Endocrinology

  • Jawahar L. Tiwari
  • Paul I. Terasaki

Abstract

The first study in 1972 by Finkelstein et al.1 on 28 Caucasian, 10 Mexican, and 6 American Black patients did not show any significant association with A and B loci antigens. A year later, Singal et al.2 studied 50 Canadian patients and found a significantly increased frequency of B15 (36% in the patients vs. 10% in 100 controls). Subsequent reports from several countries have provided data on various racial groups showing an association of juvenile diabetes with several HLA antigens.

Keywords

Testosterone Progesterone Thrombocytopenia Hyperglycemia Aldosterone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Finkelstein S, Zeller E, Walford RL: No relation between HL-A and juvenile diabetes. Tissue Antigens 2:74–77, 1972PubMedCrossRefGoogle Scholar
  2. 2.
    Singal DP, Blajchman MA: Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 22:429–432, 1973PubMedGoogle Scholar
  3. 3.
    Sachs JA, Cudworth AG, Jaraquemada D, Gorsuch AN, Festenstein H: Type 1 diabetes and the HLA-D locus. Diabetologia 18:41–43, 1980PubMedCrossRefGoogle Scholar
  4. 4.
    Farid NR, Sampson L, Noel P, Barnard JM, Davis AJ, Hillman DA: HLA-D-related (DRW) antigens in juvenile diabetes mellitus. Diabetes 28:552–557, 1979PubMedCrossRefGoogle Scholar
  5. 5.
    Solow H, Hidalgo R, Singal DP: Juvenile-onset diabetes: HLA-A, -B, -C, and -DR alloantigens. Diabetes 28:1–4, 1979PubMedCrossRefGoogle Scholar
  6. 6.
    Van De Putte I, Vermylen C, Decraene P, Vlietinck R, Van Den Berghe H: Segregation of HLA B7 in juvenile-onset diabetes mellitus. Lancet ii: 251, 1976CrossRefGoogle Scholar
  7. 7.
    Ilonen J, Herva E, Tiilikainen A, Akerblom HK, Kaivukangas T, Kouvalaimen K: HLA-DW2 as a marker of resistance against juvenile diabetes mellitus. Tissue Antigens 11:144–146, 1978PubMedCrossRefGoogle Scholar
  8. 8.
    Thomsen M, Platz P, Christy M, Nerup J, Ryder LP, Svejgaard A: HLA-D-associated resistance and susceptibility to insulin-dependent diabetes mellitus. Transplant Proc 11:1307–1308, 1979PubMedGoogle Scholar
  9. 9.
    Ludwig H, Schernthaner G, Mayr WR: Is HLA-B7 a marker associated with a protective gene in juvenile-onset diabetes mellitus? N Engl J Med 294:1066, 1976PubMedGoogle Scholar
  10. 10.
    Ilonen J, Herva E, Tiilikainen A, Akerblom HK, Mustonen A, Koivukangas T, et al: HLA genetics of insulin-dependent juvenile-onset diabetes mellitus in northern Finland. Tissue Antigens 15:381–388, 1980PubMedCrossRefGoogle Scholar
  11. 11.
    Cudworth AG, Festenstein H: HLA genetic heterogeneity in diabetes mellitus. Br Med Bull 34:285–289, 1978PubMedGoogle Scholar
  12. 12.
    Platz P, Jakobsen BK, Morling N, Ryder LP, Svejgaard A, Thomsen M, et al: HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus. Diabetologia 21:108–115, 1981PubMedCrossRefGoogle Scholar
  13. 13.
    Barbosa J, Bach FH, Rich SS: Genetic heterogeneity of diabetes and HLA. Clin Genet 21:25–32, 1982PubMedCrossRefGoogle Scholar
  14. 14.
    Svejgaard A, Platz P, Ryder LP: Insulin dependent diabetes mellitus. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1981, pp 638–656Google Scholar
  15. 15.
    Wolf E, Spencer KM, Cudworth AG: The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association. Diabetologia 24:224–230, 1983PubMedCrossRefGoogle Scholar
  16. 16.
    Hammond MG, Asmal AC, Amar MAK: HLA and insulin-dependent diabetes in South African negroes. Diabetologia 19:101–102, 1980PubMedCrossRefGoogle Scholar
  17. 17.
    Briggs BR, Jackson WPU, Dutoit ED, Botha MC: The histocompatibility (HLA) antigen distribution in diabetes in Southern African blacks (Xhosa). Diabetes 29:68–71, 1980PubMedCrossRefGoogle Scholar
  18. 18.
    Patel R, Ansari A, Covarrubias CLP: Leukocyte antigens and disease: III. Association of HLA-B8 and HLA-BW15 with insulin-dependent diabetes in three different population groups. Metabolism 26:487–492, 1977PubMedCrossRefGoogle Scholar
  19. 19.
    Srikanta S, Ahuja MMS, Malaviya AN, Mehra NK, Vaidya MC: Type I (insulin-requiring) diabetes mellitus in North India: HLA and autoimmunity. N Engl J Med 304:1175–1176, 1981PubMedGoogle Scholar
  20. 20.
    Kawa A, Nakazawa M, Sakaguchi S, Nakamura S, Komo Y, Hazeki H, et al: HLA system in Japanese patients with diabetes mellitus. Diabetes 26:591–595, 1977PubMedCrossRefGoogle Scholar
  21. 21.
    Kawa A, Nakazawa M, Kono Y, Sakaguchi S, Nakamura S, Kanehisa T: HLA BW54 and B5 in Japanese diabetics with juvenile-onset and insulin-dependency (with special reference to the family history). Experientia 34:669–670, 1978PubMedCrossRefGoogle Scholar
  22. 22.
    Kawa A, Nakamura S, Kono Y, Maeda Y, Kanehisa T: A negative association of HLA-BW52 with Graves’ disease and insulin-dependent diabetes mellitus with juvenile onset among Japanese population. Experientia 35:547–548, 1979PubMedCrossRefGoogle Scholar
  23. 23.
    Okimoto K, Juji T, Ishiba S, Maruyama H, Tohyama H, Kosaka K: HLA-BW54 (BW22-J, J-l) antigens in juvenile onset diabetes mellitus in Japan. Tissue Antigens 11:418–422, 1978PubMedCrossRefGoogle Scholar
  24. 24.
    Nakao Y, Fukunishi T, Koide M, Akasawa K, Dceda M, Yahata M, et al: HLA antigens in Japanese patients with diabetes mellitus. Diabetes 26:736–739, 1977PubMedCrossRefGoogle Scholar
  25. 25.
    Wakisaka A, Aizawa M, Matsuura N, Nakagawa S, Nakayama E, Okuno A, et al: HLA and juvenile diabetes mellitus in the Japanese. Lancet ii:970, 1976CrossRefGoogle Scholar
  26. 26.
    Sasazuki T, Kohno Y, Iwamoto I, Kosaba K, Okimoto K, Maruyama H, et al: HLA and Graves’ disease or diabetes mellitus in Japan. N Engl J Med 298:630–631, 1978PubMedGoogle Scholar
  27. 27.
    Sakurami T, Nagaoka K, Nabeya N, Imura H, Kuno S: Islet-cell antibodies and HLA type in Japanese insulin-dependent diabetics. Endocrinol Jpn 27:149–152, 1980PubMedCrossRefGoogle Scholar
  28. 28.
    Dornan J, Allan P, Noel EP, Larsen B, Farid NR: Properdin factor B(BF) allele BF(F1) specifies an HLA-B18 diabetogenic haplotype. Diabetes 29:423–427, 1980PubMedCrossRefGoogle Scholar
  29. 29.
    De Mouzon A, Ohayon E, Ducos J: BF and C4 markers for insulin-dependent diabetes in Basques. Lancet ii: 1364, 1979CrossRefGoogle Scholar
  30. 30.
    Bertrams J, Baur MP, Gruneklee D, Gries FA: Association of BfF1, HLA-B18 and insulin-dependent diabetes mellitus. Lancet ii:98, 1979CrossRefGoogle Scholar
  31. 31.
    Deschamps I, Lestradet H, Bonaiti C, Schmid M, Busson M, Benajam A, et al: HLA genotype studies in juvenile insulin-dependent diabetes. Diabetologia 19:189–193, 1980PubMedCrossRefGoogle Scholar
  32. 32.
    Arnaiz-Villena A, Rodriguez De Cordoba S, Dujovne IL, Regueiro JR, Bootello A, Serrano-Rios M: HLA factors in non-insulin-dependent diabetes mellitus. N Engl J Med 303:1065, 1980PubMedGoogle Scholar
  33. 33.
    Farid NR, Barnard JM, Pepper B, Noel EP, Kelly F, Davis AJ, et al: The association of HLA with juvenile diabetes mellitus in Newfoundland. Tissue Antigens 12:215–222, 1978PubMedCrossRefGoogle Scholar
  34. 34.
    Barta L, Simon S, Kosnai I: HLA B8 and BW15 antigens in diabetic children. Acta Paediatr Acad Sci Hung 19:41–44, 1978PubMedGoogle Scholar
  35. 35.
    Ludvigsson J, Safwenberg, Heding LG: HLA-types, C-peptide and insulin antibodies in juvenile diabetes. Diabetologia 13:13–17, 1977PubMedCrossRefGoogle Scholar
  36. 36.
    Cudworth AG, Woodrow JC: Genetic susceptibility in diabetes mellitus: Analysis of the HLA association. Br Med J 2:846–848, 1976PubMedCrossRefGoogle Scholar
  37. 37.
    Cudworth AG, Woodrow JC: Evidence for HL-A linked genes in “juvenile” diabetes mellitus. Br Med J 3:133–135, 1975PubMedCrossRefGoogle Scholar
  38. 38.
    Moller E, Persson B, Sterky G: HLA phenotypes and diabetic retinopathy. Diabetologia 14:155–158, 1978PubMedCrossRefGoogle Scholar
  39. 39.
    Cambon De-Mouzon A, Ohayon E, Hauptmann G, Sevin A, Abbal M, Sommer E, et al: HLA-A, -B, -C, -DR antigens Bf, C4 and glyoxalase I (GLO) polymorphisms in French Basques with insulin-dependent diabetes mellitus (IDDM). Tissue Antigens 19:366–379, 1982PubMedCrossRefGoogle Scholar
  40. 40.
    Pitkänen E, Kuhlback B, Tiilikainen A, Lokki ML, Karkkainen J: HLA-antigen distribution in juvenile diabetics with end-stage nephropathy. Ann Clin Res 13:91–95, 1981PubMedGoogle Scholar
  41. 41.
    Illeni MT, Pellegris G, Del Guercio MJ, Tarantino A, Buseti F, Di Pietro C, et al: HLA antigens in diabetic children. Diabetes 26:870–873, 1977CrossRefGoogle Scholar
  42. 42.
    Schernthaner G, Ludwig H, Mayr WR: Juvenile diabetes mellitus: HLA-antigen frequencies dependent on the age of onset of the disease. J Immu-nogenet 3:117–121, 1976Google Scholar
  43. 43.
    Bertrams J, Baur MP, Gruneklee D, Gries FA. Agerelated association of insulin-dependent diabetes mellitus with BfF1 and HLA-B18, BfF1 haplotype. Diabetologia 21:47–49, 1981PubMedCrossRefGoogle Scholar
  44. 44.
    Zeidler A, Loon J, Frasier SD, Kumar D, Renny R, Terasaki PI: HLA-DRW antigens in Mexican-American and Black-American diabetic patients. Diabetes 29:247–250, 1980PubMedCrossRefGoogle Scholar
  45. 45.
    Pittman WB, Acton RT, Barger B, Bell DS, Go RCP, Murphy CC, et al: HLA-A, -B, and -DR associations in type 1 diabetes mellitus with onset after age forty. Diabetes 31:122–125, 1982PubMedCrossRefGoogle Scholar
  46. 46.
    Morris PJ, Vaughan H, Irvine WJ, McCallum FJ, Gray RS, Campbell CJ, et al: HLA and pancreatic islet cell antibodies in diabetes. Lancet ii:652–653, 1976CrossRefGoogle Scholar
  47. 47.
    Irvine WJ, McCallum CJ, Gray RS, Campbell CJ, Duncan LJP, et al: Pancreatic islet-cell antibodies in diabetes mellitus correlated with duration and type of diabetes, coexistent autoimmune disease, and HLA type. Diabetes 26:138–147, 1977PubMedCrossRefGoogle Scholar
  48. 48.
    Christy M, Nerup J, Bottazzo GF, Donaich D, Platz P, Svejgaard A, et al: Association between HLA-B8 and autoimmunity in juvenile diabetes mellitus. Lancet ii:142–143, 1976CrossRefGoogle Scholar
  49. 49.
    Nerup J, Platz P, Ryder LP, Thomsen M, Svejgaard A: HLA, islet cell antibodies, and types of diabetes mellitus. Diabetes 27(Suppl I):247–250, 1978PubMedGoogle Scholar
  50. 50.
    Richens ER, Quilley J, Hartog M: Immunological features of juvenile onset diabetic patients correlated to HLA type. Clin Exp Immunol 36:198–204, 1979PubMedGoogle Scholar
  51. 51.
