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The Dynamics of the Organism: Can Mind and Body Be Integrated?

  • Herbert Weiner

Abstract

The mind—brain—body problem in medicine re-mains unsolved.1 Serious attempts to resolve this central philosophical issue have been made only by those physicians who ascribe to the principles of psychosomatic medicine.2–5 As soon as the question How does an emotion “cause” material or physiological changes in the body? is posed, however, an impasse is reached. (The answer is: It does not! They may or may not covary.) The traditional (Cartesian) manner in which the problem is stated is not solvable as long as the brain and body are defined as, and made up of, material units extended in space, but mental phenomena are immaterial and not extended.

Keywords

Anorexia Nervosa Turner Syndrome Central Pattern Generator Psychosomatic Medicine Messenger Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Weiner H. Die Geschichte der Psychosomatischen Medizin und das Leib-Seele-Problem in der Medizin. Psychother Psychosom Med Psychol. 1986;36:361–391.PubMedGoogle Scholar
  2. 2.
    Engel GL. The need for a new medical model: a challenge for biomedicine. Science. 1977;196:129–136.PubMedCrossRefGoogle Scholar
  3. 3.
    Weiner H. Psychobiology and Human Disease. New York: Elsevier; 1977.Google Scholar
  4. 4.
    Lipowski ZJ. What does the word “psychosomatic” really mean? A historical and semantic inquiry. Psychosom Med. 1984;46:153–171.PubMedGoogle Scholar
  5. 5.
    Blois MS. Medicine and the nature of vertical reasoning. N Engl J Med. 1988;318:847–851.PubMedCrossRefGoogle Scholar
  6. 6.
    Rapp PE, Mees AI, Sparrow CT. Frequency encoded biochemical regulation is more accurate than amplitude dependent control. J Theor Biol. 1981;90:531–544.PubMedCrossRefGoogle Scholar
  7. 7.
    Rapp PE. Bifurcation theory, control theory and metabolic regulation. In: Linkens D, ed. Biological Systems, Modelling and Control. New York: Peregrinus; 1979:1–83.Google Scholar
  8. 8.
    Garfinkel A. A mathematics for physiology. Am J Physiol. 1983;245:R455–R466.PubMedGoogle Scholar
  9. 9.
    Holden AV. What makes them tick? Book review: From Clocks to Chaos. The Rhythms of Life by Leon Glass and Michael Mackey. Nature. 1988;336:119.CrossRefGoogle Scholar
  10. 10.
    Moore-Ede MC, Sulzman FM, Fuller CA. The Clocks That Time Us. Cambridge, Mass: Harvard University Press; 1982:294–343.Google Scholar
  11. 11.
    Glass L, Mackey MC. From Clocks to Chaos. The Rhythms of Life. Princeton, NJ: Princeton University Press; 1988.Google Scholar
  12. 12.
    Hodgkin AL, Huxley AF. A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol (Lond). 1952;117:500–544.Google Scholar
  13. 13.
    Llinás RR. The intrinsic electrophysiological properties of mammalian neurons: Insights into central nervous system function. Science. 1988;242:1654–1664.PubMedCrossRefGoogle Scholar
  14. 14.
    McLennan AD, Grillner S. Activation of “fictive” swimming by microstimulation of brain stem locomotor regions in an in vivo preparation of lamprey central nervous system. Brain Res. 1984;300:357–361.CrossRefGoogle Scholar
  15. 15.
    Mackey MC, Milton JG. Dynamical diseases. Ann NY Acad Sci. 1987;504:16–32.PubMedCrossRefGoogle Scholar
  16. 16.
    Reisine DT. Molecular mechanisms controlling ACTH release. In: Weiner H, Hellhammer D, Florin I, Murison RC, eds. Neuronal Control of Bodily Function: Basic and Clinical Aspects. Frontiers of Stress Research. Toronto: Hans Huber; 1989;4:240–249.Google Scholar
  17. 17.
    Ehlers CL, Frank E, Kupfer DJ. Social Zeitgebers and biological rhythms. A unified approach to understanding the etiology of depression. Arch Gen Psychiatry. 1988;45:948–952.PubMedGoogle Scholar
  18. 18.
    Wehr TA, Goodwin FK, eds. Circadian Rhythms in Psychiatry. Pacific Grove, Calif: Boxwood Press; 1983.Google Scholar
  19. 19.
    Melnechuk T. Cell Receptor Disorders. LaJolla, Calif: Western Behavioral Sciences Institute; 1978.Google Scholar
  20. 20.
    Rubenstein E. Diseases caused by impaired communication among cells. Sci Am. 1980; 242:102–121.PubMedCrossRefGoogle Scholar
  21. 21.
    Glass L, Mackey MC. Pathological conditions resulting from instabilities in physiological control systems. Ann NY Acad Sci. 1979;316:214–235.PubMedCrossRefGoogle Scholar
