Histochemical Studies in Congenital Clubfeet
The etiology of congenital clubfoot is still unknown although this condition has been well described since ancient times. There are many hypotheses about the etiology, such as primary bone dysplasia,14 aberrations of tendon insertions,4,18 abnormalities in tendon sheaths, abnormal intrauterine posture,1 and neuromuscular defects.5,7,10 Histologically, some authors reported no remarkable findings in muscles and nerves,4,5,9 but others recognized remarkable findings using histochemical technique and electron microscopy.5,7,10,19 In an attempt to evaluate the neuromuscular abnormality in congenital clubfeet, we have carried out histochemical studies of muscles in patients with congenital clubfeet.
KeywordsImmobilization Hematoxylin Eosin Kelly Dinucleotide
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