Hormonal Regulation of Plasminogen Activation in the Human Endometrium

  • Bertil G. Casslén
Conference paper


Plasminogen activation is a crucial step in proteolytic events that result in the degradation of extracellular matrix proteins during processes involving tissue proliferation (i.e., tumor growth and metastasis). Hormonal regulation of tissue proliferation can be studied in the endometrium where proliferation is stimulated by estradiol and arrested by progesterone. Plasminogen activator activity of the endometrium increased in the proliferative phase under influence of estradiol and decreased after ovulation in response to progesterone. We found that the decreased plasminogen activator activity was the result of decreased production of urokinase plasminogen activator and increased production of plasminogen activator inhibitor 1. These changes combined to shift the activator/inhibitor balance to a reduced activator activity, which is relevant to the reduced need for plasminogen activation once proliferation is arrested.


Plasminogen Activator Hormonal Regulation Proliferative Phase Endometrial Tissue Plasminogen Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Stephens RW, Pöllânen J, Tapiovaara H, Leung K-C, Sim P-S, Salonen E-M, Rönne E, Behrendt N, Danö K, Vaheri A (1989) Activation of prourokinase and plasminogen on human sarcoma cells: A proteolytic system with surface-bound reactants. Cell Biol 108: 1987–1995.CrossRefGoogle Scholar
  2. 2.
    Grimaldi G, Di Fiore P, Locatelli EK, Falco J, Blasi F (1986) Modulation of urokinase plasminogen activator gene expression during the transition from quiescent to proliferative state in normal mouse cells. The EMBO Journal 5: 855–861.PubMedGoogle Scholar
  3. 3.
    Ossowski L (1988) In vivo invasions of modified chorioallantoic membrane by tumor cells: the role of cell surfacebound urokinase. J Cell Biol 107:2437–2445.PubMedCrossRefGoogle Scholar
  4. 4.
    Baker MS, Bleakley P, Woodrow GC, Doe WF (1990) Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation. Cancer Res 50: 4676–4684.PubMedGoogle Scholar
  5. 5.
    Casslén B, Astedt B (1983) Occurrence of both urokinase and tissue plasminogen activator in the human endometrium. Contraception 28: 553–564.PubMedCrossRefGoogle Scholar
  6. 6.
    Casslén B, Astedt B (1981) Fibrinolytic activity of human uterine fluid. Acta Obstet Gynecol Scand 60: 55–58.PubMedCrossRefGoogle Scholar
  7. 7.
    Casslén B, Ohlsson K (1981) Cyclic variation of plasminogen activation in human uterine fluid and influence of an intrauterine device. Acta Obstet Gynecol Scand 60: 97–101.PubMedGoogle Scholar
  8. 8.
    Casslén B, Thorell J, Astedt B (1981) Effect of IUD on urokinase-like immunoreactivity and plasminogen activators in human uterine fluid. Contraception 23: 435–445.PubMedCrossRefGoogle Scholar
  9. 9.
    Casslén B, Andersson A, Nilsson IM, Astedt B (1986) Hormonal regulation of the release of plasminogen activators and of a specific activator inhibitor from endometrial tissue in culture. Proc Soc Exptl Biol Med 182: 419–424.Google Scholar
  10. 10.
    Casslén B, Siler-Khodr TM, Harper MJK (1990) Progesterone regulation of prolactin release from human endometrial stromal cells in culture: Potential bioassay for progestational activity. Acta Endocrinol 122: 137–44.PubMedGoogle Scholar
  11. 11.
    Astedt B, Holmberg L, Lecander I, Thorell J (1981) Radioimmunoassay of urokinase for quantification of plasminogen activators released in ovarian tumour cultures. Europ J Cancer 17: 239–44.CrossRefGoogle Scholar
  12. 12.
    Cunha GR (1976) Stromal induction and specification of morphogenesis and cytodifferentiation of the epithelia of the m» llerian ducts and urogenital sinus during development of the uterus and vagina in mice. J Exp Zool 196: 361–370.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Bertil G. Casslén

There are no affiliations available

Personalised recommendations