Ontogeny of Human T Cell Antigens

  • David F. Lobach
  • Lucinda L. Hensley
  • Winifred Ho
  • Barton F. Haynes


During early fetal ontogeny, the thymic rudiment is formed by a combination of mesodermal, endodermal, and ectodermal elements (1–4). Between 9 and 10 weeks of fetal gestation, the human epithelial thymus is colonized by blood-borne T cell precursors (3–6). Cortical-medullary partitioning of the thymus occurs at 14–15 weeks of gestation and Hassall’s bodies, keratinized epithelial swirls in the medulla, first appear at 15–16 weeks of gestation (3–6). Thus by 16 weeks of gestation, thymic architecture resembles the morphology of postnatal thymus (3–6).


Thymic Epithelial Cell Human Thymus Thymic Epithelium Fetal Gestation Monoclonal Reagent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Haynes, B.F. 1984. The human thymic microenvironment. Adv. Immunol. 36: 87.PubMedCrossRefGoogle Scholar
  2. 2.
    Haynes, B.F., R.M. Scearce, D.F. Lobach, and L.L. Hensley. 1984. Phenotypic characterization and ontogeny of mesodermal-derived and endocrine epithelial components of the human thymic microenvironment. J. Exp. Med. 159: 1149.PubMedCrossRefGoogle Scholar
  3. 3.
    Weller, G.L. 1933. Development of the thyroid, parathyroid and thymus glands in man. Contrib. Embryol. Carnegie Inst. 22: 95.Google Scholar
  4. 4.
    Norris, E.H. 1938. The morphogenesis and histogenesis of the thymus gland in maw In which the origin of the Hassall’s corpuscles of the human thymus is discovered. Contrib. Embryol. Carnegie Inst. 27: 193.Google Scholar
  5. 5.
    Haar, J.L. 1974. Light and electron microscopy of the human fetal thymus. Anat. Rec. 179: 463.PubMedCrossRefGoogle Scholar
  6. 6.
    vonGaudecker, B., and H.K. Muller-Hermelink. 1978. Ontogenetic differentiation of epithelial and non-epithelial cells in the human thymus. Adv. Exp. Med. Biol. 114: 19.Google Scholar
  7. 7.
    Reinherz, E.L., P.C. Kung, G. Goldstein, R.H. Levey, and S.F. Schlossman. 1980. Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc. Natl. Acad. Sci. U.S.A. 77: 1588.PubMedCrossRefGoogle Scholar
  8. 8.
    Reinherz, E.L., and S.F. Schlossman. 1980. The differentiation and function of human T lymphocytes. Cell 19: 821.PubMedCrossRefGoogle Scholar
  9. 9.
    Haynes, B. F. 1984. Phenotypic characterization and ontogeny of the human thymic microenvironment. Clin. Res. 32: 500.PubMedGoogle Scholar
  10. 10.
    Haynes, B.F., E.A. Harden, M.J. Telen, M.E. Hemler, J.L. Strominger, T.J. Palker, R.M. Scearce, and G.S. Eisenbarth. 1983. Differentiation of human T lymphocytes I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. J. Immunol. 131: 1195.PubMedGoogle Scholar
  11. 11.
    Reinherz, E.L., P.C. Kung, G. Goldstein, and S.F. Schlossman 1979. Further characterization of the human inducer T-cell subset defined by monoclonal antibody. J. Immunol. 123: 2894.PubMedGoogle Scholar
  12. 12.
    Bhan, A.K., E.L. Reinherz, S. Poppema, R.T. McCluskey, and S.F. Schloss-man. 1980. Location of T cell and major histocompatibility complex antigens in the human thymus. J. Exp. Med. 152: 771.PubMedCrossRefGoogle Scholar
  13. 13.
    Hamilton, W.J., J.D. Boyd, and H.W. Mossman. 1962. Human embryology. The Williams and Wilkins Company, Baltimore, pp. 119–134.Google Scholar
  14. 14.
    Patten, B.M. 1968. Human embryology. McGraw-Hill, New York, pp. 427–448.Google Scholar
  15. 15.
    Gasser, R.F. 1975. Atlas of human embryos. Harper and Row, Hagerstown, Maryland, pp. 163–240.Google Scholar
  16. 16.
    Hamilton, W.J., J.D. Boyd, and H.W. Mossman. 1962. Human embryology. The Williams and Wilkins Company, Baltimore, pp. 223–224.Google Scholar
  17. 17.
    Haynes, B.F. 1981. Human T lymphocyte antigens as defined by monoclonal antibodies. Immunol. Rev. 57: 127.PubMedCrossRefGoogle Scholar
  18. 18.
    Kung, P.C., G. Goldstein, E.L. Reinherz, and S.F. Schlossman. 1979. Monoclonal antibodies defining distinctive human T cell surface antigens. Science 206: 347.PubMedCrossRefGoogle Scholar
  19. 19.
    Reinherz, E.L., P.C. Kung, G. Goldstein, and S.F. Schlossman. 1979. A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J. Immunol. 123: 131.Google Scholar
  20. 20.
    Reinherz, E.L., P.C. Kung, G. Goldstein, and S.F. Schlossman. 1979. Further characterization of the human inducer T cell subset defined by monoclonal antibody. J. Immunol. 123: 2894.PubMedGoogle Scholar
  21. 21.
