Resetting of the Baroreceptor-Heart Rate Reflex in Coarcted Neonates
The long-term effect of periductal aortic coarctation (COARCT) on baroreceptor (BARO) responses and renal hypertension have been reported [1–3]. However, the cardiovascular (CV) effects of COARCT in the neonatal period have not been investigated. We have established a model of COARCT in newborn swine to investigate the pathophysiology of CV regulation in this disease. This paper reports that resetting the BARO-heart rate (HR) reflex occurred along with changes in peripheral circulatory dynamics in the neonatal period.
KeywordsAdrenal Medulla Aortic Coarctation Renal Hypertension Brachial Pressure Descend Aorta
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