Changes in Topography of Cell Adhesion Molecules during Lymphocyte Migration Across Endothelium

  • Stephen J. Rosenman
  • Patricia A. Hoffman
  • W. Michael Gallatin
Conference paper

Abstract

The widely expressed CD44 single-chain transmembrane glycoprotein has been the object of recent studies in the fields of cell adhesion and lymphocyte activation. This molecule commonly occurs as a 37-kDa polypeptide extensively glycosylated with N- and O-linked oligosaccharides and glycosaminoglycans which migrates in SDS-PAGE as an 80–95-kDa major component of the membranes of most cell types examined (1–3). Higher-molecular-weight forms bearing chondroitin sulfate have been described in lymphoid cells. In other cell types alternately spliced iso-forms possessing an additional extracellular domain exon of 132 or 162 amino acids have been detected (4,5).

Keywords

Migration Carbohydrate Polypeptide Integrin Cane 

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References

  1. 1.
    Rosenman, S., and T. St. John. 1992. CD44. In Guidebook to the Cytos-keletal, Extracellular Matrix, and Adhesion Proteins. T. Kreis and R. Vale, eds., Sambrook and Tooze, Heidelberg, in press.Google Scholar
  2. 2.
    Gallatin, W.M., Rosenman, S.J., Ganji, A., Rees, G., and T. St. John. 1991. Structure function relationships of the CD44 class of glycoproteins. In Cellular and Molecular Mechanisms of Inflammation, Vol. 2: Vascular Adhesion Molecules. C.G. Cochrance and M.A. Gimbrone, Jr., eds., Academic Press, New York, pp.131–150.Google Scholar
  3. 3.
    Rosenman, S.J. and W.M. Gallatin. 1991. Cell surface glycoconjugates in intercellular and cell-substratum interactions. Sem. Canc. Biol. 2:357.Google Scholar
  4. 4.
    Dougherty, G.J., Landsdorp, P.M., Cooper, D.L., and R.K. Humphries. 1991. Molecular cloning of CD44R1 and CD44R2, two novel isoforms of the human CD44 lymphocyte “homing” receptor expressed by hemopoietic cells. J. Exp. Med. 174:1.PubMedCrossRefGoogle Scholar
  5. 5.
    Gunthert, U., Hofmann, M., Rudy, W., Reber, S., Zoller, M., Haussmann, I., Matzku, S., Wenzel, A., Ponta, H., and P. Herrlich. 1991. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 65:13.PubMedCrossRefGoogle Scholar
  6. 6.
    Aruffo, A., Stamenkovic, I., Melnick, M., Underhill, C.B., and B. Seed. 1990. CD44 is the principal cell surface receptor for hyaluronate. Cell 61:1303.PubMedCrossRefGoogle Scholar
  7. 7.
    Gallatin, W.M., Wayner, E.A., Hoffman, P.A., St. John, T., Butcher, E.C., and W.G. Carter. 1989. Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor. Proc. Nat. Acad. Sci. USA 86:4654.PubMedCrossRefGoogle Scholar
  8. 8.
    Gallatin, W.M., T.P. St. John, M. Siegelman, R. Reichert, E.C. Butcher, and I.L. Butcher 1986. Lymphocyte homing receptors. Cell 44:673.PubMedCrossRefGoogle Scholar
  9. 9.
    Jalkanen, S., Bargatze, R.F., de los Toyos, J., and E.C. Butcher. 1987. Lymphocyte recognition of high endothelium: Antibodies to distinct epitopes of an 85–95 kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, muscosal, or synovial endothelial cells. J. Cell Biol. 105:983.PubMedCrossRefGoogle Scholar
  10. 10.
