Modulation of T Cell Functions by Monoclonal “Pan T Cell” Antibodies Not Directed Against the T Cell Receptor Complex
Several membrane glycoproteins have been identified by monoclonal antibodies (mAbs) which serve as specific markers for the various human lymphocyte differentiation pathways (1). Some of the T lineage associated antigens are expressed on all mature and immature T lymphocytes, such as the CD2, Tp50 sheep erythrocyte receptor (E-receptor) (1) or the Tp40 antigen recognized by the WT1 mAb (2). Other pan-T markers appear with increasing density during thymic maturation and are fully expressed only when T cells have acquired immunocompetence. Examples are the CD3, Tp20 molecule or the closely associated 90-Kd heterodimer representing the specific antigen receptor on T cells (3). Other pan-T markers are the CD5, Tp67 and the CD6, Tp120 glycoproteins. In normal tissue their expression seems to be restricted to mature T lymphocytes. However, they are not T lineage specific markers, since they can also be found on malignant B lymphocytes and on a small subpopulation of normal B lymphocytes (1).
KeywordsMixed Lymphocyte Reaction Triplicate Culture Lineage Specific Marker Specific Antigen Receptor Leucocyte Typing
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