    Richens ER, Quilley J, Hartog M: Studies on the frequency and associations of islet-cell antibodies in juvenile diabetes mellitus. Acta Diabetol Lat 15:229–235, 1978PubMedCrossRefGoogle Scholar
  52. 52.
    Lendrum R, Walker G, Cudworth AG, Woodrow JC, Gamble DR: HLA-linked genes and islet-cell antibodies in diabetes. Br Med J 1:1565–1567, 1976PubMedCrossRefGoogle Scholar
  53. 53.
    Batchelor JR, Morris PJ: Juvenile onset diabetes: Joint report. In Bodmer W et al. (eds): Histocompatibility Testing 1977. Munksgaard, Copenhagen, pp 211–213, 1978Google Scholar
  54. 54.
    Mustonen A, Ilonen J, Akerblom HK, Tiilikainen A: An islet cell antibody negative form of insulin-dependent diabetes mellitus (IDD) associated with HLA antigens A9 and Bwl6. Clin Exp Immunol 48:213–217, 1982PubMedGoogle Scholar
  55. 55.
    Ginsberg-Fellner F, Dobersen MJ, Witt ME, Rayfield EJ, Rubinstein P, Notkins AL: HLA antigens, cytoplasmic islet cell antibodies, and carbohydrate tolerance in families of children with insulin-dependent diabetes mellitus. Diabetes 31:292–298, 1982PubMedCrossRefGoogle Scholar
  56. 56.
    Larkins RG, Martin FIR, Tait BD: HLA patterns and diabetic retinopathy. Br Med J 1:1111, 1978PubMedCrossRefGoogle Scholar
  57. 57.
    Bertrams J, Dewald G, Spitznas M, Rittner CH: HLA-A, -B, -C, -DR, Bf, and C2 alleles in insulin-dependent diabetes mellitus with proliferative retinopathy. Immunobiology 158:113–118, 1980PubMedGoogle Scholar
  58. 58.
    Barbosa J, Ramsay RC, Knobloch WH, Cantrill HL, Noreen H, King R, et al.: Histocompatibility antigen frequencies in diabetic retinopathy. Am J Ophthalmol 90:148–153, 1985Google Scholar
  59. 59.
    Barbosa J: Is diabetic microangiopathy genetically heterogeneous? HLA and diabetic nephropathy. Horm Metab Res 11:77–80, 1981Google Scholar
  60. 60.
    Becker B, Shin DH, Burgess D, Kilo C, Miller WV: Histocompatibility antigens and diabetic retinopathy. Diabetes 26:997–999, 1977PubMedCrossRefGoogle Scholar
  61. 61.
    Cove DH, Walker JM, Wells L, Mackintosh P, Wright AD: Are HLA types or BF alleles markers for diabetic retinopathy? Diabetologia 19:402–403, 1980PubMedCrossRefGoogle Scholar
  62. 62.
    Jervell J, Solheim B: HLA-antigens in long standing insulin dependent diabetics with terminal nephropathy and retinopathy with and without loss of vision. Diabetologia 17:391, 1979PubMedCrossRefGoogle Scholar
  63. 63.
    Johnston PB, Kidd M, Middleton D, Greenfield AA, Archer DB, Maguire CJF, Kennedy L: Analysis of HLA antigen association with proliferative diabetic retinopathy. Br J Ophthalmol 66:277–279, 1982PubMedCrossRefGoogle Scholar
  64. 64.
    McCann VJ, McCluskey J, Kay PH, Zilko PJ, Christiansen FT, Dawkins RL: HLA and complement genetic markers in diabetic retinopathy. Diabetologia 24:221, 1983PubMedCrossRefGoogle Scholar
  65. 65.
    Danielsen R, Helgason T, Arnason A, Jonasson F: HLA and retinopathy in type 1 (insulin-dependent) diabetic patients in Iceland. Diabetologia 22:297–298, 1982PubMedCrossRefGoogle Scholar
  66. 66.
    Standi E, Dexel T, Lander T, Albert ED, Scholz S, Greite JH, et al: Association of HLA antigens with severity of diabetic retinopathy in southern Germany. Horm Metab Res 11:81–86, 1981Google Scholar
  67. 67.
    Deckert T, Egeberg J, Frimodt-Moller C, Sander E, Svejgaard A: Basement membrane thickness, insulin antibodies and HLA-antigens in long standing insulin dependent diabetics with and without severe retinopathy. Diabetologia 17:91–96, 1979PubMedCrossRefGoogle Scholar
  68. 68.
    Rolles CJ, Rayner PHW, Mackintosh P: Aetiology of juvenile diabetes. Lancet ii:230, 1975CrossRefGoogle Scholar
  69. 69.
    Garovoy MR, Carpenter CB, Myrberg SM, Gleason RE, Funk IB, Flood TM, et al: Increased incidence of HLA-B8 in jurenile-onset diabetes mellitus. Transplant Proc 9:177–179, 1977PubMedGoogle Scholar
  70. 70.
    Bengsch N, Kobberling J, Eckert G, Willms B: HLA-typing in juvenile diabetes with and without positive family history and in families with one and two diabetic siblings. Diabetologia 15:447–451, 1978PubMedCrossRefGoogle Scholar
  71. 71.
    Ilonen J, Akerblom HK, Tiilikainen A, Mustonen A, Herva E, Koskimie S, et al: Increase of HLA haplotype A9-BW16 in familial insulin-dependent diabetes mellitus in Northern Finland. Acta Diabetol Lat 19:167, 1982PubMedCrossRefGoogle Scholar
  72. 72.
    Kikuchi T, Toyota T, Ouchi E: HLA antigens in juvenile onset diabetes. Tohoku J Exp Med 132:289–293, 1980PubMedCrossRefGoogle Scholar
  73. 73.
    Bertrams J, Jansen, Gruneklee D, Reis HE, Drosy H, and Beyer J, et al: HLA antigens and immunoresponsiveness to insulin in insulin-dependent diabetes mellitus. Tissue Antigens 8:13–19, 1976PubMedCrossRefGoogle Scholar
  74. 74.
    Bertrams J, Jansen FK, Gruneklee D, Reis HE, Drost H, Beyer J, et al: HLA antigen associated immuneresponsiveness to insulin in insulin-dependent diabetes mellitus. Z Immunitaetsforsch 152:309–313, 1976Google Scholar
  75. 75.
    Schernthaner G, Ludwig H, Mayr WR, Willvonseder R: Genetic factors on insulin antibodies in juvenile-onset diabetes. N Engl J Med 295:622, 1976PubMedGoogle Scholar
  76. 76.
    Zeidler A, Frasier SD, Kumar D, Loon J: Histocompatibility antigens and immunoglobulin G insulin antibodies in Mexican-American insulin-dependent diabetic patients. J Clin Endocrinol Me-tab 54:569–573, 1982CrossRefGoogle Scholar
  77. 77.
    Sakurami T, Nabeya N, Nagaoka K, Matsumori A, Kuno S, Honda A: Antibodies to Coxsackie B viruses and HLA in Japanese with juvenile-onset type 1 (insulin-dependent) diabetes mellitus. Dia-betologia 22:375–377, 1982Google Scholar
  78. 78.
    Court S, Parkin M, Roberts DF, Wentzel J: HLA antigens and growth in diabetic children. Ann Hum Biol 9:329–336, 1982PubMedCrossRefGoogle Scholar
  79. 79.
    Singal DP, Perets A, Dolovich J: HLA antigens and serum antibodies to bovine serum albumin. Transplant Proc 11:1864–1865, 1979PubMedGoogle Scholar
  80. 80.
    Serjeantson S, Theophilus J, Zimmet P, Court J, Crossley JR, Elliott RB: Lymphocytotoxic antibodies and histocompatibility antigens in juvenile-onset diabetes mellitus. Diabetes 30:26–29, 1981PubMedCrossRefGoogle Scholar
  81. 81.
    Ludwig H, Mayr WR, Schernthaner G: Glucose-tolerance tests in HL-A-typed relatives of patients with juvenile onset diabetes mellitus. Lancet ii: 1152–1153, 1975CrossRefGoogle Scholar
  82. 82.
    Landgraf R, Landgraf-Leurs MMC, Lander T, Scholz S, Kuntz B, Albert ED: HLA haplotypes and glucose tolerance in families of patients with juvenile-onset diabetes mellitus. Lancet ii:1084–1085, 1976CrossRefGoogle Scholar
  83. 83.
    Larkins RG, Martin HR, Heding LG, Tait BD: Hormonal profile, blood sugar control and HLA patterns in long-term insulin dependent diabetes with and without vascular disease. Aust NZ J Med 8:465–471, 1978CrossRefGoogle Scholar
  84. 84.
    Menser MA, Forrest JM, Honeyman MC, Burgess JA: Diabetes, HL-A antigens, and congenital rubella. Lancet ii: 1508–1509, 1974CrossRefGoogle Scholar
  85. 85.
    Cudworth AG, Woodrow JC: HL-A system and diabetes mellitus. Diabetes 24:345–349, 1975PubMedCrossRefGoogle Scholar
  86. 86.
    Serjeantson S, Kirk RL, Dry PJ, Ryan DP, Court J, Zimmet P, et al: HLA studies in Australian multiple-case families of juvenile onset diabetes mellitus. Med J Aust 1:107–109, 1980PubMedGoogle Scholar
  87. 87.
    Krawisz JE, Palumbo PJ, Taswell HF, Elveback LR: HLA antigens in patients with juvenile diabetes and their first-degree relatives. Mayo Clin Proc 53:782–787, 1978PubMedGoogle Scholar
  88. 88.
    Cudworth AG, Gorsuch AN, Wolf E, Festenstein H: A new look at HLA genetics with particular reference to type-1 diabetes. Lancet ii:389–391, 1979CrossRefGoogle Scholar
  89. 89.
    Nelson PG, Pyke DA, Cudworth AG, Woodrow JC, Batchelor JR: Histocompatibility antigens in diabetic identical twins. Lancet ii: 193–194, 1975CrossRefGoogle Scholar
  90. 90.
    Fitzgerald GA, Drury MI: HLA identity in juvenile onset diabetes. Ir J Med Sci 147:430–434, 1978PubMedCrossRefGoogle Scholar
  91. 91.
    Ryder LP, Christy M, Nerup J, Platz P, Svejgaard A, Thomsen M: HLA studies in diabetics. Adv Exp Med Biol 119:41–50, 1979PubMedGoogle Scholar
  92. 92.
    Christy M, Green A, Christau B, Kronann H, Nerup J, Platz P, et al: Studies of the HLA system and insulin-dependent diabetes mellitus. Diabetes Care 2:209–214, 1979PubMedCrossRefGoogle Scholar
  93. 93.
    Nerup J: HLA studies in diabetes mellitus: A review. Adv Metab Disord 9:263–277, 1978PubMedGoogle Scholar
  94. 94.
    Falk CT, Suciu-Foca N, Rubinstein P: Possible localization of the gene(s) for juvenile diabetes mellitus (JDM) to the HLA region of chromosome 6. Cytogenet Cell Genet 22:298–300, 1978PubMedCrossRefGoogle Scholar
  95. 95.
    Stenszky V, Kozma L, Ambro I, Karmazsin L: Calculation of disease susceptibility gene frequency in insulin-dependent diabetes mellitus. Haematologia 12:141–148, 1978–1979Google Scholar
  96. 96.
    Barbosa J, King R, Noreen H, Yunis EJ: The histocompatibility system in juvenile, insulin-dependent diabetic multiplex kindreds. J Clin Invest 60:989–998, 1977PubMedCrossRefGoogle Scholar
  97. 97.
    Rubinstein P, Suciu-Foca N, Nicholson JF, Fotino M, Molinaro A, Harisiadis L, et al: The HLA system in the families of patients with juvenile diabetes mellitus. J Exp Med 143:1277–1282, 1976PubMedCrossRefGoogle Scholar
  98. 98.
    Barbosa J, Noreen H, King R, Yunis EJ: Genetics of juvenile diabetes. N Engl J Med 298:462, 1978PubMedCrossRefGoogle Scholar
  99. 99.
    Barbosa J, Chern MM, Noreen H, Anderson VE, Yunis EJ: Analysis of linkage between the major histocompatibility system and juvenile, insulin-dependent diabetes in multiplex families. J Clin Invest 62:492–495, 1978PubMedCrossRefGoogle Scholar
  100. 100.
    Barbosa J, Chern MM, Anderson VE, Noreen H, Johnson S, et al: Linkage analysis between the major histocompatibility system and insulin-dependent diabetes in families with patients in two consecutive generations. J Clin Invest 65:592–601, 1980PubMedCrossRefGoogle Scholar
  101. 101.
    Rubinstein P, Suciu-Foca N, Nicholson JF: Genetics of juvenile diabetes mellitus: A recessive gene closely linked to HLA-D with 50 percent penetrance. N Engl J Med 297:1036–1040, 1977PubMedCrossRefGoogle Scholar
  102. 102.
    Suciu-Foca N, Rubinstein P, Nicholson J, Susinno E, Weiner J, Godfrey M, et al: Juvenile diabetes mellitus and the HLA system. Transplant Proc 11:1309–1313, 1979PubMedGoogle Scholar
  103. 103.
