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Development of the Lower Limb

  • John A. Ogden

Abstract

Evaluation of the developing lower limb—whether dealing with the multitude of skeletal dysplasias, the highly variable deficiency and duplication situations of congenital deformities, or the manifestations of acquired, traumatic, metabolic, or infectious problems—requires an adequate understanding of developmental chondro-osseous biology. The musculoskeletal and neurovascular components of the leg undergo not only basic differentiation processes, but also specific steps leading to the discrete morphology of the various regions. Major alterations in the initial differentiation will result in focal deficiencies such as absence of the proximal femur or tibial hemimelia. The considerable morphologic variation in these and other hemimelic disorders suggests variable susceptibility to the etiologic factors. Subsequent intrauterine conditions also may affect development, leading to disorders such as tibial pseudarthrosis or amputation from amniotic band syndrome.

Keywords

Femoral Neck Femoral Head Tibial Tuberosity Hyaline Cartilage Ossification Center 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Bardeen CR, Lewis WH: Development of the limbs, body-wall and back in man. Am J Anat 1: 1, 1901.CrossRefGoogle Scholar
  2. 2.
    Burkus JK, Ogden JA: Bipartite primary ossification in the developing human femur. J Pediatr Orthop 2: 63, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Burkus JK, Ogden JA: Development of the distal femoral epiphysis. A microscopic morphological investigation of the zone of Ranvier. J Pediatr Orthop 4: 661, 1984.PubMedCrossRefGoogle Scholar
  4. 4.
    Caplan AI: The molecular basis for limb morphogenesis, in Littlefield JW, de Groucy J (eds): Birth Defects. Proceedings of the Fifth International Conferences. Amsterdam, Excerpta Medica, 1978.Google Scholar
  5. 5.
    Carter DR, Spengler DM: Mechanical properties and composition of cortical bone. Clin Orthop 135: 192, 1978.PubMedGoogle Scholar
  6. 6.
    Cauna N: Concerning the nature and evolution of limbs. J Anat 97: 23, 1963.PubMedGoogle Scholar
  7. 7.
    Cihak R: Ontogenesis of the skeleton and intrinsic muscles of the human hand and foot. Ergeb Anat Entwicklungsgesch 46: 1, 1972.Google Scholar
  8. 8.
    Clark CR, Ogden JA: Development of the menisci of the human knee joint. J Bone Joint Surg Am 65-A: 538, 1983.Google Scholar
  9. 9.
    Enlow DH: The functional significance of the secondary osteon. Anat Rec 142: 230, 1962.Google Scholar
  10. 10.
    Felts WJL: The prenatal development of the human femur. J Anat 94: 1, 1954.CrossRefGoogle Scholar
  11. 11.
    Gardner E: Osteogenesis in the human embryo and fetus, in Bourne GH (ed): The Biochemistry and Physiology of Bone, ed 2, New York, Academic Press, 1971, pp 77–118.Google Scholar
  12. 12.
    Gardner E, Gray DJ: The prenatal development of the human femur. Am J Anat 129: 121, 1970.PubMedCrossRefGoogle Scholar
  13. 13.
    Gardner E, Gray DJ, O’Rahilly R: The prenatal development of the skeleton and joints of the human foot. J Bone Joint Surg 41-A: 847–876, 1959.Google Scholar
  14. 14.
    Gardner E, O’Rahilly R: The early development of the knee joint in staged human embryos. J Anat 102: 289, 1968.PubMedGoogle Scholar
  15. 15.
    Gardner E, O’Rahilly R: The early development of the hip joint in staged human embryos. Anat Rec 172: 451, 1972.Google Scholar
  16. 16.
    Hert J, Kucera P, Vavra M, et al: Comparison of mechanical properties of both primary and haversian bone tissue. Acta Anat (Basel) 61: 412, 1965.CrossRefGoogle Scholar
  17. 17.
    Keats TE: Atlas of Normal Roentgen Variants, ed 3. Chicago, Year Book Medical Publishers, 1979.Google Scholar
  18. 18.
    Keats TE, Joyce JM: Metaphyseal cortical irregularities in children: a new perspective on a multifocal growth variant. Skeletal Radiol 12: 112, 1984.PubMedCrossRefGoogle Scholar
  19. 19.
    Laurenson RD: The chondrification of the human ilium. Anat Rec 748: 197, 1964.CrossRefGoogle Scholar
  20. 20.
    Laurenson RD: The primary ossification of the human ilium. Anat Rec 148: 209, 1964.PubMedCrossRefGoogle Scholar
  21. 21.
    Lawson J, Ogden J, Sella E, et al: The painful accessory navicular. Skeletal Radiol 12: 250, 1984.PubMedCrossRefGoogle Scholar
  22. 22.
    Light TR, McKinstry MP, Schnitzer J, et al: Bone blood flow: regional variation with skeletal maturation, in Arlet J Ficat RP, Hungerford DS (eds): Bone Circulation. Baltimore, Williams & Wilkins Co, 1984.Google Scholar
