Lung Biopsies in Congenital Heart Disease: Computer-Assisted Correlations between Structural and Hemodynamic Abnormalities
The natural history of pulmonary vascular disease differs according to the type of cardiac abnormality. Therefore, pulmonary vascular structure has been analyzed separately in cases of ventricular septal defect (n = 90), complete atrioventricular septal defect without important left atrioventricular valve regurgitation (n = 38), and transposition of the great arteries with ventricular septal defect (n = 28). In all groups, pulmonary arterial pressure and vascular resistance increased in a curvilinear manner with age (Figure 1). Lung tissue was obtained by open lung biopsy procedure in all cases of ventricular septal defect, transposition with ventricular septal defect, and in 71% of cases of atrioventricular septal defect. Pulmonary vascular structure was analyzed using quantitative morphometric techniques, description of arterial wall damage, and a Heath-Edwards classification.
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