  22. 22.
    Whitehead WE, Schuster MM. Gastrointestinal Disorders: Behavioral and Physiological Basis for Treatment. Orlando, Fla: Academic Press; 1985:53–65.Google Scholar
  23. 23.
    Chey WY, Yon CH, Lee KY, Menguy R. Gastric dysrhythmia: Clinical aspects. In: Chey WY, ed. Functional Disorders of the Gastrointestinal Tract. New York: Raven Press; 1983:175–181.Google Scholar
  24. 24.
    Whitehead WE, Engel BT, Schuster MM. Irritable bowel syndrome: physiological and psychological differences between diarrhea-predominant and constipation-predominant patients. Dig Dis Sci. 1980;25:404–413.PubMedCrossRefGoogle Scholar
  25. 25.
    Snape WJ, Cohen S. How colonic motility differs in normal subjects and patients with IBS. Pract Gastroenterol. 1979;3:21–25.Google Scholar
  26. 26.
    Moldofsky H. Stress, disordered sleep and fibrositis syndrome. In: Weiner H, Hellhammer D, Florin I, Murison RC, eds. Neuronal Control of Bodily Function: Basic and Clinical Aspects: Frontiers of Stress Research. Toronto: Hans Huber; 1989;4:355–365.Google Scholar
  27. 27.
    Magarian GJ. Hyperventilation syndromes: infrequently recognized common expressions of anxiety and stress. Medicine. 1982;61:219–239.PubMedCrossRefGoogle Scholar
  28. 28.
    Farber E. The multistep nature of cancer development. Cancer Res. 1984;44:4217–4223.PubMedGoogle Scholar
  29. 29.
    Newsom-Davis J. Autoimmunity in neuromuscular disease. Ann NY Acad Sci. 1988;540: 25–38.PubMedCrossRefGoogle Scholar
  30. 30.
    Molnar GD, Taylor WF, Langworthy AL. Plasma immunoreactive insulin patterns in insulintreated diabetics. Mayo Clin Proc. 1972;47:709–729.PubMedGoogle Scholar
  31. 31.
    Rook AH, Masur H, Lane HC, et al. Interleukin-2 enhances the depressed natural killer and CMV-specific cytotoxic activation of lymphocytes from patients with the acquired immunodeficiency syndrome. J Clin Invest. 1983;72:398–403.PubMedCrossRefGoogle Scholar
  32. 32.
    Murray HW, Rubin BY, Masur H, Roberts RB. Impaired production of lymphokines and immune (gamma) interferon in the acquired immunodeficiency syndrome. N Engl J Med. 1984;310:883–889.PubMedCrossRefGoogle Scholar
  33. 33.
    Prince HE, Kermani-Arab V, Fahey JL. Depressed interleukin-2 receptor expression in acquired immune deficiency and lymphadenopathy syndrome. J Immunol. 1984;133:1313–1317.PubMedGoogle Scholar
  34. 34.
    Smith P, Ohura K, Masur H, Lane HC, Fauci AS, Wahl SM. Monocyte function in the ac-quired immune deficiency syndrome. Defective Chemotaxis. J Clin Invest. 1984;74:2121–2128.PubMedCrossRefGoogle Scholar
  35. 35.
    Boyar RM, Ramsay J, Chipman J, Fevre M, Madden J, Marks J. Regulation of gonadotropin secretion in Turner’s syndrome. N Engl J Med. 1978;298:1328–1331.PubMedCrossRefGoogle Scholar
  36. 36.
    Boyar RM, Katz JL, Finkelstein JW, et al. Anorexia nervosa: immaturity of the 24-hour luteinizing hormone secretory pattern. N Engl J Med. 1974;291:861–865.PubMedCrossRefGoogle Scholar
  37. 37.
    Weiner H. Women’s disorders. Psychoendocrinology of anorexia nervosa. Psychiatr Clin North Am. 1989;12(special issue): 187–206.PubMedGoogle Scholar
  38. 38.
    Zumoff B, Freeman R, Coupey S, Saenger P, Markowitz M, Kream J. A chronobiological abnormality in luteinizing hormone secretion in teenage girls with the polycystic ovary syndrome. N Engl J Med. 1983;309:1206–1209.PubMedCrossRefGoogle Scholar
  39. 39.
    Fehm HL, Voigt KH, Kummer GW, Pfeiffer EF. Positive rate-sensitive corticosteroid feedback mechanism of ACTH secretion in Cushing’s disease. J Clin Invest. 1979;64:102–108.PubMedCrossRefGoogle Scholar
  40. 40.
    Grossman MI. Abnormalities of acid secretion in patients with duodenal ulcer. Gastroenterology. 1978;75:524–526.PubMedGoogle Scholar
  41. 41.
    Prigogine I. From Being to Becoming. Time and Complexity in the Physical Sciences. San Francisco: WH Freeman; 1980.Google Scholar
  42. 42.
    Weinberg S. Newtonianism, reductionism and the art of congressional testimony. Nature (Lond). 1987;330:433–437.CrossRefGoogle Scholar
  43. 43.
    Winfree AT. When Time Breaks Down. Princeton, NJ: Princeton University Press; 1987.Google Scholar

Copyright information

© Springer-Verlag New York, Inc. 1992

Authors and Affiliations

  • Herbert Weiner

There are no affiliations available

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