    Goldstein L.A., Zhou D.F.H., Picker L.J., Minty C.N., Bargatze R.F., Ding J.F., and E.C. Butcher. 1989. A human lymphocyte homing receptor, the Hermes antigen, is related to cartilage proteoglycan core and link proteins. Cell 56:1063.PubMedCrossRefGoogle Scholar
  11. 11.
    Idzerda R.L., Carter W.G., Nottenburg C., Wayner E.A., Gallatin W.M., and T. St. John. 1989. Isolation and DNA sequence of a cDNA clone encoding a lymphocyte adhesion receptor for high endothelium. Proc. Nat. Acad. Sci. USA 86:4659.PubMedCrossRefGoogle Scholar
  12. 12.
    Stamenkovic I., Amiot M., Pesando J.M., and B. Seed. 1989. A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family. Cell 56:1057.PubMedCrossRefGoogle Scholar
  13. 13.
    Lasky, L.A., Singer, M.S., Yednock, T.A., Dowbenko, D., Fennie, C., Rodriguez, H., Nguyen, T., Stachel, S., and S.D. Rosen. 1989. Cloning of a lymphocyte homing receptor reveals a lectin domain. Cell 56:1045.PubMedCrossRefGoogle Scholar
  14. 14.
    Siegelman, M., van de Rijn M., and I. Weissman. 1989. Mouse lymph node homing receptor cDNA clone encodes a glycoprotein revealing tandem interaction domains. Science (Wash. DC) 243:1165.CrossRefGoogle Scholar
  15. 15.
    Tedder, T.F., Isaac, C.M., Ernst, T.J., Demetri, G.D., Adler, D.A., and C.M. Disteche. 1989. Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins. J. Exp. Med. 170:123.PubMedCrossRefGoogle Scholar
  16. 16.
    Bowen, B., Nguyen T., and L. Lasky. 1989. Characterization of a human homologue of the murine peripheral lymph node homing receptor. J. Cell Biol. 109:421.PubMedCrossRefGoogle Scholar
  17. 17.
    Camerini D., James S.P., Stamenkovic I., and B. Seed. 1989. Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor. Nature 342:78.PubMedCrossRefGoogle Scholar
  18. 18.
    Brandley B.K., Swiedler S.J., and P.W. Robbins. 1990. Carbohydrate ligands of the LEC cell adhesion molecules. Cell 63:861.PubMedCrossRefGoogle Scholar
  19. 19.
    St. John T., Meyer J., Idzerda R., and W.M. Gallatin. 1990. Expression of CD44 confers a new adhesive phenotype on transfected cells. Cell 60:45.CrossRefGoogle Scholar
  20. 20.
    Albelda, S.M., and CA. Buck. 1990. Integrins and other cell adhesion molecules. FASEB J. 4:2868.PubMedGoogle Scholar
  21. 21.
    Hemler, M.E. 1990. VLA proteins in the integrin family: Structures, functions, and their role on leukocytes. Ann. Rev. Immunol. 8:365.CrossRefGoogle Scholar
  22. 22.
    Imai, Y., Singer, M.S., Fennie, C., Lasky, L.A., and S.D. Rosen. 1991. Identification of a carbohydrate-based endothelial ligand for a lymphocyte homing receptor. J. Cell Biol. 113:1213.PubMedCrossRefGoogle Scholar
  23. 23.
    Selvaraj, P.M., Plunkett, M.L., Dustin, M., Sanders, M.E., Shaw, S., and T.A. Springer. 1987. The T lymphocyte glycoprotein CD2 (LFA-2/T11/E-rosette receptor) binds the cell surface ligand LFA-3. Nature 326:400.PubMedCrossRefGoogle Scholar
  24. 24.
    Springer, T.A. 1990. Adhesion receptors of the immune system. Nature 346:425.PubMedCrossRefGoogle Scholar
  25. 25.
    Rosenman S.J., Ganji A.A., Tedder T.F., and W.M. Gallatin. 1992. Syn-capping of human T lymphocyte adhesion/activation molecules and their redistribution during interaction with endothelial cells. J. Leuk. Biol, in press.Google Scholar
