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Modulation of T Cell Functions by Monoclonal “Pan T Cell” Antibodies Not Directed Against the T Cell Receptor Complex

  • Peter Rieber
  • Gerti Rank
  • Sybille Wirth
  • Martin Wilhelm
  • Eugen Kopp
  • Gert Riethmüller

Abstract

Several membrane glycoproteins have been identified by monoclonal antibodies (mAbs) which serve as specific markers for the various human lymphocyte differentiation pathways (1). Some of the T lineage associated antigens are expressed on all mature and immature T lymphocytes, such as the CD2, Tp50 sheep erythrocyte receptor (E-receptor) (1) or the Tp40 antigen recognized by the WT1 mAb (2). Other pan-T markers appear with increasing density during thymic maturation and are fully expressed only when T cells have acquired immunocompetence. Examples are the CD3, Tp20 molecule or the closely associated 90-Kd heterodimer representing the specific antigen receptor on T cells (3). Other pan-T markers are the CD5, Tp67 and the CD6, Tp120 glycoproteins. In normal tissue their expression seems to be restricted to mature T lymphocytes. However, they are not T lineage specific markers, since they can also be found on malignant B lymphocytes and on a small subpopulation of normal B lymphocytes (1).

Keywords

Mixed Lymphocyte Reaction Triplicate Culture Lineage Specific Marker Specific Antigen Receptor Leucocyte Typing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag New York Inc. 1986

Authors and Affiliations

  • Peter Rieber
  • Gerti Rank
  • Sybille Wirth
  • Martin Wilhelm
  • Eugen Kopp
  • Gert Riethmüller

There are no affiliations available

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