    Rubinstein P, Suciu-Foca N: HLA and the genetic aspects of the predisposition to juvenile diabetes mellitus. A follow-up. Adv Exp Med Biol 119:33–40, 1979PubMedGoogle Scholar
  104. 104.
    Clerget-Darpoux F, Bonaiti-Pellie C, Hors J, Deschamps I, Feingold N: Application of the lod score method to detection of linkage between HLA and juvenile insulin-depehndent diabetes. Clin Genet 18:51–57, 1980PubMedCrossRefGoogle Scholar
  105. 105.
    Spielman RS, Baker L, Zmijewski CM: Inheritance of susceptiblity to juvenile onset diabetes. Prog Clin Biol Res 32:567–585, 1979PubMedGoogle Scholar
  106. 106.
    McCluskey J, McCann VJ, Kay PH, Zilko PJ, Christiansen FT, O’Neill GJ, et al: HLA and complement allotypes in type 1 (insulin-dependent) diabetes. Diabetologia 24:162–165, 1983PubMedCrossRefGoogle Scholar
  107. 107.
    Johnston PB, Middleton D, Archer DB, Hadden DR: HLA antigens in proliferative diabetic retinopathy. Int Ophthalmol 3:87–89, 1981PubMedCrossRefGoogle Scholar
  108. 108.
    Weitkamp LR: HLA and disease: Predictions for HLA haplotype sharing in families. Am J Hum Genet 33:776–784, 1981PubMedGoogle Scholar
  109. 109.
    Rubinstein P, Ginsberg-Fellner F, Falk C: Genetics of type I diabetes mellitus: A single, recessive, predisposition gene mapping between HLA-B and GLO. Am J Hum Genet 33:865–862, 1981PubMedGoogle Scholar
  110. 110.
    Green JR, Low HC, Woodrow JC: Inference on inheritance of disease using repetitions of HLA haplotypes in affected siblings. Ann Hum Genet 47:73–82, 1983PubMedCrossRefGoogle Scholar
  111. 111.
    Dunsworth TS, Rich SS, Morton NE, Barbosa J: Heterogeneity of insulin-dependent diabetes-new evidence. Clin Genet 21:233–236, 1982PubMedCrossRefGoogle Scholar
  112. 112.
    Barrai I, Cann HM: Segregation analysis of juvenile diabetes mellitus. J Med Genet 2:8–11, 1965PubMedCrossRefGoogle Scholar
  113. 113.
    Morton NE, Green A, Dunsworth T, Svejgaard A, Barbosa J, Rich SS, et al: Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system. Am J Hum Genet 35:201–213, 1983PubMedGoogle Scholar
  114. 114.
    Green A, Morton NE, Iselius L, Svejgaard A, Platz P, Ryder LP, et al: Genetic studies of insulin-dependent diabetes mellitus: Segregation and linkage analysis. Tissue Antigens 19:213–221, 1982PubMedCrossRefGoogle Scholar
  115. 115.
    Thomson G: A two locus model for juvenile diabetes. Ann Hum Genet 43:383–398, 1980PubMedCrossRefGoogle Scholar
  116. 116.
    Hodge SE, Rotter JI, Lange KL: A three-allele model for heterogeneity of juvenile onset insulin-dependent diabetes. Ann Hum Genet 43:399–412, 1980PubMedCrossRefGoogle Scholar
  117. 117.
    Suarez B, Hodge SE, Reich T: Is juvenile diabetes determined by a single gene closely linked to HLA? Diabetes 28:527–532, 1979PubMedCrossRefGoogle Scholar
  118. 118.
    Clerget-Darpoux BF, Bonaiti-Peddie C, Deschamps I, Hors J, Feingold N: Juvenile insulin-dependent diabete: A possible susceptibility gene in interaction with HLA. Ann Hum Genet 45:199–206, 1981PubMedCrossRefGoogle Scholar
  119. 119.
    Curie-Cohen M: HLA antigens and susceptibility to juvenile diabetes: Do additive relative risks imply genetic heterogeneity. Tissue Antigens 17:136–148, 1981PubMedCrossRefGoogle Scholar
  120. 120.
    Rotter JI: The modes of inheritance of insulin-dependent diabetes mellitus or the genetics of IDDM, no longer a nightmare but still a headache. Am J Hum Genet 33:835–851, 1981PubMedGoogle Scholar
  121. 121.
    Svejgaard A, Ryder LP: HLA genotype distribution and genetic models of insulin-dependent diabetes mellitus. Ann Hum Genet 45:293–298, 1981PubMedCrossRefGoogle Scholar
  122. 122.
    Contu L, Deschamps I, Lestradet H, Jors J, Schmid M, Busson M, et al: HLA haplotype study of 53 juvenile insulin-dependent diabetic (I.D.D.) families. Tissue Antigens 20:123–140, 1982PubMedCrossRefGoogle Scholar
  123. 123.
    Bach FH, Segall M, Rich S, Barbosa J: HLA and susceptibility to type I diabetes. Tissue Antigens 20:28–32, 1982PubMedCrossRefGoogle Scholar
  124. 124.
    Rotter JI, Anderson CE, Rubin R, Congleton JE, Terasaki PI, Rimoin DL: HLA genotypic study of insulin-dependent diabetes. Diabetes 32:169–174, 1983PubMedCrossRefGoogle Scholar
  125. 125.
    Suciu-Foca N, Rubinstein P: Intra-HLA recombinations in juvenile diabetes mellitus. Lancet i:371–372, 1976CrossRefGoogle Scholar
  126. 126.
    Mayr WR, Schernthaner G, Ludwig H: Intra-HLA recombination frequency in juvenile diabetes. Lancet i:865, 1976CrossRefGoogle Scholar
  127. 127.
    Platz P, Thomsen M, Svejgaard A, Cudworth AG, Woodrow JC, Nerup J: More on the genetics of juvenile diabetes. N Engl J Med 298:1200–1201, 1978Google Scholar
  128. 128.
    Hsu SH, Hsu TH, Chase GA, Bias WB: Further data on HLA recombination in juvenile-onset diabetes. Transplant Proc 9:1855–1858, 1977PubMedGoogle Scholar
  129. 129.
    Neel JV: The genetics of juvenile-onset-type diabetes mellitus. N Engl J Med 297:1062–1063, 1977PubMedCrossRefGoogle Scholar
  130. 130.
    Drash AL: The etiology of diabetes mellitus. N Engl J Med 300:1211–1213, 1979PubMedCrossRefGoogle Scholar
  131. 131.
    Yoon JW, Austin M, Onodera T, Notkins AL: Virus-induced diabetes mellitus: Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:173–1179, 1979CrossRefGoogle Scholar
  132. 132.
    Barbosa J: HLA and diabetes mellitus. Lancet i:906–907, 1977CrossRefGoogle Scholar
  133. 133.
    Solow H, Hidalgo R, Blajchman M, Singal DP: HLA-A, -B, -C and B-lymphocyte alloantigens in insulin-dependent diabetes. Tranplant Proc 9:1859–1861, 1977Google Scholar
  134. 134.
    Nerup J, Anderson OO, Christy M, Platz P, Ryder L, Thomsen M, et al: HLA autoimmunity, viruses and the pathogenesis of juvenile diabetes mellitus. Acta Endocrinol (83 Suppl 205):167–175, 1976Google Scholar
  135. 135.
    Bottazzo GF, Doniach D: Pancreatic autoimmunity and HLA antigens. Lancet ii:800, 1976CrossRefGoogle Scholar
  136. 136.
    Woodrow JC: HL-A and its association with clinical disease. Proc Roy Soc Med 68:18–20, 1975Google Scholar
  137. 137.
    Schernthaner G, Ludwig H, Eibl M, Erd W, Packer M, Mayr WK: HLA-system und diabetes mellitus. Schweiz Med Wochenschr 106:514–517, 1976PubMedGoogle Scholar
  138. 138.
    Cudworth AG, Woodrow JC: Genetic susceptibility in diabetic identical twins. Lancet ii:518–519, 1976CrossRefGoogle Scholar
  139. 139.
    Nakazawa M, Hirata Y: Diabetes mellitus and HLA antigens. Nippon Rinsho 36:3193–3196, 1978PubMedGoogle Scholar
  140. 140.
    Cudworth AG: Type I diabetes mellitus. Diabetologia 14:281–291, 1978PubMedCrossRefGoogle Scholar
  141. 141.
    Barta L, Simon S: Role of HLA-B8 and BW15 antigens in diabetic children. N Engl J Med 296:397, 1976Google Scholar
  142. 142.
    De Moerloose PH, Chardonnens X, Vassalli P, Jeannet M: Antigenes HLA-D des lymphocytes B et susceptibilite a certaines maladies. Schweiz Med Wochenschr 107:1461, 1977PubMedGoogle Scholar
  143. 143.
    Williams RM: Ia-like antigens in human autoimmune diseases: HLA and DRW antigens in chronic active hepatitis and diabetes mellitus. In Amos DB, Schwartz RS, Janichi BW (eds): Immune Mechanisms and Disease. Academic Press, New York, 1979, pp 163–177Google Scholar
  144. 144.
    Dippe SE, Bennett PH, Miller M, Maynard JE, Berquist KR: Lack of causal association between Coxsackie B4 virus infection and diabetes. Lancet 1:1314–1317, 1975PubMedCrossRefGoogle Scholar
  145. 145.
    Woodrow JC, Cudworth AG: HL-A8 and W15 in diabetes mellitus. Lancet i:803, 1975CrossRefGoogle Scholar
  146. 146.
    Cathelineau G, Cathelineau L, Hors J, Schmid M, Dausset J: Les groupes HLA dans le diabète a de-but precoce. Nouv Presse Med 5:586, 1976PubMedGoogle Scholar
  147. 147.
    Tattersall RB, Pyke DA: Diabetes in identical twins. Lancet ii: 1120–1125, 1972CrossRefGoogle Scholar
  148. 148.
    Pyke DA, Tattersall RB: Diabetic retinopathy in identical twins. Diabetes 22:613–618, 1973PubMedGoogle Scholar
  149. 149.
    Maugh TH: Diabetes: Epidemiology suggests a viral connection. Science 188:347–351, 1975PubMedCrossRefGoogle Scholar
  150. 150.
    Kromann H, Lernmark A, Vestergaard BF, Egeberg J, Nerup J: The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice. Diabetologia 16:107–114, 1979PubMedCrossRefGoogle Scholar
  151. 151.
    Dimopoulos C, Likourinas M, Melekos M: Diabetes insipidus and hydronephrosis. J Urol 121:689, 1979PubMedGoogle Scholar
  152. 152.
    MacDonald MJ, Curie-Cohen M: HLA in juvenile diabetes. N Engl J Med 302:405–406, 1980PubMedCrossRefGoogle Scholar
  153. 153.
    Rotter JI, Rimon DL: Diabetes mellitus: The search for genetic markers. Diabetes Care 2:215–226, 1979PubMedCrossRefGoogle Scholar
  154. 154.
    Serjeantson S: Distorted HLA segregation or biased ascertainment. Lancet i:40–41, 1980CrossRefGoogle Scholar
  155. 155.
    Lajos B, Erzebet G, Zsuzsa MS: Juvenilis diabetes es addison-kor egyuettes eloefordulasa HLA-B8 antigen pozitivitassal. Orv Hetil 118:931–933, 1977PubMedGoogle Scholar
  156. 156.
    Pointel JP, Sauvanet JP, Dourin P, Debry G, Rafoux C, Streiff F: Diabete insulino-dependant: Frequence des antigenes HLA selon le sexe des malades. Nouv Presse Med 7:1747, 1978PubMedGoogle Scholar
  157. 157.
    Mirouze J, Seignalet J, Selam JL, Lapinski H, Jaffiol C: Antigenes HLA chez les diabetiques insulino-dependants. Nouv Presse Med 5:1628–1630, 1976PubMedGoogle Scholar
  158. 158.
    Schernthaner G, Mayr WR, Pacher M, Ludwig H, Erd W, Eibl M: HL-A8, W15 and T3 in juvenile onset diabetes mellitus. Horm Metab Res 7:521–522, 1975PubMedCrossRefGoogle Scholar
  159. 159.
    O’Regan S: HLA-B8 autoimmune polyendocrinopathy and systemic lupus erythematosus. Can Med Assoc J 121:1168–1169, 1979PubMedGoogle Scholar
  160. 160.
    Cudworth AG Woodrow JC: HL-A antigens and diabetes mellitus. Lancet ii: 1153, 1974CrossRefGoogle Scholar
  161. 161.
    Dvorakova L, Majsky A: HLA antigens in offspring of both diabetic parents. Cas Lek Cesk 118:1294–1296, 1979PubMedGoogle Scholar
  162. 162.
    Neufeld MR, Maclaren NK, Riley WJ: HLA in American Blacks with juvenile diabetes. N Engl J Med 303:111–112, 1980PubMedGoogle Scholar
  163. 163.
