Abstract
The approximately 100 serotypes of human rhinovirus (HRV) [1], the most commonly isolated virus from those suffering from an upper respiratory infection (common cold), represent a formidable therapeutic challenge [2]. A number of structurally unrelated compounds (Figure 39.1) have been shown to inhibit HRV uncoating (i.e., the release of viral RNA into the cytosol) as a result of site-specific binding to virions. Recently, X-ray crystallographic analysis of disoxaril, [5-[7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]heptyl]-3methylisoxazole]=HRV(type 14) complexes has identified the specific binding site in the viral capsid [3,4]. In this chapter the molecular details and biological consequences of the binding of several antiviral compounds to HRV-14 are discussed.
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Dutko, F.J., McKinlay, M.A., Rossmann, M.G. (1989). Antiviral Compounds Bind to a Specific Site Within Human Rhinovirus. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8890-6_39
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DOI: https://doi.org/10.1007/978-1-4613-8890-6_39
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