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Wagner Syndrome and Stickler Syndrome

  • Juan Orellana
  • Alan H. Friedman

Abstract

The characteristic features of Wagner syndrome include myopia, an optically empty vitreous, preretinal membranes, perivascular retinal pigment epithelial changes, vascular sheathing, cataracts, and atrophy of the choriocapillaris. The cataracts typically appear as patients approach their 40th birthday. The vitreous bands are broad and insert into the peripheral retina; and there is liquefaction of the vitreous. It is autosomal dominant and usually present bilaturally. It is noteworthy that many physicians consider Wagner syndrome to be a mild form of Stickler syndrome. Wagner syndrome patients, however, do not have systemic changes, whereas Stickler syndrome patients have systemic manifestations. The former patients do not suffer retinal detachments, whereas more than 50% of the Stickler syndrome patients develop a retinal detachment.

Keywords

Hearing Loss Retinal Detachment Color Vision Sensorineural Hearing Loss Cleft Palate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Selected Reading

  1. Alexander RL, Shea M (1965). Wagner’s disease. Arch Ophthalmol 74: 310–318PubMedCrossRefGoogle Scholar
  2. Lisch W (1983). Hereditary vitreoretinal degenerations. Dev Ophthalmol 8: 1–90PubMedGoogle Scholar
  3. Maumenee IH (1979). Vitreoretinal degeneration as a sign of generalized connective tissue diseasses. Am J Ophthalmol 88: 432–449PubMedGoogle Scholar
  4. Maumenee IH, Stoll HU, Mets MB (1982). The Wagner syndrome ver-sus hereditary arthroophthalmopathy. Trans Am Ophthalmol Soc 80: 349–365PubMedGoogle Scholar
  5. Pinkers A, Jansen LMAA (1974). Wagner’s syndrome (degeneratiohyaloideo-retinalis hereditaria). Doc Ophthalmol 37: 245–259CrossRefGoogle Scholar
  6. Stickler GB, Belau PG, Farrell FJ, et al (1965). Hereditary progressive arthro-ophthalmopathy. Mayo Clin Proc 40: 433–455PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Juan Orellana
    • 1
  • Alan H. Friedman
    • 1
  1. 1.Mount Sinai School of MedicineNew YorkUSA

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