Abstract
Leukocyte entry into tissues is the hallmark of all types of acute and chronic inflammatory events. Both inflammation and leukocyte specificity are exhibited in this process. In most situations, cells such as monocytes, neutrophils, and eosinophils do not constitutively traffic through tissues in significant numbers. However, their numbers in tissues can be dramatically increased after certain inflammatory insults. Leukocyte specificity is illustrated by the predominance of neutrophils in sites of early acute inflammation, mononuclear cells in sites of chronic inflammation, and eosinophils in sites of inflammation associated with allergies or parasitic infection.
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References
Jutila, M.A., L. Rott, E.L. Berg, and E.G. Butcher. 1989. Function and regulation of the neutrophil Mel-14 antigen in vivo: Comparison with LFA-1 and Mac-1. J. Immunol. 143:3318.
Kishimoto, T.K., M.A. Jutila, E.L. Berg, and E.G. Butcher. 1989. Neutrophil Mac-1 and Mel-14 adhesion proteins inversely regulated by chemotac-tic factors. Science (Wash. D.C.) 245:1238.
Jung, T.M. and M.O. Dailey. 1990. Rapid modulation of homing receptors (gp90MEL-14) induced by activators of protein kinase C.: Receptor signalling due to accelerated proteolytic cleavage at the cell surface. J. Immunol. 144:3130.
Jutila, M.A., T.K. Kishimoto, and M. Finken. 1990. Low dose Chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: Effects on Mac-1 and Mel-14 adhesion protein expression and function. Cell. Immunol. 132:201.
Lewinsohn, D.M., R.F. Bargatze, and E.G. Butcher. 1987. Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes and other leukocytes. J. Immunol. 138:4313.
Stamper, H.B. and J.J. Woodruff. 1976. Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high endothelial venules. J. Exp. Med. 144:828.
Kishimoto, T.K., M.A. Jutila, and E.G. Butcher. 1990. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc. Natl. Acad. Sci. USA 87:2244.
Hallman, R., M.A. Jutila, C.W. Smith, D.C. Anderson, T.K. Kishimoto, and E.G. Butcher. 1990. CD18-independent adhesion of human neutrophils to endothelium involves a cell adhesion molecule related to the lymph node homing receptors. Biochem. Biophy. Res. Commun. 174:236.
Abbassi, O., T.K. Kishimoto, C.L. Lane, L.V. McIntire, and C.W. Smith. 1991. Endothelial-leukocyte adhesion molecule-1 supports neutrophil rolling in vitro under conditions of flow. Submitted.
Smith, C.W., T.K. Kishimoto, O. Abbass, B. Hughes, R. Rothlein, L.V. McIntire, E.C. Butcher, and D.C. Anderson. 1991. Chemotactic factors regulate lectin adhesion molecule 1 (LECAM-l)-dependent neutrophil adhesion to cytokine-stimulated endothelial cells in vitro. J. Clin. Invest. 87:609.
Kishimoto, T.K., R.A. Warnock, M.A. Jutila, E.C. Butcher, D.C. Anderson, and C.W. Smith. 1990. Antibodies against human neutrophil LECAM-1 (DREG56/LAM-1/Leu-8 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78:805.
Picker, L.J., R.A. Warnock, A.R. Burns, C.M. Doerschuk, E.L. Berg and E.C. Butcher. 1991. The neutrophil selectin LECAM-1 presents carbohydrate ligands to the vascular selectin ELAM-1 and GMP-140. Cell 66:921.
Watson, S.R., C. Fennie, and L.A. Lasky. 1991. Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimaera. Nature (London) 349:164.
Ley, K., P. Gaehtgens, C. Fennie, M.S. Singer, L.A. Lasky, and S.D. Rosen. 1991. Lectin-like adhesion molecule-1 mediates leucocyte rolling in mesenteric venules in vivo. Blood 77:2553.
von Andrian, U.H., J.D. Chambers, L. McEvoy, R.F. Bargatze, K.E. Arfors, and E.C. Butcher. 1991. Two step model of leukocyte-endothelial cell interaction in inflammation: Distinct roles for LECAM-1 and leukocyte beta-2 integrins in vivo. Proc. Natl Acad. Sci. USA 88:7538.
Kehrli, M.E., F.C. Schmalstieg, D.C. Anderson, M.J. Van Der Maaten, B.J. Hughes, M.R. Ackermann, C.L. Wilhelmsen, G.B. Brown, M.G. Stevens, and C.A. Whetstone. 1990. Molecular definition of the bovine granulocyto-pathy syndrome: Identification of deficiency of the Mac-1 (CD11b/CD18) glycoprotein. Am.J. Vet. Res. 51:1826.
Hein, W.R. and C.R. Mackay. 1991. Prominence of gamma/delta T cells in the ruminant immune system. Immunol. T. 12:30.
Jutila, M.A. and K.L. Banks. 1988. Increased synovial fluid macrophage division in Caprine Arthritis-Encephalitis virus infection. J. Infect. Disease 157:1193.
Walcheck, B., M. White, S. Kurk, T.K. Kishimoto, and M.A. Jutila. 1992. Characterization of the bovine peripheral lymph node homing receptor: a lectin cell adhesion molecule (LECAM). Eur. J. Immunol. 22:469.
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Walcheck, B., Jutila, M.A. (1993). The Contribution of L-Selectin to Leukocyte Trafficking In Vivo . In: Lipsky, P.E., Rothlein, R., Kishimoto, T.K., Faanes, R.B., Smith, C.W. (eds) Structure, Function, and Regulation of Molecules Involved in Leukocyte Adhesion. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9266-8_14
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DOI: https://doi.org/10.1007/978-1-4613-9266-8_14
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