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Genetic Causes of Spontaneous Abortion

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The High-Risk Fetus

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Abstract

Pregnancy loss is a very frequent phenomenon. At least 30% of pregnancies recognized on the basis of human chorionic gonadotropin (hCG) assays are lost, often prior to clinical recognition of pregnancy. Genetic factors are responsible for most losses in clinically recognized pregnancies, and probably also for most losses before clinical recognition. In this chapter we consider first the frequency and timing of pregnancy loss and then enumerate known genetic causes. Specific consideration of the role of non-genetic factors in pregnancy loss is discussed in Chapter 6.

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Authors
  1. Joe Leigh Simpson
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Editors and Affiliations

  1. Maternal-Fetal Medicine Section, Pritzker School of Medicine, University of Chicago, 60637, Chicago, IL, USA

    Chin-Chu Lin M.D. (Professor of Obstetrics and Gynecology, Director, Obstetrics High Risk Clinic) & Marion S. Verp M.D. (Associate Professor of Clinical Obstetrics and Gynecology, Director, Medical Genetic Services) (Professor of Obstetrics and Gynecology, Director, Obstetrics High Risk Clinic) &  (Associate Professor of Clinical Obstetrics and Gynecology, Director, Medical Genetic Services)

  2. Northwestern Memorial Hospital, Prentice Women’s Hospital, 60611, Chicago, IL, USA

    Rudy E. Sabbagha M.D. (Professor of Obstetrics and Gynecology, Northwestern University, Director, Diagnostic Ultrasound Center) (Professor of Obstetrics and Gynecology, Northwestern University, Director, Diagnostic Ultrasound Center)

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© 1993 Springer-Verlag New York Inc.

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Simpson, J.L. (1993). Genetic Causes of Spontaneous Abortion. In: Lin, CC., Verp, M.S., Sabbagha, R.E. (eds) The High-Risk Fetus. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9240-8_5

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  • DOI: https://doi.org/10.1007/978-1-4613-9240-8_5

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-9242-2

  • Online ISBN: 978-1-4613-9240-8

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