Structure of Membranes and Serum Lipoprotein Complexes

  • Milton H. SaierJr.
  • Charles D. Stiles
Part of the Heidelberg Science Library book series (HSL)


In Chapter 2, the principal constituents of biological membranes, lipids and proteins, were examined from a structural standpoint. It was noted that membrane components are, in general, amphipathic; they possess both polar and nonpolar moieties. Thermodynamic considerations lead to the conclusion that such macromolecules in an aqueous environment should associate spontaneously with the formation of structures of maximal stability in which nonpolar elements comprise one phase, polar elements, the other. Since the hydrophobic environment resembles an oil, the structure should be fluid—dynamic—constantly in motion. In this chapter, these predictions are shown to be valid for many biologic membranes. An appreciation of the structural aspects considered below will prove to be one of the keys to the understanding of the intricacies of membrane functions.


Electron Spin Resonance Biological Membrane Peripheral Protein Outer Monolayer Lipoprotein Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Selected References

  1. Assmann, G. and H. B. Brewer, Jr. A molecular model of high density lipoproteins, Proc. Nat. Acad. Sci. US, 77:1534 (1974).CrossRefGoogle Scholar
  2. Edidin, M. Rotational and translational diffusion in membranes, Ann. Rev. Biophys. Bioeng., 3:179 (1974).CrossRefGoogle Scholar
  3. Fox, C. F. and A. D. Keith (eds.). Mennbrane Molecular Biology. Sinauer Associates, Inc., Stamford, Conn. 1972.Google Scholar
  4. Jackson, R. L, J. D. Morrisett, and A. M. Grotto, Jr. “Lipid-protein interactions in human plasma high density lipoproteins,” in Protides of the Biological Fluids, 21st Coll. Brugge (H. Peeters, ed.). Pergamon Press, Oxford, 1973.Google Scholar
  5. Seeman, P. The membrane actions of anesthetics and tranquilizers, Pharmacol. Rev. 24:583 (1972).PubMedGoogle Scholar
  6. Sheetz, M. and S. J. Singer. Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions, Proc. Nat. Acad. Sci. US, 77:4457 (1974).CrossRefGoogle Scholar
  7. Singer, S. J. “Molecular biology of cellular membranes with applications to immunology,” in Advances in Innmunofogy, Vol. 19. Academic Press, Inc., New York, 1974, p. 1.Google Scholar
  8. Singer, S. J. “The molecular organization of membranes,” in Annual Review of Biochennistry, Vol. 43. Annual Reviews, Inc., Palo Alto, Ca. 1974, p. 805.Google Scholar
  9. Singer, S. J. and G. L. Nicolson. The fluid mosaic model of the structure of cell membranes. Science, 175:720 (1972).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1975

Authors and Affiliations

  • Milton H. SaierJr.
    • 1
  • Charles D. Stiles
    • 1
  1. 1.Department of Biology, John Muir CollegeUniversity of California at San DiegoLa JollaUSA

Personalised recommendations