Abstract
Human immunodeficiency viruses (HIV-1 and HIV-2) and the simian immunodeficiency viruses (SIVs) are members of the lentivirus subfamily of retroviruses. HIV-1 and HIV-2 were isolated from humans with AIDS, and SIVs, a related group, were isolated from various species of African and Asian monkeys (Table 26.1). These three lentiviruses have been used for three different animals models of AIDS. Each model has different applications; their use and current status are the subject of this review. The three animal models are (1) infection of chimpanzees (Pan troglodytes) with HIV-1 [1], (2) infection of rhesus macaques (mac) (Macaca mulatta) with HIV-2 [2], and (3) infection of various macaque species (monkeys belonging to the genus Macaca) with one of the various SIVs (Table 26.1) found in Asian macaques, West African sooty mangabeys (sm), and East African green monkeys (agm) [3–9].
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Alter HJ, Eichberg JW, Masur H, Saxinger WC, Gallo RC, Macher AM, Lane HC, Fauci AS (1984) Transmission of HTLV-III infection from human plasma to chimpanzees: An animal model for AIDS. Science 226: 549–552
Fultz PN, Switzer W, McClure HM, Anderson D, Montagnier L (1988) Simian models for AIDS: SIV/SMM and HIV-2 infection of macaques. In Ginsburg H, Brown F, Lerner RA, Chanock RM (eds) Vaccines 88. CSHL Publisher, CSH New York, pp 167–170
Daniel MD, Letvin NL, King NW, Kannagi M, Sehgal PK, Hunt RD, Kanki PJ, Essex M, Desrosiers RC (1985) Isolation of T-cell tropic HTLV-III-like retrovirus from macaques. Science 228: 1201
Benveniste RE, Morton WR, Clark EA, Tsai C-C, Ochs HD, Ward JM, Kuller L, Knott WB, Hill RW, Gale MJ, Thouless ME (1988) Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. J Virol 62: 2091–2101
Lowenstine L, Lerche N, Jennings M, Marx P, Gardner M, Pedersen N (1987) An epizootic of simian AIDS caused by SIV in captive macaques in the 1970’s. In Girard M, deThe G, Vallette L (eds) Retroviruses of Human AIDS and Related Animal Viruses Pasteur Vaccine, Lyon. pp 174–176
Murphey-Corb M, Martin LN, Rangan SRS, Baskin GB, Gormus BJ, Wolf RH, Andes WA, West M, Montelaro RC (1986) Isolation of an HTLV-Ill related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Nature 321: 435–437
Fultz PN, McClure HM, Anderson DC, Swenson RB, Anand R, Srinivasan A (1986) Isolation of a T-lymphotropic retrovirus from naturally infected sooty mangabey monkeys (Cercoce bus atys). Proc Natl Acad Sci USA 83: 5286–5290
Lowenstine LJ, Pedersen NC, Higgins J, Pallis KC, Uyeda A, Marx P, Lerche NW, Munn RJ, Gardner MB (1986) Seroepidemiologic survey of captive Old World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (cercocebus atys). Int J Cancer 38: 563–575
Fukasawa M, Miura T, Hasegawa A, Morikawa S, Tsujimoto H, Miki K, Kitamura T, Hayami M (1988) Sequence of simian immunodeficiency virus from African green monkey, a new member of the HIV—SIV group. Nature 333: 457–461
Morrow WJW, Wharton M, Lau D, Levy JA (1987) Small animals species are not susceptible to HIV infection. J Gen Virol 68: 2253–2257
Fultz P, McClure HM, Daugharty H, Brodie A, McGrath CR, Swenson B, Francis DP (1986) Vaginal transmission of human immunodeficiency virus ( HIV) to a chimpanzee. J Infect Dis 5: 896–900
Berman PW, Groopman JE, Gregory T, Clapham PR, Weiss RA, Ferriani R, Riddle L, Shimasaki C, Lucas C, Lasky LA, Eichberg JW (1988) Human immunodeficiency virus type 1 challenge of chimpanzees immunized with recombinant envelope glycoprotein gp120. Proc Natl Acad Sci USA 85: 5200–5204
Letvin NL, Daniel MD, Sehgal PK, Desrosiers RC, Hunt RD, Waldron LM, MacKoy JJ, Schmidt DK, Chalifoux LV, King NW (1985) Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovirus STLV-III. Science 230: 71–73
