Abnormality in Immunoregulatory Cells in Human Malignancies

  • Sudhir Gupta
Part of the Advances in Immunity and Cancer Therapy book series (IMMUNITY, volume 2)


Immune regulation may be defined as a process that determines the magnitude, intensity, duration, and tempo of immune responses after the system has been disturbed by an antigen. There are several mechanisms that are involved in immune regulation; their discussion is out of the scope of this chapter, and interested readers are referred to a concise review (1). These immunoregulatory T cell subsets either enhance or suppress the B cell differentiation to plasma cells and T cell proliferation to mitogens, antigens, and alloantigens (2). In normal immune hemostasis, there is a delicate balance between helper and suppressor functions. Immunoregulatory T cell subsets are identified by the presence of receptors for immunoglobulin isotypes (3–5), and the differentiation antigens are defined with monoclonal antibodies (6). A list of these markers is shown in Table 2.1. More recently it has become apparent that even the so-called helper/inducer T cells (OKT4+, T4+, Leu 3+) and suppressor/cytotoxic (OKT8+, T8+, Leu 2+, OKTS+) T cells are not functionally homogeneous. The subject of functional heterogeneity of T4+ and T8+ T cells have recently been reviewed (7). In this chapter, I will discuss primarily the disorders of immunoregulatory T cell subsets and of macrophages in various malignancies, including those stems from normal immunoregulatory T cell subsets themselves.


Chronic Lymphocytic Leukemia Suppressor Cell Mycosis Fungoides Cell Chronic Lymphocytic Leukemia Purify Protein Derivative 
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© Springer-Verlag New York Inc. 1986

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  • Sudhir Gupta

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