  26. 26.
    Bourguignon, L.Y.W., and G.J. Bourguignon. 1984. Capping and the cyto-skeleton. Int. Rev. Cytol. 87:195.PubMedCrossRefGoogle Scholar
  27. 27.
    Kupfer, A. and S.J. Singer. 1989. Cell biology of cytotoxic and helper T cell functions: Immunofluorescence microscopic studies of single cells and cell couples. Ann. Rev. Immunol. 7:309.CrossRefGoogle Scholar
  28. 28.
    Masinovsky, B., Urdal, D., and W.M. Gallatin. 1990. IL-4 acts synergistically with IL-1b to promote lymphocyte adhesion to microvascular endothelium by induction of vascular cell adhesion molecule-1. J. Immunol. 145:2886.PubMedGoogle Scholar
  29. 29.
    Pober, J.S. and R.S. Cotran. 1990. The role of endothelial cells in inflammation. Transplantation 50:537.PubMedCrossRefGoogle Scholar
  30. 30.
    Spertini, O., Luscinskas, F.W., Kansas, G.S., Munro, J.M., Griffin, J.D., Gimbrone, M.A., Jr., and T.F. Tedder. 1991. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J. Immunol. 147:2565.PubMedGoogle Scholar
  31. 31.
    Kavanaugh, A.F., Lightfoot, E., Lipsky, P.E., and N. Oppenheimer-Marks. 1991. Role of CD11/CD18 in adhesion and transendothelial migration of T cells: Analysis utilizing CD18-deficient T cell clones. J. Immunol. 146:4149.PubMedGoogle Scholar
  32. 32.
    Oppenheimer-Marks, N., Davis, L.S., and Lipsky, P.E. 1990. Human T lymphocyte adhesion to endothelial cells and transendothelial migration: Alteration of receptor use relates to the activation status of both the T cell and the endothelial cell. J. Immunol. 145:140.PubMedGoogle Scholar
  33. 33.
    Shimizu, Y., Newman, W., Gopal, T.V., Horgan, K.J., Graber, N., Beall, L.D., van Seventer, G.A., and S. Shaw. 1991. Four molecular pathways of T cell adhesion to endothelial cells: Roles of LFA-1, VCAM-1, and ELAM-1 and changes in pathway hierarchy under different activation conditions. J. Cell Biol 113:1203.PubMedCrossRefGoogle Scholar
  34. 34.
    Denning, S.M., Le, P.T., Singer, K.H., and B.F. Haynes. 1990. Antibodies against the CD44 p80, lymphocyte homing receptor molecular augment human peripheral blood T cell activation. J. Immunol. 144:7.PubMedGoogle Scholar
  35. 35.
    Huet, S., Groux, H., Caillou, B., Valentin, H., Prieur, A., and A. Bernard. 1989. CD44 contributes to T cell activation. J. Immunol. 143:798.PubMedGoogle Scholar
  36. 36.
    Shimizu, Y., Van Seventer, G.A., Siraganian, R., Wahl, L., and S. Shaw. 1989. Dual role of the CD44 molecule in T cell adhesion and activation. J. Immunol. 143:2457.PubMedGoogle Scholar
  37. 37.
    Bierer, B.E., and S.J. Burakoff. 1991. T cell receptors: Adhesion and signaling. Adv. Cancer Res. 56:49.PubMedCrossRefGoogle Scholar
  38. 38.
    Pilarski, L.M., Turley, E.A., Shaw, A.R.E., Gallatin, W.M., Laderoute, M.P., Gillitzer, R., Beckman, I.G.R., and H. Zola. 1991. FMC46, a cell protrusion-associated leukocyte adhesion molecule-1 epitope on human lymphocytes and thymocytes. J. Immunol. 147:136.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1993

Authors and Affiliations

  • Stephen J. Rosenman
  • Patricia A. Hoffman
  • W. Michael Gallatin

There are no affiliations available

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