Analysis of Hepatitis B Virus Gene Expression in Transgenic Mice

  • Francis V. Chisari


The hepatitis B virus (HBV) is a small, enveloped DNA virus (hepadnavirus) that replicates, primarily, in hepatocytes, causes acute and chronic hepatocellular injury, and is associated with the development of primary hepatocellular carcinoma (PHC). Similar viruses have been found in several nonhuman species, including the woodchuck [1], the ground squirrel [2], and the Pekin duck [3]. All hepadnaviruses have the same general genomic organization (for review, see ref. 4) characterized by four open reading frames (ORF) (envelope, nucleocapsid, X, and polymerase), which encode at least seven different polypeptides.


Hepatitis Albumin Estrogen Codon Polypeptide 


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© Springer-Verlag New York Inc. 1989

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  • Francis V. Chisari

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