    De Moor P, Louwagie A, Van Baelen H, Van De Putte I: Unexplained high transcortin levels in patients with various hematological disorders and in their relatives: A connection between these high transcortin levels and HLA antigen B12. J Clin Endrocrinol Metab 50:421–426, 1980CrossRefGoogle Scholar
  164. 164.
    Serova LD: Changes in incidence of HL-A antigens in diabetes mellitus. Prob Endokrinol (Mosk) 26:12–15, 1980Google Scholar
  165. 165.
    Deschamps I, Hors J, Lestradet H: Inheritance of insulin-dependent diabetes mellitus in relation to the HLA system. Semin Hop Paris 58:153–157, 1982Google Scholar
  166. 166.
    Cahill GF Jr: Current concepts of diabetic complications with emphasis on hereditary factors: A brief review. Prog Clin Biol Res 32:113–125, 1979PubMedGoogle Scholar
  167. 167.
    Palumbo PJ: Classification of diabetes mellitus. Prog Clin Biol Res 32:127–134, 1979PubMedGoogle Scholar
  168. 168.
    Rotter JI: Genetic heterogeneity within diabetes mellitus: A review. Prog Clin Biol Res 32:135–155, 1979PubMedGoogle Scholar
  169. 169.
    Maeda H, Takeuchi F, Juji T, Akanuma Y, Kasuga M, Lee YS, Kosaka K, Tsai SH: HLA-DRW3 in juvenile onset diabetes mellitus in Chinese. Tissue Antigens 15:173–176, 1980PubMedCrossRefGoogle Scholar
  170. 170.
    Zhao T, Chi Z, Wang H, Shen M, Zhou Z, Bu K, et al: HL A and diabetes mellitus in Chinese. Chin Med J 95:609–612, 1982PubMedGoogle Scholar
  171. 171.
    Kirk RL, Ranford PR, Theophilus J, Ahuja HMS, Mehra NK, Vaidya MC: The rare factor BfSl of the properdin system strongly associated with insulin-dependent diabetes in north India. Tissue Antigens 20:303–304, 1982PubMedCrossRefGoogle Scholar
  172. 172.
    Walsh LJ, Cox DW, Ehrlich RM: The HLA-B18, BfF1 in haplotype in type I diabetes. Am J Med Genet 11:337–343, 1982PubMedCrossRefGoogle Scholar
  173. 173.
    Bertrams J, Baur MP, Gruneklee D, Hintzen U: Association of BfF1 and haplotype HLA-B18, BfF1 with insulin-dependent diabetes mellitus. Immunobiology 158:129–133, 1980PubMedGoogle Scholar
  174. 174.
    Moriuchi J, Katagiri M, Wakisaka A, Matsuura N, Maruyama N, Dceda H, et al: Association of B cell alloantigen with juvenile onset diabetes mellitus in the Japanese. Hum Immunol 4:357–362, 1980CrossRefGoogle Scholar
  175. 175.
    Rodey GE, White N, Frazer TE, Duquesnoy RJ, Santiago JV: HLA-DR specificities among Black Americans with juvenile-onset diabetes. N Engl J Med 301:810–812, 1979PubMedCrossRefGoogle Scholar
  176. 176.
    Reitnauer PJ, Roseman JM, Barger BO, Murphy CC, Kirk KA, Acton RT: HLA associations with insulin-dependent diabetes mellitus in a sample of the American Black population. Tissue Antigens 17:286–293, 1981PubMedCrossRefGoogle Scholar
  177. 177.
    Duquesnoy RJ, MacDonald MJ, Mullins P, Hackbarth SA, Traisman HS, Levitsky LL: Increased frequency of HLA-DW3 in North-American Blacks with juvenile onset diabetes. Tissue Antigens 13:369–372, 1979PubMedCrossRefGoogle Scholar
  178. 178.
    Hammond MG, Asmal AC: HLA and insulin dependent diabetes in South African Indians. Tissue Antigens 15:244–248, 1980PubMedCrossRefGoogle Scholar
  179. 179.
    Slater LM, Kershnar A, Golden M, Mosier MA, Arquilla ER: Decreased incidence of HLA-A11 and increased incidence of HLA-B18 in North American population of insulin dependent diabetics. J Clin Lab Immunol 4:91–94, 1980PubMedGoogle Scholar
  180. 180.
    Barbosa J, Noreen H, Emme L, Goetz F, Simmons R, De Leiva A, et al: Histocompatibility (HLA) antigens and diabetic microangiopathy. Tissue Antigens 7:233–237, 1976PubMedCrossRefGoogle Scholar
  181. 181.
    Zimmet P, Kiely P, Cross R, Court J, Bornstein J: HLA patterns in Australian patients with insulin dependent diabetes mellitus (IDDM). Aust NZ J Med 9:633–636, 1979CrossRefGoogle Scholar
  182. 182.
    Vasyukova EA, Gulyaeva ES, Katsnelson LA, Knyazev YA, Mikhailova NA, Zefirova S: HLA-antigens, hormonal profile, insulin antibodies in patients with IDDM with retinopathy. Klin Med (Mosk) 59:42–46, 1981Google Scholar
  183. 183.
    Gray RS, Starkey IR, Rainbow S, Kurtz AB, Ab-del-Khalik A, Urbaniak S, et al: HLA antigens and other risk factors in the development of retinopathy in type 1 diabetes. Br J Ophthalmol 66:280–285, 1982PubMedCrossRefGoogle Scholar
  184. 184.
    Seignalet J, Mirouze J, Jaffiol C, Selam JL, Lapinski H: HL-A in Graves’ disease and in diabetes mellitus insulin-dependent. Tissue Antigens 6:272–274, 1975PubMedCrossRefGoogle Scholar
  185. 185.
    De Moerloose P, Jeannet M, Bally C, Raffoux C, Pointel JP, Sizomenbo P: HLA and DRW antigens in insulin-dependent diabetes. Br Med J 1:823–824, 1978PubMedCrossRefGoogle Scholar
  186. 186.
    MacDonald MJ, Traisman HS, Levitsky LL, Duquesnoy RJ, Müllins P, Hackbarth SA: HLA types in American black juvenile diabetics strong associations with DW3 and DW4. Metabolism 30:533–536, 1981PubMedCrossRefGoogle Scholar
  187. 187.
    Lajos B, Zsuzsa S, Eva GK: Osszefuggesek a HLA antigenek es a gyermekkori diabetes kozott. Orv Hetil 120:2061–2063, 1979Google Scholar
  188. 188.
    Savi M, Neri TM, Zavaroni I, Coscelli C: Marcatori genetici nel diabete giovaniole insulino dipendente. Minerva Med 69:3359–3365, 1978PubMedGoogle Scholar
  189. 189.
    Schober E, Schernthaner G, Mayr WR: HLA-DR antigens in insulin-dependent diabetes. Arch Dis Child 56:227–229, 1981PubMedCrossRefGoogle Scholar
  190. 190.
    Nerup J, Platz P, Andersen OO, Christy M, Lyngsoe J, Poulsen JE, et al: HL-A antigens and diabetes mellitus. Lancet ii:864–866, 1974CrossRefGoogle Scholar
  191. 191.
    Mullins P, Collins J, MacDonald MJ, Duquesnoy RJ: Unusual MLC responses of Black patients with juvenile-onset diabetes. Transplant Proc 11:1879–1881, 1979PubMedGoogle Scholar
  192. 192.
    Reitnauer PJ, Roseman JM, Barger BO, Murphy C, Acton RT: Juvenile onset diabetes in American Blacks. N Engl J Med 302:406, 1980PubMedGoogle Scholar
  193. 193.
    Garovoy MR, Barbosa J, Reddish M, Martin S, Noreen H, Yunis EJ, et al: HLA-DR antigens and unique serologic reactions in juvenile-onset diabetes mellitus. Transplant Proc 10:967–969, 1978PubMedGoogle Scholar
  194. 194.
    Sakurami T, Ueno Y, Nagaoka K, Kuno S, Iwaki Y, Park MS, et al: HLA-DR specifications in Japanese with juvenile-onset insulin-dependent diabetes mellitus. Diabetes 31:105–106, 1982PubMedCrossRefGoogle Scholar
  195. 195.
    Schernthaner G, Ludwig H, Mayr WR: B-lympho-cyte alloantigens and insulin-dependent diabetes mellitus. Lancet ii: 1128, 1977Google Scholar
  196. 196.
    Standi E, Dexel T, Lander T, Albert ED, Scholz S: HLA- antigens and diabetic retinopathy: A different view warranted. Diabetologia 18:79–80, 1980CrossRefGoogle Scholar
  197. 197.
    Bertrams J, Sodomann P, Grosse-Wilde H, Rittner Ch: Two HLA-B/D, DR recombinants in diabetic families: The susceptibility gene traveled with HLA-D, DR fragment. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, 1980, pp 947Google Scholar
  198. 198.
    Berger W, Calabi F, Garotta G, Neri TM, Ceppeliini R: HLA and insulin-dependent diabetes mellitus: High risk for DRW3/DRW4 heterozygous and segregation in a B/DR recombinant family. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, 1980, pp 948Google Scholar
  199. 199.
    Barbosa J, Chavers B, Steffes M, Szalapski E, Cohen RA, Michael AF, et al: Muscle extracellular membrane immunofluorescence and HLA as possible markers of prediabetes. Lancet ii:330–333, 1980CrossRefGoogle Scholar
  200. 200.
    Phillips WR, Pauli R: Simultaneous onset of insulin dependent diabetes mellitus in sibling. Lancet i:807, 1981CrossRefGoogle Scholar
  201. 201.
    Asplund K: Diabetes, mumps and HLA antigens. Lancet ii:807, 1981CrossRefGoogle Scholar
  202. 202.
    Miller AP, Rich S, Barbosa J: Insulin dependent diabetic families: Sex ratio and HLA haplotype segregation. Lancet i:388, 1981CrossRefGoogle Scholar
  203. 203.
    Srikanta S, Mehra NK, Vaidya MC, Malaviya AN, Ahuja MS: HLA antigens in type 1 (insulin-dependent) diabetes mellitus in North India. Metabolism 30:992–993, 1981PubMedCrossRefGoogle Scholar
  204. 204.
    Christy M, Nerup J, Platz P, Thomsen M, Ryder LP, Svejgard A: A review of HLA antigens in longstanding IDDM with and without severe retinopathy. Horm Metab Res 11:73–77, 1981Google Scholar
  205. 205.
    Joron GE, Shuster J, Webb JL: C-peptide and HLA antigens in long-standing juvenile diabetes. Diabetes Care 3:703–704, 1980PubMedGoogle Scholar
  206. 206.
    Bertrams J, Sodomann P, Gries FA, Sachsse B, Jahnke K. Die HLA-association des insulinpflichtigen diabetes mellitus, typ 1. Dtsch Med Wochenschr 106:927–932, 1981PubMedCrossRefGoogle Scholar
  207. 207.
    Hollander PH, Aspiin CM, Kniaz D, Hansen JA, Palmer JP: Beta-cell dysfunction in nondiabetic HLA identical siblings of insulin-dependent diabetics. Diabetes 31:149–153, 1982PubMedCrossRefGoogle Scholar
  208. 208.
    Marks JF, Raskin P, Stastny P: Increase in capillary basement membrane width in parents of children with type 1 diabetes mellitus. Diabetes 30:475–480, 1981PubMedGoogle Scholar
  209. 209.
    Sakurami T, Ueno Y, Iwaki Y, Park MS, Terasaki PI, Saji H: HLA-DR specificities among Japanese with several autoimmune disease. Tissue Antigens 19:129–133, 1982PubMedCrossRefGoogle Scholar
  210. 210.
    Valenta LJ, Bull RW, Hackel E, Bottazzo GF: Correlation of the HLA-A1, B8 haplotypes with circulating autoantibodies in a family with increased incidence of autoimmune disease. Acta Endocrinol 100:143–149, 1982PubMedGoogle Scholar
  211. 211.
    Cox JW, Bourke GM: Benefits of HLA typing a family with diabetes. Aust Paediatr J 17:224–225, 1981PubMedGoogle Scholar
  212. 212.
    Kay PH, McCluskey J, Christiansen FT, Feeney D, McCann VJ, Zilko PJ, et al: Complement allotyping reveals new genetic markers in rheumatoid arthritis and diabetes mellitus. Tissue Antigens 21:159–160, 1983PubMedCrossRefGoogle Scholar
  213. 213.
    Suarez BK, Van Eerdewegh P: Type I (insulin dependent) diabetes mellitus: Is there strong evidence for a non-HLA linked gene? Diabetologia 20:524–529, 1981PubMedCrossRefGoogle Scholar
  214. 214.
    Scholz S, Albeit E: HLA and diseases: Involvement of more than one HLA-linked determinant of disease susceptibility. Immunol Rev 70:77–88, 1983PubMedCrossRefGoogle Scholar
  215. 215.
    Dornan J, Allan P, Noel EP, Sampson L, Farid NR: Alleles of the second component of complement (C2) in insulin-dependent diabetes mellitus. Hum Hered 31:211–213, 1981PubMedCrossRefGoogle Scholar
  216. 1.
