolism: A prospective study of 184 mongoloid children. American Journal of Medicine, 31, 726–735.PubMedCrossRefGoogle Scholar
  28. Sare, Z., Recvalcaba, R.H.A., & Kelley, V.C. (1978). Prevalence of thyroid disorders in Down syndrome. Clinical Genetics, 14, 154–158.PubMedCrossRefGoogle Scholar
  29. Smith, D.W. (1982). Recognizable patterns of human malformations. Philadelphia: W.B. Saunders.Google Scholar
  30. Smith, G.F., Spiker, D., Peterson, C.P., Cicchetti, D. & Justine, P. (1984). Use of megadoses of vitamins with minerals in Down syndrome. Journal of Pediatrics, 105 (2), 228–234.PubMedCrossRefGoogle Scholar
  31. Smith, G.R., & Berg, J.M. (1976). Down’s anomaly, 2d ed. New York: Churchill-Livingstone.Google Scholar
  32. Woillez, M., & Dansant, C. (1960). Les manifestations occulaires dans le mongolisme. Archive of Ophthalmology (Paris), 20, 810–828.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • Don C. Van Dyke
  • David J. Lang
  • John D. Miller
  • Frances Heide
  • Susan van Duyne
  • Hyejung Chang

There are no affiliations available

Personalised recommendations