    McMichael, A.J., J.R. Pilch, G. Galfre, D.Y. Mason, J.W. Fabre, and Cesar Milstein. 1979. A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur. J. Immunol. 9: 205.PubMedCrossRefGoogle Scholar
  22. 22.
    Dalchau, R., J. Kirkley, and J.W. Fabre. 1980. Monoclonal antibody to a human leukocyte specific membrane glycoprotein probably homologous to the leukocyte common (LC) antigen of the rat. Eur. J. Immunol. 10: 737.PubMedCrossRefGoogle Scholar
  23. 23.
    Haynes, B.F., G.S. Eisenbarth, and A.S. Fauci. 1979. Human lymphocyte antigens: Production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. Proc. Natl. Acad. Sci. U.S.A. 76: 5829.PubMedCrossRefGoogle Scholar
  24. 24.
    McKolanis, J.R., M.J. Borowitz, F.L. Tuck, and R.S. Metzgar. 1984. Membrane antigens of human myeloid cells defined by monoclonal antibodies. In: Leucocyte typing, A. Bernard, L. Boumsell, J. Dausset, C. Milstein, and S. Schlossman, eds. p 387–394. Springer-Verlag, Berlin, Heidelberg.Google Scholar
  25. 25.
    Haynes, B.F., E.G. Reisner, M.E. Hemler, J.L. Strominger, and G.S. Eisenbarth. 1982. Description of a monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross reacting group. Hum. Immunol. 4: 273.PubMedCrossRefGoogle Scholar
  26. 26.
    Lampson, L., and R. Levy. 1980. Two populations of Ia-like molecules on a human B cell line. J. Immunol. 125: 293.PubMedGoogle Scholar
  27. 27.
    Woodcock-Mitchell, J., R. Eichner, W.G. Nelson, and T.-T. Sun. 1982. Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies. J. Cell Biol. 95: 580.PubMedCrossRefGoogle Scholar
  28. 28.
    Haynes, B.F., D.L. Mann, M.E. Hemler, J.A. Schroer, J.A. Shelhamer, G.S. Eisenbarth, C.A. Thomas, H.S. Mostowski, J.L. Strominger, and A.S. Fauci. 1980. Characterization of a monoclonal antibody which defines an immunoregulatory T cell subset for immunoglobulin synthesis in man. Proc. Natl. Acad. Sci. U.S.A. 77: 2914.PubMedCrossRefGoogle Scholar
  29. 29.
    Haynes, B.F., L.L. Hensley, and B.V. Jegasothy. 1982. Differentiation of human T lymphocytes II. Phenotypic difference in skin and blood malignant T cells in cutaneous T cell lymphoma. J. Invest. Dermatol. 78: 323.PubMedCrossRefGoogle Scholar
  30. 30.
    Mann, D.L., B.F. Haynes, C. Thomas, D. Cole, A.S. Fauci, and D.G. Poplack. 1983. Heterogeneity of acute lymphocytic leukemia cell surface markers as detected by monoclonal antibodies. J. Natl. Cancer Inst. 71: 11.PubMedGoogle Scholar
  31. 31.
    Haynes, B.F., R.S. Metzgar, J.D. Minna, and P.A. Bunn. 1981. Phenotypic characterization of cutaneous T-cell lymphoma. Use of monoclonal antibodies to compare with other malignant T cells. New England J. Med. 304: 1319.CrossRefGoogle Scholar
  32. 32.
    Hershfield, M.S., J. Kurtzberg, E. Harden, J.O. Moore, J. Whang-Peng, and B.F. Haynes. 1984. Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2’-deoxycoformcin. Proc. Natl. Acad. Sci. U.S.A. 81: 253.PubMedCrossRefGoogle Scholar
  33. 33.
    Sutherland, D.R., C.E. Rudd, and M.F. Greaves. 1984. Isolation and characterization of a human T lymphocyte associated glycoprotein (gp40). J. Immunol. 133: 327.PubMedGoogle Scholar
  34. 34.
    Meuer, S.C., D.A. Cooper, J.C. Hodgdon, R.E. Hussey, K.A. Fitzgerald, S.F. Schlossman, and E.L. Reinherz. 1983. Identification of the receptor for antigen and major histocompatibility complex on human inducer T-lymphocytes. Science 222: 1240.CrossRefGoogle Scholar
  35. 35.
    Toyonaga, B., Y. Yanagi, N. Sucui-Foca, M. Minden, and T.W. Mak. 1984. Rearrangements of T-cell receptor gene YT35 in human DNA from thymic leukemia T-cell lines and functional T-cell clones. Nature 311: 385.PubMedCrossRefGoogle Scholar
  36. 36.
    Hayward, A.R. 1981. Development of lymphocyte responses and interactions in the human fetus and newborn. Immunol. Rev. 57: 39.PubMedCrossRefGoogle Scholar
  37. 37.
    Torvanen, P., J. Uksila, A. Leino, O. Lassila, T. Hirvonen, and O. Ruuskanen. 1981. Ontogeny of B cell markers in the human fetal liver. Immunol. Rev. 57: 89.CrossRefGoogle Scholar
  38. 38.
    Hofman, F.M., J. Danilovs, L. Husmann, and C.R. Taylor. 1984. Development of mitogen responding T cells and natural killer cells in the human fetus. J. Immunol. 133: 1197.PubMedGoogle Scholar

Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • David F. Lobach
  • Lucinda L. Hensley
  • Winifred Ho
  • Barton F. Haynes

There are no affiliations available

Personalised recommendations