    Nelson PG, Pyke DA, Cudworth AG, Woodrow JC, Batchelor JR: Histocompatibility antigens in diabetic identical twins. Lancet ii: 193–194, 1975CrossRefGoogle Scholar
  217. 2.
    Arnaiz-Villena A, Rodriguez De Cordoba S, Dujovne IL, Regueiro JR, Bootello A, Serrano-Rios M: HLA factors in non-insulin-dependent diabetes mellitus. N Engl J Med 303:1065, 1980PubMedGoogle Scholar
  218. 3.
    Patel R, Ansari A, Covarrubias CLP: Leukocyte antigens and disease: III. Association of HLA-B8 and HLA-Bwl5 with insulin-dependent diabetes in three different population groups. Metabolism 26:487–492, 1977PubMedCrossRefGoogle Scholar
  219. 4.
    Sakurami T, Nagaoka K, Nabeya N, Imura H, Kuno S: Islet-cell antibodies and HLA type in Japanese insulin-dependent diabetics. Endocrinol Jpn 27:149–152, 1980PubMedCrossRefGoogle Scholar
  220. 5.
    Kawa A, Nakazawa M, Sakaguchi S, Nakamura S, Komo Y, Hazeki H, et al: HLA system in Japanese patients with diabetes mellitus. Diabetes 26:591–595, 1977PubMedCrossRefGoogle Scholar
  221. 6.
    Kawa A, Nakamura S, Kono Y, Maeda Y, Kanehisa T: A negative association of HLA-BW52 with Graves’ disease and insulin-dependent diabetes mellitus with juvenile onset among Japanese population. Experientia 35:547–548, 1979PubMedCrossRefGoogle Scholar
  222. 7.
    Nakao Y, Fukunishi T, Koide M, Akasawa K, Dceda M, Yahata M, et al: HLA antigens in Japanese patients with diabetes mellitus. Diabetes 26:736–739, 1977PubMedCrossRefGoogle Scholar
  223. 8.
    Nakazawa M, Hirata Y: Diabetes mellitus and HLA antigens. Nippon Rinsho 36:3193–3196, 1978PubMedGoogle Scholar
  224. 9.
    Moriuchi J, Katagiri M, Wakisaka A, Matsuura N, Maruyama N, Ikeda H, et al: Association of B cell alloantigen with juvenile onset diabetes mellitus in the Japanese. Hum Immunol 4:357–362, 1980CrossRefGoogle Scholar
  225. 10.
    Briggs BR, Jackson WPU, Dutoit ED, Botha MC: The histocompatibility (HLA) antigen distribution in diabetes in Southern African blacks (Xhosa). Diabetes 29:68–71, 1980PubMedCrossRefGoogle Scholar
  226. 11.
    Serjeantson SW, Ryan DP, Ram P, Zimmet P: HLA and noninsulin dependent diabetes in Fiji Indians. Med J Aust 1:462–463, 1981PubMedGoogle Scholar
  227. 12.
    Williams RC, Knowler WC, Butler WJ, Pettit DJ, Lisse JR, Bennett PH, et al: HLA-A2 and type 2 (insulin independent) diabetes mellitus in Pima Indians: An association of allele frequency with age. Diabetologia 21:460–463, 1981PubMedCrossRefGoogle Scholar
  228. 13.
    Becker B, Shin DH, Burgess D, Kilo C, Miller WV: Histocompatibility antigens and diabetic retinopathy. Diabetes 26:997–999, 1977PubMedCrossRefGoogle Scholar
  229. 14.
    Cudworth AG, Festenstein H: HLA genetic heterogeneity in diabetes mellitus. Br Med Bull 34:285–289, 1978PubMedGoogle Scholar
  230. 15.
    Cudworth AG, Woodrow JC: Genetic susceptibility in diabetes mellitus: Analysis of the HLA association. Br Med J 2:846–848, 1976PubMedCrossRefGoogle Scholar
  231. 16.
    Tattersall RB, Pyke DA: Diabetes in identical twins. Lancet ii:1120–1125, 1972CrossRefGoogle Scholar
  232. 17.
    Pyke DA, Tattersall RB: Diabetic retinopathy in identical twins. Diabetes 22:613–618, 1973PubMedGoogle Scholar
  233. 18.
    Maugh TH: Diabetes: Epidemiology suggests a viral connection. Science 188:347–351, 1975PubMedCrossRefGoogle Scholar
  234. 19.
    Kromann H, Lernmark A, Vestergaard BF, Egeberg J, Nerup J: The influence of the major histocompatibility complex (H-2) on experimental diabetes in mice. Diabetologia 16:107–114, 1979PubMedCrossRefGoogle Scholar
  235. 20.
    Richens ER, Quilley J, Hartog M: Studies on the frequency and associations of islet-cell antibodies in juvenile diabetes mellitus. Acta Diabetol Lat 15:229–235, 1978PubMedCrossRefGoogle Scholar
  236. 21.
    Rotter JI, Rimon DL: Diabetes mellitus: The search for genetic markers. Diabetes Care 2:215–226, 1979PubMedCrossRefGoogle Scholar
  237. 22.
    Serjeantson S: Distorted HLA segregation or biased ascertainment. Lancet i:40–41, 1980CrossRefGoogle Scholar
  238. 23.
    Dvorakova L, Majsky A: HLA antigens in offspring of both diabetic parents. Cas Lek Cesk 118:1294–1296, 1979PubMedGoogle Scholar
  239. 24.
    Cahill GF Jr: Current concepts of diabetic complications with emphasis on hereditary factors: A brief review. Prog Clin Biol Res 32:113–125, 1979PubMedGoogle Scholar
  240. 25.
    Palumbo PJ: Classification of diabetes mellitus. Prog Clin Biol Res 32:127–134, 1979PubMedGoogle Scholar
  241. 26.
    Rotter JI: Genetic heterogeneity within diabetes mellitus: A review. Prog Clin Biol Res 32:135–155, 1979PubMedGoogle Scholar
  242. 27.
    Singal DP, Blajchman MA: Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 22:429–432, 1973PubMedGoogle Scholar
  243. 28.
    Cudworth AG, Woodrow JC: HL-A system and diabetes mellitus. Diabetes 24:345–349, 1975PubMedCrossRefGoogle Scholar
  244. 29.
    Richens ER, Quilley J, Hartog M: Immunological features of juvenile onset diabetic patients correlated to HLA type. Clin Exp Immunol 36:198–204, 1979PubMedGoogle Scholar
  245. 30.
    Irvine WJ, McCallum CJ, Gray RS, Campbell CJ, Duncan LJP, et al: Pancreatic islet-cell antibodies in diabetes mellitus cprrelated with duration and type of diabetes, coexistent autoimmune disease, and HLA type. Diabetes 26:138–147, 1977PubMedCrossRefGoogle Scholar
  246. 31.
    Morris PJ, Vaughan H, Irvine WJ, McCallum FJ, Gray RS, Campbell CJ, et al: HLA and pancreatic islet cell antibodies in diabetes. Lancet ii:652–653, 1976CrossRefGoogle Scholar
  247. 32.
    Nerup J, Platz P, Andersen OO, Christy M, Lyngsoe J, Poulsen JE, et al: HL-A antigens and diabetes mellitus. Lancet ii:864–866, 1974CrossRefGoogle Scholar
  248. 33.
    Zhao T, Chi Z, Wang H, Shen M, Zhou Z, Bu K, et al: HLA and diabetes mellitus in Chinese. Chin Med J 95:609–612, 1982PubMedGoogle Scholar
  249. 34.
    Majsky A, Dvorakova L: HLA und potentielle dia-betoler (typ 2). Folia Haematol (Leipz) 107:61–64, 1980Google Scholar
  250. 1.
    Nelson PG, Pyke DA: Genetic diabetes not linked to the HLA locus. Br Med J 1:196–197, 1976PubMedCrossRefGoogle Scholar
  251. 2.
    Faber OK, Thomsen M, Binder C, Platz P, Svejgaard A: HLA antigens in a familiy with maturity-onset diabetes mellitus. Acta Endocrinol 88:329–338, 1978PubMedGoogle Scholar
  252. 3.
    Barbosa J, King R, Goetz FC, Noreen H, Yunis EJ: HLA in maturity-onset type of hyperglycemia in the young. Arch Intern Med 138:90–93, 1978PubMedCrossRefGoogle Scholar
  253. 4.
    Barbosa J: No linkage between HLA and maturity onset hyperglycaemia in the young. Diabetologia 24:137, 1983PubMedCrossRefGoogle Scholar
  254. 1.
    Rubinstein P, Walker M, Krassner J, Carrier C, Carpenter C, Dobersen MJ, et al: HLA antigens and islet cell antibodies in gestational diabetes. Hum Immunol 3:271–275, 1981PubMedCrossRefGoogle Scholar
  255. 1.
    Stanley CA, Spielman RS, Zmijewski CM, Baker L: Wolfram syndrome not HLA linked. N Engl J Med 301:1398–1399, 1979PubMedGoogle Scholar
  256. 2.
    Van Eden W, Schreuder GMTH: Wolfram syndrome and HLA. N Engl J Med 302:1263–1264, 1980PubMedGoogle Scholar
  257. 1.
    Spellacy WN, Birk S, Buhi WC: Influence of HLA types on carbohydrate effects of a low-estrogen oral contraceptive. Fértil Steril 33:506–509, 1980PubMedGoogle Scholar
  258. 1.
    D’Apice AJF, Mathews JD, Tait BD, Kincaid-Smith P: Association of HLA antigens with glucose intolerance following renal transplantation. Tissue Antigens 11:423–426, 1978PubMedCrossRefGoogle Scholar
  259. 1.
    Chan SH, Yeo PPB, Lui KF, Wee GB, Woo KT, Lim P, et al: HLA and thyrotoxicosis (Graves’ disease) in Chinese. Tissue Antigens 12:109–114, 1978PubMedCrossRefGoogle Scholar
  260. 2.
    Kawa A, Nakamura S, Nakazawa M, Sakaguchi S, Kawabata T, Maeda Y, et al: HLA-BW35 and B5 in Japanese patients with Graves’ disease. Acta Endocrinol 86:754–757, 1977PubMedGoogle Scholar
  261. 3.
    Grumet FC, Payne RO, Konishi J, Mori T, Kriss JP: HL-A antigens in Japanese patients with Graves’ disease. Tissue Antigens 6:347–352, 1975PubMedCrossRefGoogle Scholar
  262. 4.
    Nakao Y, Kishihara M, Baba YH, Kuma K, Kubonishi T, Imura H: HLA antigens in autoimmune thyroid diseases. Arch Intern Med 138:567–570, 1978CrossRefGoogle Scholar
  263. 5.
    Bech K, Lumholtz B, Nerup J, Thomson M, Platz P, Ryder LP, et al: HLA antigens in Graves’ disease. Acta Endocrinol 86:510–516, 1977PubMedGoogle Scholar
  264. 6.
    Allanic H, Fauchet R, Lorcy Y, Heim J, Gueguen M, Leguerrier AM, et al: Maladie de Basedow: Predominance de l’antigène DRW3. Nouv Presse Med 9:1823–1826, 1980PubMedGoogle Scholar
  265. 7.
    Farid NR, Stone E, Johnson G: Graves’ disease and HLA: Clinical and epidemiologic associations. Clin Endocrinol 13:535–544, 1980CrossRefGoogle Scholar
  266. 8.
    Dahlberg PA, Holmlund G, Karlsson FA, Safwenberg J: HLA-A, -B, -C and -DR antigens in patients with Graves’disease and their correlation with signs and clinical course. Acta Endocrinol 97:42–47, 1981PubMedGoogle Scholar
  267. 9.
    Sasazuki T, Kohno Y, Iwamoto I, Kosaba K, Okimoto K, Maruyama H, et al: HLA and Graves’ disease or diabetes mellitus in Japan. N Engl J Med 298:630–631, 1978PubMedGoogle Scholar
  268. 10.
    Thorsby E, Svejgaard E, Solem JH, Kornstad L: The frequency of major histocompatibility antigens (SD & LD) in thyrotoxicosis. Tissue Antigens 6:54–55, 1975CrossRefGoogle Scholar
  269. 11.
    Balazs CS, Stenszky V, Kozma L, Leovey A: The possible influence of HL A-Al, B8 antigens on the course of Graves’ disease. Biomedicine 29:263–264, 1978PubMedGoogle Scholar
  270. 12.
    Grumet FC, Payne RO, Konishi J, Kriss JP: HL-A antigens as markers for disease susceptibility and autoimmunity in Graves’ disease. J Clin Endocrinol Metab 39:1115–1119, 1974PubMedCrossRefGoogle Scholar
  271. 13.
    Grumet FC, Payne RO, Konishi J, Kriss JP: HL-A antigen frequencies in Graves’ disease. Transplant Proc 7:97–99, 1975Google Scholar
  272. 14.
    Mather BA, Roberts DF, Scalnon MF, Mukhtar ED, Davies TF, Smith BR, et al: HLA antigens and thyroid autoantibodies in patients with Graves’ disease and their first degree relatives. Clin Endocrinol 12:155–163, 1980CrossRefGoogle Scholar
  273. 15.