  23. 23.
    McKinstry R, Schnitzer JE, Light TR, et al: Relationship of 99mTc-MDP uptake to regional osseous circulation in immature and mature dogs. Skeletal Radiol 8: 115, 1982.PubMedCrossRefGoogle Scholar
  24. 24.
    Ogden JA: Changing patterns of proximal femoral vascularity. J Bone Joint Surg. 56–A: 941, 1974.Google Scholar
  25. 25.
    Ogden JA: Proximal fibular growth deformities. Skeletal Radiol 3: 223, 1979.CrossRefGoogle Scholar
  26. 26.
    Ogden JA: Development and growth of the musculoskeletal system, in Albright JA, Brand RA (eds): Scientific Basis of Orthopaedics. (2nd ed.). New York, Appleton and Lange, 1987.Google Scholar
  27. 27.
    Ogden JA: Chondro-osseous development and growth, in Urist M (ed): Fundamental and Clinical Bone Physiology, Philadelphia, JB Lippincott & Co, 1981.Google Scholar
  28. 28.
    Ogden JA: Congenital dysplasia of the hip, in Resnick D,Niwayama G (eds): Diagnosis of Bone and Joint Disorders. Philadelphia, WB Saunders Co, 1981.Google Scholar
  29. 29.
    Ogden JA: Skeletal Injury in the Child. Philadelphia, Lea & Febiger, 1982.Google Scholar
  30. 30.
    Ogden JA: Anomalous multifocal ossification of the os calcis. Clin Orthop 162: 112, 1982.PubMedGoogle Scholar
  31. 31.
    Ogden JA: Development and growth of the hip, in Katz JF, Siffert RS (eds): Management of Hip Disorders in Children. Philadelphia, JB Lippincott Co, 1983.Google Scholar
  32. 32.
    Ogden J A: Radiology of postnatal skeletal development VIII. Distal tibia and fibula. Skeletal Radiol 10: 209, 1983.PubMedCrossRefGoogle Scholar
  33. 33.
    Ogden, JA: The uniqueness of growing bones, in Rockwood CA, Wilkins KE, King RE (eds): Fractures, vol 3—Children. Philadelphia, JB Lippincott Co, 1984.Google Scholar
  34. 34.
    Ogden JA: Growth slowdown and arrest lines. J Pediatr Orthop 4: 409, 1984.PubMedCrossRefGoogle Scholar
  35. 35.
    Ogden JA: Radiology of postnatal skeletal development IX. Proximal tibia and fibula. Skeletal Radiol 11: 169, 1984.PubMedCrossRefGoogle Scholar
  36. 36.
    Ogden J A: Radiology of postnatal skeletal development X. Patella and tibial tuberosity. Skeletal Radiol 11: 246, 1984.PubMedCrossRefGoogle Scholar
  37. 37.
    Ogden JA, Grogan DP: Prenatal development and growth of the musculoskeletal system, in Albright JA, Brand R (eds): The Scientific Basis of Orthopaedics, ed 2. New York, Appleton and Lange, 1987.Google Scholar
  38. 38.
    Ogden JA, Grogan DP, Light TR: Postnatal development and growth of the musculoskeletal system, in Albright JA, Brand RA (eds): The Scientific Basis of Orthopaedics, ed 2. New York, Appleton and Lange, 1987.Google Scholar
  39. 39.
    Ogden JA, McCarthy SM, Jokl P: The painful bipartite patella J Pediatr Orthop 2: 263, 1982.Google Scholar
  40. 40.
    Ogden JA, Moss HL: Pathological anatomy of congenital hip disease, in Progress in Orthopaedic Surgery. New York, Springer-Verlag, 1978.Google Scholar
  41. 41.
    Ogden JA, Tross RB, Murphy MJ: Fractures of tibial tuberosity in adolescents. J Bone Joint Surg 62-A: 205, 1980.Google Scholar
  42. 42.
    O’Rahilly R, Gray DJ, Gardner E: Chondrification in the hands and feet of staged human embryos. Contr Embryol Carneg Inst 36: 183, 1957.Google Scholar
  43. 43.
    O’Rahilly R, Gardner E: The initial appearance of ossification in staged human embroys. Am J Anat 134: 291, 1972.PubMedCrossRefGoogle Scholar
  44. 44.
    O’Rahilly R, Gardner E: The timing and sequence of events in the development of the limbs in the human embryo. Anat Embryol 148: 1, 1975.PubMedCrossRefGoogle Scholar
  45. 45.
    Resnick D, Greenway G: Distal femoral cortical defects, irregularities and excavations. Radiology 143: 345, 1982.PubMedGoogle Scholar
  46. 46.
    Schnitzer JE, McKinstry P, Light TR, et al: Quantitation of regional chondro– osseous circulation in the maturing canine tibia and femur. Am J Physiol 242. H365, 1982.PubMedGoogle Scholar
  47. 47.
    Senior HD: The development of the arteries of the human lower extremity. J Anat 25: 55, 1919.Google Scholar
  48. 48.
    Windle WF: Genesis of somatic motor function in mammalian embryos: A synthesizing article. Physiol Zool 17: 247, 1944.Google Scholar
  49. 49.
    Zwilling E: Limb morphogenesis. Adv Morphog 1: 301, 1961.Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • John A. Ogden

There are no affiliations available

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