Synaptic Transmission

  • R. F. Schmidt
Part of the Springer Study Edition book series (SSE)


The junction of an axonal ending with a nerve cell, a muscle cell, or a glandular cell was first called a synapse by Sherrington (see also Chapter 1, p. 3). At synapses the propagated action potential is transmitted to the next cell. Originally it was wrongly believed that the axon always formed a “gap junction,” that is, was in closest contact with the cell on which it ended so that the propagated impulse could be transmitted without interruption to that cell. However, electrophysiologic and histologic investigations have shown that this form of synapse, which is now called an electrical synapse, is rare. Another type of synapse is far more common, particularly in mammals and thus in man. In this type, the axonal ending when stimulated releases a chemical substance that produces an excitatory or an inhibitory effect at the neighboring cell membrane. This type of synapse is called a chemical synapse. The structure and the function of excitatory and inhibitory chemical synapses will be explained in this chapter.


Synaptic Transmission Synaptic Cleft Presynaptic Terminal Equilibrium Potential Neuromuscular Transmission 
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  1. Burgen A, Kosterlitz HW, Iversen LL (eds) (1980) Neuroactive peptides. The Royal Society, London, pp 1–195Google Scholar
  2. Ceccarelli B, Hurlbut WP (1980) Vesicle hypothesis of the release of quanta of acetylcholine. Physiol Rev 60: 396–441PubMedGoogle Scholar
  3. Cooper JR, Bloom, FE, Roth RH (1978) The biochemical basis of neuropharmacology, 3rd edn. Oxford University Press, New York, pp 1–327Google Scholar
  4. Cottrell GA, Usherwood PNR (eds) (1977) Synapses. Blackie, Glasgow, pp 1–384Google Scholar
  5. DeFeudis FV, Mandel P (eds) (1981) Amino acid neurotransmitter. Raven, New York, pp 1–572Google Scholar
  6. Eccles JC (1964) The physiology of synapses. Springer, Berlin Göttingen Heidelberg New YorkCrossRefGoogle Scholar
  7. Eccles JC (1982) The synapse: from electrical to chemical transmission. Ann Rev. Neurosci 5:325–339PubMedCrossRefGoogle Scholar
  8. Katz B (1966) Nerve, muscle and synapse. McGraw-Hill, New YorkGoogle Scholar
  9. Kravitz EA, Treherne JE (eds) (1980) Neurotransmission, neurotransmitters, and neuromodulators. J Exp Biol 89: 1–286Google Scholar
  10. Loewenstein WR (1981) Junctional intercellular communication: The cell-to-cell membrane channel. Physiol Rev 61: 829–913PubMedGoogle Scholar
  11. Schmidt RF (1971) Presynaptic inhibition in the vertebrate central nervous system. Ergeb Physiol Biol Chem Exp Pharmacol 63: 20–101Google Scholar
  12. Stjärne L, Hedqvist P, Lagercrantz H, Wennmalm Å (eds) (1981) Chemical neurotransmission. Academic Press, New York, pp 1–562Google Scholar
  13. Taxi J (ed) Ontogenesis and functional mechanisms of peripheral synapses. Elsevier, Amsterdam, pp 1–196Google Scholar
  14. The Synapse (1976) Cold Spring Harbor Symp. Quant Biol 40Google Scholar
  15. Tsukahara N (1981) Synaptic plasticity in the mammalian central nervous system. Ann Rev Neurosci 4:351–379PubMedCrossRefGoogle Scholar
  16. Vincent A (1980) Immunology of acetylcholine receptors in relation to myasthenia gravis. Physiol Rev 60: 756–824PubMedGoogle Scholar
  17. Zaimis E (ed) (1976) Neuromuscular junction. Springer, Berlin Heidelberg New York, pp 1–746Google Scholar

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© Springer-Verlag New York, Inc. 1985

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  • R. F. Schmidt

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