    Whittingham S, Morris PJ, Martin HR: HL-A8: A genetic link with thyrotoxicosis. Tissue Antigens 6:23–27, 1975PubMedCrossRefGoogle Scholar
  274. 16.
    Farid NR, Barnard JMP Marshall WH: The association of HLA with autoimmune thyroid disease in Newfoundland. The influence of HLA homozygosity in Graves’ disease. Tissue Antigens 8:181–189, 1976PubMedCrossRefGoogle Scholar
  275. 17.
    Schernthaner G, Ludwig H, Schleusener H, Finke R, Korulla P, Mayr WR: TSH-receptor antibodies, HLA-B8 and thyroid autoantibodies in patients with Graves’ disease in therapeutically induced euthyroidism. Experientia 35:1408–1409, 1979PubMedCrossRefGoogle Scholar
  276. 18.
    Singal DP, Perets A, Dolovich J: HLA antigens and serum antibodies to bovine serum albumin. Transplant Proc 11:1864–1865, 1979PubMedGoogle Scholar
  277. 19.
    Mayr WR, Ludwig H, Schernthaner G, Hofer R: HLA CW3 in thyrotoxicosis patients with and without endocrine ophthalmopathy. Tissue Antigens 7:243–246, 1976PubMedCrossRefGoogle Scholar
  278. 20.
    Irvine WJ, Gray RS, Morris PJ, Ting A: Correlation of HLA and thyroid antibodies with clinical course of thyrotoxicosis treated with antithyroid drugs. Lancet ii:898–900, 1977CrossRefGoogle Scholar
  279. 21.
    Jaffiol C, Seignalet J, Baldet L, Robin M, Labinski H, Mirouze J: Systeme HLA et maladie de basedow. Ann Endocrinol (Paris) 37:219–226, 1976Google Scholar
  280. 22.
    Jaffiol C, Seignalet J, Baldet L, Robin M, Lapinski H, Mirouze J: Study of the HLA system in Basedow’s disease. Ann Endocrinol 37:111–112, 1976Google Scholar
  281. 23.
    Jaffiol C, Seignalet J, Baldet L, Robin M, Lapinski H, Mirouze J: HLA B8 and Graves’ disease. Ann Endocrinol 37:219–226, 1976Google Scholar
  282. 24.
    Allannic H, Fauchet R, Lorcy Y, Heim J, Gueguen M, Leguerrier AM, Genetet B: HLA and Graves’ disease: An association with HLA-DRW3. J Clin Endocrinol Metab 51:863–867, 1980PubMedCrossRefGoogle Scholar
  283. 25.
    Sergott RC, Felberg NT, Savino PJ, Blizzard JJ, Schatz NJ, Sanford CA: Association of HLA antigen BW35 with severe Graves’ ophthalmopathy. Invest Ophthalmol Vis Sci 24:124–127, 1983PubMedGoogle Scholar
  284. 26.
    McKenna R, Kearns M, Sugrue D, Drury MI, McCarthy CF: HLA and hyperthyroidism in Ireland. Tissue Antigens 19:97–99, 1982PubMedCrossRefGoogle Scholar
  285. 27.
    Balazs CS, Stenszky V, Kozma L, Szerze P, Leovey A: Connection between HLA-B8 antigen and suppressor T-cell activity in Graves’ disease. Transplant Proc 11:1314, 1979PubMedGoogle Scholar
  286. 28.
    Farid NR, Barnard JM, Bryant DG: HLA and phenylthiocarbamide (PTC) tasting in autoimmune thyroid disease. Tissue Antigens 10:414–416, 1977PubMedCrossRefGoogle Scholar
  287. 29.
    Farid NR, Newton RM, Noel EP, Barnard JM, Marshall WH: The operation of immunological networks in Graves’ disease. Tissue Antigens 12:205–211, 1978PubMedCrossRefGoogle Scholar
  288. 30.
    Noel EP, Sampson L, Pepper BM, Farid NR: Polymorphism of the second component of complement (C2) in Graves’ disease. Hum Hered 30:245–247, 1980PubMedCrossRefGoogle Scholar
  289. 31.
    Larsen B, Pepper B, Barnard JM, Farid NR: HLA/ BF haplotypes in a Newfoundland family. Tissue Antigens 12:39–43, 1978PubMedGoogle Scholar
  290. 32.
    Farid NR, Barnard JM, Marshall WH, Woolfrey I, O’Driscoll RF: Thyroid autoimmune disease in a large Newfoundland family: The influence of HLA. J Clin Endocrinol Metab 45:1165–1172, 1977PubMedCrossRefGoogle Scholar
  291. 33.
    Farid NR, Moens H, Larsen B, Payne R, Saltman K, Fifield F, et al: HLA haplotypes in familial Graves’ disease. Tissue Antigens 15:492–500, 1980PubMedCrossRefGoogle Scholar
  292. 34.
    Raffoux C, Thomas JL, Leclere J, Streiff F, Hartemann P: Lack of HLA association in a familiy with a high incidence of hyperthyroidism. Tissue Antigens 14:274–278, 1979PubMedCrossRefGoogle Scholar
  293. 35.
    Chan SH, Yeo PPB, Cheah JS, Lim P: HLA haplo-type sharing in affected siblings in multiple case Chinese families with thyrotoxicosis. Tissue Antigens 16:258–259, 1980PubMedCrossRefGoogle Scholar
  294. 36.
    Castaner MF, Potau MA, Reus JC, Ercilla MG: HLA antigens in a family with both parents and several siblings affected by Graves’ disease. Acta Endocrinol 102:535–538, 1983Google Scholar
  295. 37.
    Sasazuki T, Nishimura Y, Muto M, Ohta N: HLA-linked genes controlling immune response and disease susceptibility. Immunol Rev 70:51–75, 1983PubMedCrossRefGoogle Scholar
  296. 38.
    Awashima F, Matsuo T, Akaza T, Kuzumaki N, Yoshida TO, Igarashi Y: Hashimoto’s and Graves’ diseases transmitted with the same HLA haplotype. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1980, pp 951Google Scholar
  297. 39.
    Morris PJ, Vaughan H, Tait BD, Mackay IR: Histocompatibility antigens (HLA): Association with immunopathic diseases and with response to microbial antigens. Aust NZ J Med 7:616–624, 1977CrossRefGoogle Scholar
  298. 40.
    Remuzzi G, Livio M, Donati MB, De Gaetano G: Myasthenia gravis, thrombocytopenia and HLA antigens. Ann Intern Med 87:250–251, 1977PubMedGoogle Scholar
  299. 41.
    Seignalet J, Mirouze J, Jaffiol C, Selam JL, Lapinski H: HL-A in Graves’ disease and in diabetes mellitus insulin-dependent. Tissue Antigens 6:272–274, 1975PubMedCrossRefGoogle Scholar
  300. 42.
    Grumet FC, Konishi J, Payne RO, Kriss JP: Association in Japanese of Graves’ disease with the HL-A specificity W5. In Robbins J et al. (eds): Thyroid Research. Excerpta Medica, Amsterdam, 1976, pp 376–379Google Scholar
  301. 43.
    Farid NR, Barnard J, Kutas C, Noel EP, Marshall WH: HL-A antigens in Graves’ disease and Hashimoto’s thyroiditis. Int Arch Allergy Appl Immunol 49:837–842, 1975PubMedCrossRefGoogle Scholar
  302. 44.
    Farid NR, Barnard JM, Sampson L, Noel EP, Marshall WH: The HLA BW4/W6 diallelic system in Graves’ disease. Tissue Antigens 11:394–398, 1978PubMedCrossRefGoogle Scholar
  303. 45.
    Allannic H, Fauchet R, Lorcy Y, Heim J, Gueguen M, Leguerrier A -M, et al: Systeme HLA et maladie de Basedow: Predominance de l’antigene DRW3. Ann Endocrinol (Paris) 41:70–72, 1980Google Scholar
  304. 46.
    Chopra IJ, Solomon DH, Chopra U, Yoshihara E, Terasaki PI, Smith F: Abnormalities in thyroid function in relatives of patients with Graves’ disease and Hashimoto’s thyroiditis. J Clin Endocrinol Metab 45:45–54, 1977PubMedCrossRefGoogle Scholar
  305. 47.
    Ford D, Knight JG, Reeve JK, Stewart RDM: Histocompatibility antigens in Graves’ disease. Aust NZ J Med 6:297–299, 1976Google Scholar
  306. 48.
    Nelson SD, Pollet JE: HL-A antigens and thyrotoxicosis. Tissue Antigens 5:38–40, 1975PubMedCrossRefGoogle Scholar
  307. 49.
    Kawa A, Nakamura S, Kono Y, Maeda Y, Kanehisa T: A negative association of HLA-BW52 with Graves’ disease and insulin-dependent diabetes mellitus with juvenile onset among Japanese population. Experientia 35:547–548, 1979PubMedCrossRefGoogle Scholar
  308. 50.
    Kawahara K, Mitani H, Nokihara M, Mori H: Diseases of internal medicine and HL-A antigens: Basedow disease, Hashimoto’s disease. Nippon Rinsho 36:3189–3192, 1978PubMedGoogle Scholar
  309. 51.
    Farid NR, Sampson L, Noel EP, Barnard JM, Mandeville R, Larsen B, et al: A study of human leukocyte D locus related antigens in Graves’ disease. J Clin Invest 63:108–113, 1979PubMedCrossRefGoogle Scholar
  310. 52.
    Dahlberg PA, Holmlund G, Karlsson FA, Safwenberg J: Prediction of relapse in Graves’ disease. Lancet ii: 1144, 1980Google Scholar
  311. 53.
    Farid NR, Bear JC: Two major genes linked to HLA and Gm, control susceptibility to Graves’ disease. Nature 295:629, 1982PubMedCrossRefGoogle Scholar
  312. 54.
    Tom W, Farid NR: Reduced C4 in HLA-B8 positive patients with Graves’ disease. Hum Hered 31:227–231, 1981PubMedCrossRefGoogle Scholar
  313. 55.
    Stenszky V, Balazs C, Kozma L, Leovey A, Farid NR: HLA control of thyroglobulin-induced blast-transformation in Graves’ disease. Hum Hered 31:322–324, 1981PubMedCrossRefGoogle Scholar
  314. 56.
    Briones-Urbina R, Bear JC, Farid NR: Association of hypergammaglobulinemia G with HLA-DR3 in Graves’ disease. Tissue Antigens 19:20–24, 1982PubMedCrossRefGoogle Scholar
  315. 57.
    Sakurami T, Ueno Y, Iwaki Y, Park MS, Terasaki PI, Saji H: HLA-DR specificities among Japanese with several autoimmune disease. Tissue Antigens 19:129–133, 1982PubMedCrossRefGoogle Scholar
  316. 58.
    Davies TF, Platzer M, Farid NR: Prediction of therapeutic response to radioactive iodine in Graves’ disease using TSH-receptor antibodies and HLA status. Clin Endocrinol 16:183–191, 1982CrossRefGoogle Scholar
  317. 59.
    Schatz H: Die bedeutung der bestimmung von Schilddrusenantikorpern und der HLA-typisierung fur die prognose der hyperthyreose. Med Welt 32:649–652, 1981PubMedGoogle Scholar
  318. 60.
    Bech K, Nerup J, Thomsen M, Platz P, Svejgaard A: HLA and thyrotoxicosis. Lancet ii.1231, 1977Google Scholar
  319. 61.
    Uno H, Sasazuki T, Tamai H, Matsumoto H: Two major genes, linked to HLA and Gm, control susceptibility to Graves’ disease. Nature 292:768–770, 1981PubMedCrossRefGoogle Scholar
  320. 1.
    Miyai K, Mizuta H, Nose O, Fukunishi T, Hirai T, Matsuda S, et al: Increased frequency of HLA-AW24 in congenital hypothyroidism in Japan. N Engl J Med 303:226–227, 1980PubMedGoogle Scholar
  321. 2.
    Cimino P, Banks R, Maclaren N, Rosenbloom E, Riley W, Rosenbloom A, et al: HL A and congenital hypothyroidism. N Engl J Med 303:1177–1178, 1980PubMedGoogle Scholar
  322. 3.
    Oxtoby E, Roberts DF, Wentzel J, Frost G, Parkin JM: Congenital hypothyroidism and HLA. Tissue Antigens 19:1–5, 1982PubMedCrossRefGoogle Scholar
  323. 1.
    Buc M, Nyulassy S, Hnilica P, Busova B, Stefanovic: The frequency of HLA-DW11 determinants in subacute (De Quervain’s) thyroiditis. Tissue Antigens 14:63–67, 1979PubMedCrossRefGoogle Scholar
  324. 2.
    Bech K, Nerup J, Thomsen M, Platz P, Ryder LP, Svejgaard A, et al: Subacute thyroiditis De Quervain: A disease associated with a HLA-B antigen. Acta Endocrinol 86:504–509, 1977Google Scholar
  325. 3.
    Jenkins H, Farid NR: ‘Subacute thyroiditis-like’ syndromes-relation to HLA. Tissue Antigens 13:167–169, 1979PubMedCrossRefGoogle Scholar
  326. 4.
