Biosynthesis and Processing of the Cytoadhesins, GPIIb/IIIa and Vitronectin Receptor

  • A. Troesch
  • A. Duperray
  • R. Berthier
  • G. Marguerie
Conference paper
Part of the Experimental Hematology Today—1989 book series (HEMATOLOGY, volume 1989)


Integrins are heterodimers comprised of non covalently associated α and β subunits (1, 2). This family has been divided into four groups of adhesion receptors, according to their β subunit. Each group is composed of glycoproteins sharing the same β subunit and different α subunits. This includes the VLA family (3), the leukocyte adhesion proteins LFA-1, Mac-1 and p 150,95 (4), the cytoadhesin family (5), and the newly identified epithelial integrin (6). The platelet GPIIb/IIIa and the vitronectin receptor (VNR) belong to the cytoadhesin family (5) and share the same β subunit, i.e. GPIIIa or VNRβ (7), according to its primary sequence (8–10) and distinct a subunits, i.e. GPIIb or VNRα (11–13).


Proteolytic Cleavage Carbohydrate Chain Oligosaccharide Chain Early Assembly Vitronectin Receptor 
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Copyright information

© Springer-Verlag New York Inc. 1990

Authors and Affiliations

  • A. Troesch
  • A. Duperray
  • R. Berthier
  • G. Marguerie

There are no affiliations available

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