Kestler III HW, Yen L, Naidu YM, Butler CV, Ochs MF, Jaenel G, King NW, Daniel MD, Desrosiers RC (1988) Comparison of simian immunodeficiency virus isolates. Nature 331: 619–620
Hirsch V, Riedel N, Mullins JI (1987) The genome organization of STLV-3 is similar to that of the AIDS virus except for a truncated transmembrane protein. Cell 49: 307–319
Chakrabarti L, Guyader M, Alizon M, Daniel MD, Desrosiers RC, Tiollais P, Sonigo P (1987) Sequence of simian immunodeficiency virus from macaque and its relationship to other human and simian retroviruses. Nature 328: 543–547
Franchini G, Gurgo C, Guo HG, Gallo RC, Collalti E, Fargnoli KA, Hall LF, Wong-Staal F, Reitz Jr MS (1987) Sequence of simian immunodeficiency virus and its relationship to the human immunodeficiency viruses. Nature 328: 539–543
Daniel MD, Letvin NL, Sehgal PK, Hunsmann G, Schmidt DK, King NW, Desrosiers RC (1987) Long-term persistent infection of macaque monkeys with the simian immunodeficiency virus. J Gen Virol 68: 3183–3189
Chalifoux LV, Ringler DJ, King NW, Sehgal PK, Desrosiers RC, Daniel MD, Letvin NL (1987) Lymphadenopathy in macaques experimentally infected with the simian immunodeficiency virus ( SIV ). Am J Pathol 128: 104–109
Baskin GB (1987) Disseminated cytomegalovirus infection in immunodeficient rhesus monkeys. Am J Pathol 129: 345–352
Kannagi M, Kiyotaki M, Desrosiers RC, Reimann KA, King NW, Waldron LM, Letvin NL (1986) Humoral immune responses to T-cell tropic retrovirus simian T-Iymphotropic virus type III in monkeys with experimentally induced acquired immune deficiency-like syndrome. J Clin Invest 78: 1229–1236
Ward JM, O’Leary TJ, Baskin GB, Benveniste R, Harris CA, Nara PL, Rhods RH (1987) Immunohistochemical localization of human and simian immunodeficiency viral antigens in fixed tissue sections. Am J Pathol 127: 199–205
Ringler DJ, Hunt RD, Desrosiers RC, Daniel MD, Chalifoux LV, King NW (1988) Simian immunodeficiency virus-induced meningoencephalitis: Natural history and retrospective study. Ann Neurol 23 (suppl): S101 - S107
Sharer LR, Baskin GB, Cho E-S, Murphey-Corb M, Blumberg BM, Epstein LG (1988) Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host. Ann Neurol 23 (suppl): S108 - S112
Gallo R, Wong-Staal F, Montagnier L, Haseltine WA, Yoshida M (1988) HIV/HTLV gene nomenclature. Nature 333: 504
Henderson LE, Benveniste RE, Sowder R, Copeland TD, Schultz AM, Oroszlan S (1988) Molecular characterization of gag proteins from simian immunodeficiency virus (SIVM1e). J Virol 62: 2587–2595
di Marzo Veronese F, Copeland TD, DeVico AL, Rahman R, Oroszlan S, Gallo RC, Sarngadharan MG (1986) Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. Science 231: 1289–1291
Kappes JC, Morrow CD, Lee S-W, Jameson BA, Kent SBH, Hood LE, Shaw GM, Hahn BH (1988) Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC. J Virol 62: 3501–3505
Kannagi M, Yetz JM, Letvin NL (1985) In vitro growth characteristics of simian T-lymphotropic virus type III.Proc Natl Acad Sci USA 82:7053–7057
Hoxie JA, Haggarty BS, Bonser SE, Rackowski JL, Shan H, Kanki RI (1988) Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): Evidence for CD4-associated molecules required for infection. J Virol 62: 2557–2568
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Marx, P.A. (1989). Human and Simian Immunodeficiency Viruses in Nonhuman Primates. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8890-6_26
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DOI: https://doi.org/10.1007/978-1-4613-8890-6_26
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