Abstract
Mitogenesis, or an increase in cell replication, has been proposed as a major rate-limiting factor in carcinogenesis (1). With respect to breast cancer, excess estrogen has been proposed to lead to increased proliferation of mammary epithelium (2). We have asked the question of whether a hormonally induced alteration(s) in cell proliferation is an integral feature of the multiple rate-limiting events (3) that underlie the chemically induced transformation of normal mammary epithelial cells to their malignant counterparts. Recent observations suggest that the hormonal environment at the time of administration of the direct acting carcinogen methylnitrosourea (MNU) significantly alters the early development and subsequent biology of mammary tumors in the rat without significantly altering the hormonal environment itself (4,5).
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© 1992 Springer-Verlag New York, Inc.
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Beattie, C.W., Anderson, C.H. (1992). Estrous Cycle Modification of Rat Mammary Carcinoma Induction. In: Li, J.J., Nandi, S., Li, S.A. (eds) Hormonal Carcinogenesis. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-9208-8_9
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DOI: https://doi.org/10.1007/978-1-4613-9208-8_9
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