    Nyulassy S, Hnilica P, Stefanovic J: The HL-A system and sub-acute thyroiditis. Tissue Antigens 6:105–106, 1975PubMedCrossRefGoogle Scholar
  327. 5.
    Yeo PPB, Chan SH, Aw TC, Lui KF, Rauff A, Mathew T, et al: HLA and Chinese patients with subacute (De Quervain’s) thyroiditis. Tissue Antigens 17:249–250, 1981PubMedCrossRefGoogle Scholar
  328. 6.
    Majsky A, Feix C: HLA Bw 35 antigen and subacute thyroiditis. Tissue Antigens 9:173, 1977PubMedCrossRefGoogle Scholar
  329. 7.
    Nyulassy S, Hnilica P, Buc M, Guman M, Hirschova V, et al: Subacute (De Quervain’s) thyroiditis: Association with HLA-BW35 antigen and abnormalities of complement system, immunoglobulins and other serum proteins. J Clin Endocrinol Metab 45:270–274, 1977PubMedCrossRefGoogle Scholar
  330. 8.
    Aiginger P, Weissel M, Fritzsche H, Krioss A, Hofer R, Mayr WR: HLA antigens and De Quervain’ thyroiditis. Tissue Antigens 11:59–60, 1978PubMedCrossRefGoogle Scholar
  331. 9.
    Reiner M, Spengler H, Noseda G: HLA-antigene bei thyreoiditis De Quervain. Schweiz Med Wochenschr 106:1834–1836, 1976PubMedGoogle Scholar
  332. 10.
    Nyulassy S, Hnilica P, Hirschova V, and Buc M: Subacute De Quervain’s thyroiditis. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1981, p 717Google Scholar
  333. 1.
    Hawe BS, Walfish PG, Fand NR: HLA antigens in painless thyroiditis with transient hyperthyroidism. Tissue Antigens 19:311–312, 1982PubMedCrossRefGoogle Scholar
  334. 1.
    Nakao Y, Kishihara M, Baba Y, Kuma K, Kubonishi T, Imura H: HLA antigens in autoimmune thyroid diseases. Arch Intern Med 138:567–570, 1978CrossRefGoogle Scholar
  335. 2.
    Kawahara K, Mitani H, Nokihara M, Mori H: Diseases of internal medicine and HL-A antigens: Basedow disease, Hashimoto’s disease. Nippon Rinsho 36:3189–3192, 1978PubMedGoogle Scholar
  336. 3.
    Moens H, Farid NR: Hashimoto’s thyroiditis is associated with HLA-DRW3. N Engl J Med 299:133–134, 1978PubMedCrossRefGoogle Scholar
  337. 4.
    Weissel M, Hofer R, Zasmeta H, Mayr WR: HLA-DR and Hashimoto’s thyroiditis. Tissue Antigens 16:256–257, 1980PubMedCrossRefGoogle Scholar
  338. 5.
    Farid NR, Sampson L, Moens H, Barnard JM: The association of goitrous autoimmune thyroiditis with HLA-DR5. Tissue Antigens 17:265–268, 1981PubMedCrossRefGoogle Scholar
  339. 6.
    Thomsen M, Ryder LP, Bech K, Bliddal H, Feldt-Rasmussen U, Molholm J, et al: HLA-D in Hashimoto’s thyroiditis. Tissue Antigens 21:173–175, 1983PubMedCrossRefGoogle Scholar
  340. 7.
    Bode HH, Dorf ME, Forbes AP: Familial lymphocytic tyhroiditis: Analysis of linkage with histocompatibility and blood groups. J Clin Endocrinol Metab 37:692–697, 1973PubMedCrossRefGoogle Scholar
  341. 8.
    Gordin A, Maenpaa J, Makinen T, Totterman TH, Tiilikainen A: Immunological and genetic markers in a family with Hashimoto’s disease. Clin Endocrinol 11:425–435, 1979CrossRefGoogle Scholar
  342. 9.
    Awashima F, Matsuo T, Akaza T, Kuzumaki N, Yoshida TO, Igarashi Y: Hashimoto’s and Graves’ diseases transmitted with the same HLA haplotype. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1981, pp 951Google Scholar
  343. 10.
    Hoshino K, Inouye H, Unokuchi T, Ito M, Tamaoki N, Tsuji K: HLA and disease in Japanese. In Dausset J, Svejgaard A (eds): HLA and Disease. De L’institut National De La Santé Et De La Recherche Medicale, Paris 1976, p 249Google Scholar
  344. 11.
    Farid NR, Barnard JM, Bryant DG: HLA and phenylthiocarbamide (PTC) tasting in autoimmune thyroid disease. Tissue Antigens 10:414–416, 1977PubMedCrossRefGoogle Scholar
  345. 12.
    Farid NR, Barnard J, Kutas C, Noel EP, Marshall WH: HL-A antigens in Graves’ disease and Hashimoto’s thyroiditis. Int Arch Allergy Appl Immunol 49:837–842, 1975PubMedCrossRefGoogle Scholar
  346. 13.
    Farid NR, Barnard JM, Marshall WH: The association of HLA with autoimmune thyroid disease in Newfoundland. The influence of HLA homozygosity in Graves’ disease. Tissue Antigens 8:181–189, 1976PubMedCrossRefGoogle Scholar
  347. 14.
    Moens H, Barnard JM, Bear J, Farid NR: The association of HLA-B8 with atrophic thyroiditis. Tissue Antigens 13:342–348, 1979PubMedCrossRefGoogle Scholar
  348. 15.
    Chopra IJ, Solomon DH, Chopra U, Yoshihara E, Terasaki PI, Smith F: Abnormalities in thyroid function in relatives of patients with Graves’ disease and Hashimoto’s thyroiditis. J Clin Endocrinol Metab 45:45–54, 1977PubMedCrossRefGoogle Scholar
  349. 16.
    Morris PJ, Vaughan H, Tait BD, Mackay IR: Histocompatibility antigens (HLA): Association with immunopathic diseases and with response to microbial antigens. Aust NZ J Med 7:616–624, 1977CrossRefGoogle Scholar
  350. 17.
    Whittingham S, Youngchaiyud U, Mackay IR, Buckley JD, Morris PJ: Thyrogastric autoimmune disease: Studies on the cell-mediated immune system and histocompatibility antigens. Clin Exp Immunol 19:289–299, 1975PubMedGoogle Scholar
  351. 18.
    Sakurami T, Ueno Y, Iwaki Y, Park MS, Terasaki PI, Saji H: HLA-DR specificities among Japanese with several autoimmune disease. Tissue Antigens 19:129–133, 1982PubMedCrossRefGoogle Scholar
  352. 19.
    Bliddal H, Bech K, Feldt-Rasmussen U, Thomsen M, Ryder L, Hansen JM, et al: Thyroid-stimulating immunoglobulins in Hashimoto’s thyroiditis measured by radioreceptor assay and adenylate cyclase stimulation and their relationship to HLA-D alleles. J Clin Endocrinol Metab 55:995–998, 1982PubMedCrossRefGoogle Scholar
  353. 20.
    Valenta LJ, Bull RW, Hackel E, Bottazzo GF: Correlation of the HLA-A1, B8 haplotypes with circulating autoantibodies in a family with increased incidence of autoimmune disease. Acta Endocrinol 100:143–149, 1982PubMedGoogle Scholar
  354. 1.
    Majsky A, Feix C: HLA antigens and myxedema. Tissue Antigens 10:119–120, 1977PubMedCrossRefGoogle Scholar
  355. 1.
    Farid NR, Larsen B, Payne R, Noel EP, Sampson L: Polyglandular autoimmune disease and HLA. Tissue Antigens 16:23–29, 1980PubMedCrossRefGoogle Scholar
  356. 2.
    Eisenbarth G, Wilson P, Ward F, Lebovitz HE: HLA type and occurrence of disease in familial polyglandular failure. N Engl J Med 298:92–94, 1978PubMedCrossRefGoogle Scholar
  357. 3.
    Eisenbarth GS, Wilson PW, Ward F, Buchley C, Lebovitz H: The polyglandular failure syndrome: disease inheritance, HLA type, and immune function. Ann Intern Med 91:528–533, 1979PubMedGoogle Scholar
  358. 4.
    Farid NR: Polyglandular failure syndrome. Ann Intern Med 92:442–443, 1980PubMedGoogle Scholar
  359. 5.
    Brueton MJ, Chapel HM, Mackintosh LP: A study of genetic markers in a family with polyendocrine disease. Tissue Antigens 15:101–103, 1980PubMedCrossRefGoogle Scholar
  360. 1.
    Dupont B, Pollack MS, Levine LS, O’Neill GJ, Hawkins BR, New MI: Congenital adrenal hyperplasia. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1981, pp. 693–706Google Scholar
  361. 2.
    Brautbar C, Roesler A, Landau H, Cohen I, Nelken D, Cohen T, et al: No linkage between HLA and congenital adrenal hyperplasia due to 11-β-hydroxyl-ase deficiency. N Engl J Med 300:205–206, 1979PubMedGoogle Scholar
  362. 3.
    Glenthoj A, Dankjaer-Nielsen M, Stamp J, Svejgaard A: HLA and congenital adrenal hyperplasia due to 11-hydroxylase deficiency. Tissue Antigens 14:181–182, 1979PubMedCrossRefGoogle Scholar
  363. 4.
    Rochiccioli P, De Mouzon A, Gallegos D, Dutau G, Parra MT, Ohayon E: Liaison genetique entre HLA et hyperplasie virilisante des surrenales: Etude de 12 cas. J Hum Genet 28:201–205, 1980Google Scholar
  364. 1.
    Mantero F, Scaroni C, Pasini CV, Fagiolo U: No linkage between HLA and congenital adrenal hyperplasia due to 17-alpha hydroxylase deficiency. N Engl J Med 303:530, 1980PubMedGoogle Scholar
  365. 2.
    D’Armiento M, Reda G, Bisignani G, Tabolli S, Cappellaci S, Lulli P, et al.: No linkage between HLA and congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency. N Engl J Med 308:970–971, 1983PubMedCrossRefGoogle Scholar
  366. 1.
    Dupont B, Oberfield SE, Smithwick EM, Lee TD, Levine LS: Close genetic linkage between HLA and congenital adrenal hyperplasia (21-hydroxylase deficiency). Lancet ii:1309–1312, 1977CrossRefGoogle Scholar
  367. 2.
    Price DA, Klouda PT, Harris R: HLA and congenital adrenal hyperplasia linkage confirmed. Lancet i:930–932, 1978CrossRefGoogle Scholar
  368. 3.
    Weitkamp LR, Bryson M, Bacon GE: HLA and congenital adrenal hyperplasia linkage confirmed. Lancet i:930–932, 1978Google Scholar
  369. 4.
    Levine LS, Zachmann M, New MI, Prader A, Pollack MS, O’Neill GJ, et al: Genetic mapping of the 21-hydroxylase-deficiency gene within the HLA linkage group. N Engl J Med 299:911–915, 1978PubMedCrossRefGoogle Scholar
  370. 5.
    Sobel D, Gutai JP, Jones JC, Wagener DK, Smith W: Detection of heterozygote of 21-hydroxylasede-12. ficiency. Lancet i:47, 1980CrossRefGoogle Scholar
  371. 6.
    Klouda PT, Harris R, Price DA: Linkage and association between HLA and 21-hydroxylase deficiency. J Med Genet 17:337–341, 1980PubMedCrossRefGoogle Scholar
  372. 7.
    Betuel H, Fauchet R, Gebuhrer L, Freidel C, Bouhallier O: Informative families for the location of the congenital adrenal hyperplasia gene. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA 14. Tissue Typing Laboratory, Los Angeles, 1981, pp 941Google Scholar
  373. 8.
    Bercovici JP, Khoury S, Le Fur JM, Saleun JP, Nahoul K, Scholler R: Hormonal profiles of heterozygotes in humans for 21-hydroxylase deficiency 15. defined by HLA B typing. J Steroid Biochem 14:1049–1054, 1981PubMedCrossRefGoogle Scholar
  374. 9.
    Bias WB, Urban MD, Migeon CJ, Hsu SH, Lee PA: Intra-HLA recombinations localizing the 21-16. hydroxylase deficiency gene within the HLA complex. Hum Immunol 2:139–145, 1981PubMedCrossRefGoogle Scholar
  375. 10.
    Bercovici JP, Tater D, Khoury S, Le Fur JM, Saleun JP, Nahoul K, et al: Profil hormonal et typage 17. HLA des sujets adultes de 7 familles d’hyperplasie congenitale des surrenales par deficit en 21-hydroxylase. Ann Endocrinol 43:203–211, 1982Google Scholar
  376. 11.
    Chrousos GP, Loriauz DL, Mann D, Cutler Jr GB: Late-onset 21-hydroxylase deficiency is an allelic 18. variant of congenital adrenal hyperplasia characterized by attentuated clinical expression and different HLA haplotype associations. Horm Res 16:193–200, 1982PubMedCrossRefGoogle Scholar
  377. 12.
    Cruz-Marin F, Raffoux C, Gilgenkrantz S, Janot C, Streiff F, Pierson M: Remarques sur la liaison entre Thyperplasie congenitale des surrenales par deficit en 21 hydroxylase et des groupes d’histocompatibi-lite HLA. J Hum Genet 29:103–113, 1981Google Scholar
  378. 13.
