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Analysis of Hepatitis B Virus Gene Expression in Transgenic Mice

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Concepts in Viral Pathogenesis III

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Abstract

The hepatitis B virus (HBV) is a small, enveloped DNA virus (hepadnavirus) that replicates, primarily, in hepatocytes, causes acute and chronic hepatocellular injury, and is associated with the development of primary hepatocellular carcinoma (PHC). Similar viruses have been found in several nonhuman species, including the woodchuck [1], the ground squirrel [2], and the Pekin duck [3]. All hepadnaviruses have the same general genomic organization (for review, see ref. 4) characterized by four open reading frames (ORF) (envelope, nucleocapsid, X, and polymerase), which encode at least seven different polypeptides.

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Authors
  1. Francis V. Chisari
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Editors and Affiliations

  1. Laboratory of Oral Medicine, National Institute of Dental Research, NIH, 20892, Bethesda, Maryland, USA

    Abner Louis Notkins M.D.

  2. Department of Immunology, Scripps Clinic and Research Foundation, 92037, La Jolla, California, USA

    Michael B. A. Oldstone M.D.

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© 1989 Springer-Verlag New York Inc.

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Chisari, F.V. (1989). Analysis of Hepatitis B Virus Gene Expression in Transgenic Mice. In: Notkins, A.L., Oldstone, M.B.A. (eds) Concepts in Viral Pathogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8890-6_19

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  • DOI: https://doi.org/10.1007/978-1-4613-8890-6_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8892-0

  • Online ISBN: 978-1-4613-8890-6

  • eBook Packages: Springer Book Archive

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