Hormonal Regulation of Plasminogen Activation in the Human Endometrium
Plasminogen activation is a crucial step in proteolytic events that result in the degradation of extracellular matrix proteins during processes involving tissue proliferation (i.e., tumor growth and metastasis). Hormonal regulation of tissue proliferation can be studied in the endometrium where proliferation is stimulated by estradiol and arrested by progesterone. Plasminogen activator activity of the endometrium increased in the proliferative phase under influence of estradiol and decreased after ovulation in response to progesterone. We found that the decreased plasminogen activator activity was the result of decreased production of urokinase plasminogen activator and increased production of plasminogen activator inhibitor 1. These changes combined to shift the activator/inhibitor balance to a reduced activator activity, which is relevant to the reduced need for plasminogen activation once proliferation is arrested.
KeywordsMigration Sarcoma Progesterone Estradiol Prolactin
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