    Boue A, Boue J, Couillin P: Hyperplasie congenitale des surrenales et antigenes HLA. J Hum Genet 28:195–200, 1980Google Scholar
  379. 14.
    Dupont B, Pollack MS, Levine LS, O’Neill GJ, Hawkins BR, New MI: Congenital adrenal hyperplasia. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1981, pp 693–706Google Scholar
  380. 15.
    Petersen KE, Svejgaard A, Nielsen MD, Dissing J: Heterozygotes and cryptic patients in families of patients with congenital adrenal hyperplasia (21-hydroxylase deficiency). Horm Res 16:151–159, 1982PubMedCrossRefGoogle Scholar
  381. 16.
    Coullin P, Rappaport R, Kuttenn F, Canlorbe P, Hors J, Marcelli-Barge A, et al: HLA and 21-hydroxyiase deficiency in the French population. Tissue Antigens 19:100–107, 1982CrossRefGoogle Scholar
  382. 17.
    Pollack MS, Levine LS, O’Neill GJ, Pang S, Lorenzen F, Kohn B, et al: HLA linkage and B14, DR1, BfS haplotype association with the genes for late onset and cryptic 21-hydroxylase deficiency. Am J Hum Genet 33:540–550, 1981PubMedGoogle Scholar
  383. 18.
    Rosenmann A, Schumert Z, Theodor R, Cohen T, Brautbar C: Amniotic 17 alpha hydroxyprogesterone and HLA typing for the prenatal diagnosis of 21 alpha hydroxylase deficiency-congenital adrenal hyperplasia. Am J Med Genet 6:295–300, 1980PubMedCrossRefGoogle Scholar
  384. 19.
    Yang SY, Levine LS, Zachmann M, New MI, Prader A, Oberfield SE, et al: Mapping of the 21-hydroxylase deficiency gene within the HLA linkage group. Transplant Proc 10:753–755, 1978PubMedGoogle Scholar
  385. 20.
    Murtaza LM, Hughes IA, Sibert JR, Balfour IC: HLA and congenital adrenal hyperplasia. Lancet ii:524, 1978Google Scholar
  386. 21.
    Laron Z, Pollack MS, Zamir R, Roitman A, Dickerman Z, Levine LS, et al: Late onset 21-hydroxylase deficiency and HLA in the Ashkenazi population: A new allele. Hum Immunol 1:55–66, 1980PubMedCrossRefGoogle Scholar
  387. 22.
    Laron Z, Pollack MS, Zamir R, Roitman A, Dickerman Z, Kaufman H, et al: Late-onset 21-hydroxylase deficiency and HLA. Isr J Med Sci 16:411–412, 1982Google Scholar
  388. 23.
    Pollack MS, Levine LS, Pang S, Owens RP, Nitowsky HM, Maurer D, et al: Prenatal diagnosis of congenital adrenal hyperplasia (21-hydroxylase deficiency) by HLA typing. Lancet i:1107–1108, 1979CrossRefGoogle Scholar
  389. 24.
    Couillin P, Nicolas H, Boue J, Boue A: HLA typing of amniotic-fluid cells applied to prenatal diagnosis of congential adrenal hyperplasia. Lancet i:1076, 1979CrossRefGoogle Scholar
  390. 25.
    Rosenmann A, Schumert Z, Theodor R, Cohen T, Brautbar C: Amniotic 17-alpha hydroxyprogesterone and HLA typing for the prenatal diagnosis of 21-alpha hydroxylase deficiency — congenital adrenal hyperplasia. Am J Med Genet 6:295–300, 1980PubMedCrossRefGoogle Scholar
  391. 26.
    Pollack MS, Maurer D, Levine LS, Mew MI, Pang S, Duchon MA, et al: HLA typing of amniotic cells: The prenatal diagnosis of congenital adrenal hyperplasia (21-OH-deficiency type). Transplant Proc 11:1726–1728, 1979PubMedGoogle Scholar
  392. 27.
    Zappacosta S, De Felice M, Minozzi M, Lombardi G, Valentino R, Vanacore G: HLA and congenital adrenal hyperplasia. Lancet ii:524, 1978CrossRefGoogle Scholar
  393. 28.
    Lorenzen F, Pang S, New M, Pollack M, Oberfield S, Dupont B, et al: Studies of C-21 and C-19 steroids and HLA genotyping in siblings and parents of patients with congenital adrenal hyperplasia. J Clin Endocrinol Metab 50:572–577, 1980PubMedCrossRefGoogle Scholar
  394. 29.
    Zachmann M, Prader A: Unusual heterozygotes of congenital adrenal hyperplasia due to 21-hydroxylase deficiency confirmed by HLA tissue typing. Acta Endocrinol 92:542–546, 1979PubMedGoogle Scholar
  395. 30.
    O’Neill GJ, Pollack MS, Yang SY, Levine LS, New MI, Dupont B: Gene frequencies and genetic linkage disequilibrium for the HLA-linked genes BF, C2, C4s, C4f, 21-hydroxylase deficiency, and glyoxalase I. Transplant Proc 11:1713–1715, 1979PubMedGoogle Scholar
  396. 31.
    Wurster KG, Clemens GE, Schunter F, Heilbrunner H: Moglichkeit der pranatalen diagnostik eines adrenogenitalen syndroms durch HLA-typisierung kultivierter amnionzellen. Dtsch Med Wochenschr 104:526, 1979PubMedGoogle Scholar
  397. 32.
    Hughes IA, Laurence KM: Antenatal diagnosis of congenital adrenal hyperplasia. Lancet ii:7–8, 1979CrossRefGoogle Scholar
  398. 33.
    Rubinstein P: Other markers in the HLA linkage group. Clin Immunobiol 4:183–194, 1980Google Scholar
  399. 34.
    Pollack MS, Levine L, Zachmann M, Prader A, New M, Oberfield S, et al: Possible genetic linkage disequilibrium between HLA and the 21-hydroxylase deficiency gene (congenital adrenal hyperplasia). Transplant Proc 11:1315–1316, 1979PubMedGoogle Scholar
  400. 35.
    Lisa L, Ivaskova E, Sajdlova H, Kupkova L: Congenital adrenogenital syndrome — its prognosis and immunogenetic relations. Cesk Pediatr 37:58–61, 1982PubMedGoogle Scholar
  401. 36.
    Couillin P, Kottler-Missonnier ML, Grisard MC, Hors J, Feingold J, Boue J, et al: HLA-A, B, C, DR alleles in congenital adrenal hyperplasia. Hum Genet 53:389–392, 1980PubMedCrossRefGoogle Scholar
  402. 37.
    Pollack MS, New MI, O’Neill GJ, Levine LS, Callaway C, Pang S, et al: HLA genotypes and HLA-linked genetic markers in Italian patients with classical 21 hydroxylase deficiency. Hum Genet 58:331–337, 1981PubMedCrossRefGoogle Scholar
  403. 38.
    Klouda PT, Harris R, Price DA: HLA and congenital adrenal hyperplasia. Lancet ii:1046, 1978CrossRefGoogle Scholar
  404. 39.
    Stuckey MS, Boyne P, MacDonald WB, Christiansen FT, Houliston JB, Dawkins R: HLA typing and ACTH stimulation in the detection of carriers for 21-hydroxylase deficiency. Aust NZ Med 10:552–554, 1980CrossRefGoogle Scholar
  405. 40.
    Mayer S, Tongio MM, Flori J, Bonardi JM, North ML, Klein J, et al: HLA and congenital adrenal hyperplasia. In Terasaki PI (ed): Histocompatibility Testing 1980. UCLA Tissue Typing Laboratory, Los Angeles, 1981, p 940Google Scholar
  406. 41.
    Mauseth RS, Hansen JA, Smith EK, Giblett ER, Kelley VC: Detection of heterozygotes for congenital adrenal hyperplasia: 21-Hydroxylase deficiency—a comparison of HLA typing and 17-OH progesterone to ACTH infusion. J Pediatr 97:749–753, 1980PubMedCrossRefGoogle Scholar
  407. 42.
    Kauschansky A, Kaufman H, Zamir R, Elian E: Late onset adrenal hyperplasia (21-hydroxylase deficiency): 17-OH progesterone response to ACTH stimulation and HLA typing. Hormone Res 14:73–78, 1981PubMedCrossRefGoogle Scholar
  408. 43.
    Rochiccioli P, De Mouzon A, Gallegos D, Dutau G, Parra MT, Ohayon E: Liaison genetique entre HLA et hyperplasie virilisante des surrenales: Etude de 12 cas. J Hum Genet 28:201–205, 1980Google Scholar
  409. 44.
    Bercovici JP, Khoury S, Le Fur JM, Saleun JP, Nahoul K, Scholler R: Steroid pattern and HLA genotype in parents and siblings of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Pathol Biol (Paris) 29:380–381, 1981Google Scholar
  410. 1.
    Lada G, Gyodi E, Glaz E: HLA antigens in patients with adrenocortical hyperfunction. Acta Med Acad Sci Hung 34:213–226, 1977PubMedGoogle Scholar
  411. 1.
    Platz P, Ryder L, Staub Nielsen L, Svejgaard A, Thomsen M, Nerup J, et al: HL-A and idiopathic Addison’s disease. Lancet ii:289, 1974CrossRefGoogle Scholar
  412. 2.
    Ludwig H, Mayr WR, Pacher M, Schernthaner G, Koller K, Ebil M, et al: HL-A antigens in idiopathic Addison’s disease. Z Immunitaetsforsch Bd 149:423–427, 1975Google Scholar
  413. 3.
    De Bruyere M, Vandeput Y, Crabbe J: Primary adrenocortical failure and the HLA system. Horm Res 16:345–352, 1982CrossRefGoogle Scholar
  414. 4.
    Valenta LJ, Bull RW, Hackel E, Bottazzo GF: Correlation of the HLA-A1,B8 haplotypes with circulating autoantibodies in a family with increased incidence of autoimmune disease. Acta Endocrinol 100:143–149, 1982PubMedGoogle Scholar
  415. 1.
    Dornan J, Barnard JM, Farid NR: Lack of close linkage of hypogonadotropic hypogonadism with HLA. Tissue Antigens 15:510–511, 1980PubMedCrossRefGoogle Scholar
  416. 2.
    Klouda PT, Donnai D, Harris R: HLA study in a live-born infant with triploidy of paternal origin. Tissue Antigens 17:240–242, 1981PubMedCrossRefGoogle Scholar
  417. 1.
    Jung RT, Joysey VC, Davie M, Chalmers TM: HLA in multiple endocrine adenomatosis (type I). Tissue Antigens 13:317–318, 1979PubMedCrossRefGoogle Scholar
  418. 2.
    Groussin P, Renard JP, Chavanne D, Bertrand G, Avril J, Simier JL: Antigenes HLA d’une famille ayant une adenomatose polyendocrinienne de type 1. Nouv Presse Med 9:1033–1034, 1980PubMedGoogle Scholar
  419. 3.
    Farid NR, Buehler S, Russell NA, Maroun FB, Allerdice P, Smythe HS: Prolactinomas in familial multiple endocrine neoplasia syndrome type I: Relationship to HLA and carcinoid tumors. Am J Med 69:874–880, 1980PubMedCrossRefGoogle Scholar
  420. 1.
    Luton JP, Baulieu F, Fumeron F, Hors J, Bricaire H: HLA tracers and Cushing’s syndrome. Ann Endocrinol (Paris) 42:2–9, 1981Google Scholar
  421. 1.
    Brautbar C, Theodor R, Sack J, Levene C, Dupont B, Levine LS, et al: HLA in a selective aldosterone biosynthetic defect due to type 2 corticosterone methyl-oxidase deficiency. Tissue Antigens 17:212–216, 1981PubMedCrossRefGoogle Scholar
  422. 1.
    Walfish PG, Gottesman IS, Shewchuk AB, Bain J, Hawe BS, Farid NR: Association of premature ovarian failure with HLA antigens. Tissue Antigens 21:168–169, 1983PubMedCrossRefGoogle Scholar
  423. 1.
    Gautier O, Petiteau PY, Lasfargues G, Hainault T, Fromantin M: Y a-t-il correlation entre marqueurs HLA et syndrome de Klinefelter? Nouv Presse Med 11:130–131, 1982Google Scholar
  424. 1.
    De Moor P, Louwagie A: Association of aberrant transcortin levels with HLA antigens of the B and C loci. J Clin Endocrinol Metab 51:868–872, 1980PubMedCrossRefGoogle Scholar
  425. 1.
    Gerencer M, Tajic M, Kerhin-Brkljacic V, Kastelan A: An association between serum testosterone level and HLA phenotype. Immunol Lett 4:155–158, 1982PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 1985

Authors and Affiliations

  • Jawahar L. Tiwari
    • 1
  • Paul I. Terasaki
    • 2
  1. 1.Center for The Health SciencesUCLA Tissue Typing LaboratoryLos AngelesUSA
  2. 2.UCLA Hospital and ClinicsLos AngelesUSA

Personalised recommendations