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Morphology of Drug-Induced Ocular Changes

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Pathology of the Eye
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Abstract

The numerous side effects of drugs on the eye have been well documented in detailed monographs.47b,54,59 It is the purpose of this chapter to give a brief overview of selected morphologic changes to various ocular tissues, many of which have been partially considered in previous chapters (see Chapters 6–15).24

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References

  1. Aichmair H: Effects of drugs on extraocular muscles. In: Dikstein S (ed): Drugs and Ocular Tissues, p. 1. Karger, Basel, 1977

    Google Scholar 

  2. Anderson DR: Experimental alpha-chymotrypsin glaucoma studied by scanning electron microscopy. Am J Ophthalmol 71:470, 1971

    PubMed  CAS  Google Scholar 

  3. Apple DJ, Bennett TO: Multiple systemic and ocular malformations associated with maternal LSD usage. Arch Ophthalmol 92:301, 1974

    PubMed  CAS  Google Scholar 

  4. Apt L, Gaffney WL: Congenital eye abnormalities from drugs during pregnancy. In: Leopold IH (ed): Symposium on Ocular Therapy, p. 1. Mosby, St. Louis, 1974

    Google Scholar 

  5. Armaly MF: Inheritance of dexamethasone hypertension and glaucoma. Arch Ophthalmol 77:747, 1967

    PubMed  CAS  Google Scholar 

  6. Armaly MF: Ocular tolerance to silicones. Arch Ophthalmol 68:390, 1962

    PubMed  CAS  Google Scholar 

  7. Ashton N, Ward B, Serpell G: Role of oxygen in the genesis of retrolental fibroplasia. Br J Ophthalmol 37:513, 1953

    PubMed  CAS  Google Scholar 

  8. Babel J: Histologie der Cortison-Cataract. In: Böke W (ed): DOG Symp. 1972, p. 327. Bergmann, Munich, 1973

    Google Scholar 

  9. Babel J, Leuenberger PM: Ultrastrukturelle Veränderungen der Hornhaut nach Verschreibung gewisser Medikamente. Ber Dtsch Ophthalmol Ges 71:18, 1971

    Google Scholar 

  10. Baikoff G, Baikoff MD: Les cataractes medicamenteuses. Ann Oculist (Paris) 208:767, 1975

    Google Scholar 

  11. Barraquer J: Totale Linsenextraktion nach Auflösung der Zonula durch Alpha-Chymotrypsin-Enzymatische Zonulolyse. Klin Monatsol Augenheilkd 133:609, 1958

    CAS  Google Scholar 

  12. Beasley H, Fraunfelder TT: Retinal detachments and topical miotics. Symposium of Drugs 86:95, 1979

    CAS  Google Scholar 

  13. Becker B: Decrease in intraocular pressure in men by a carbonic anhydrase inhibitor “Diamox.” Am J Ophthalmol 37:13, 1954

    PubMed  CAS  Google Scholar 

  14. Becker B: The side effects of corticosteroids. Invest Ophthalmol 3:492, 1964

    PubMed  CAS  Google Scholar 

  15. Becker B, Hahn KA: Topical corticosteroids and heredity in primary open angle glaucoma. Am J Ophthalmol 57:543, 1964

    PubMed  CAS  Google Scholar 

  16. Bennett TO, Sugar J, Sahgal S: Ocular manifestations of toxic epidermal necrolysis associated with allopurinol use. Arch Ophthalmol 95:1362, 1977

    PubMed  CAS  Google Scholar 

  17. Benson H: Permeability of the cornea to topically applied drugs. Arch Ophthalmol 91:313, 1974

    PubMed  CAS  Google Scholar 

  18. Benton CC, Calhoun FP: The ocular effects of methyl alcohol poisoning (report of a catastrophe involving 320 persons). Am J Ophthalmol 36:1677, 1953

    PubMed  Google Scholar 

  19. Berkow I, Gills I, Wise I: Depigmentation of the eyelids after topically administered thiotepa. Arch Ophthalmol 82:415, 1969

    PubMed  CAS  Google Scholar 

  20. Bernstein HN: Ocular side-effects of drugs. In: Dikstein S (ed): Drugs and Ocular Tissue, p. 560. Karger, Basel, 1977

    Google Scholar 

  21. Bietti G, Virno M, Pecori-Giraldi J, Pellegrino N: Acetazolamide, metabolic acidosis, and intraocular pressure. Am J Ophthalmol 80:360, 1975

    PubMed  CAS  Google Scholar 

  22. Bigger JF: Retinal hemorrhages during penicillamine therapy of cystinuria. Am J Ophthalmol 66:954, 1968

    PubMed  CAS  Google Scholar 

  23. Black LR, Oglesby RB, Sallmann L von, Bunim JJ: Posterior subcapsular cataracts induced by corticosteroid in patients with rheumatoid arthritis. JAMA 174:166, 1960

    PubMed  CAS  Google Scholar 

  24. Bleckmann H: Die Wirkung von Dichlorphenamid beider Behandlung des akuten Glaukomanfalls. Graefes Arch Klin Exp Ophthalmol 201:69, 1976

    CAS  Google Scholar 

  25. Bock E: Die angeborenen Kolobome des Augapfels. Joseph Safar, Vienna, 1893

    Google Scholar 

  26. Bogdanoff B, Rorke LB, Yanoff M, Warren WV: Brain and eye abnormalities: possible sequelae to prenatal use of multiple drugs including LSD. Am J Dis Child 123:145, 1972

    PubMed  CAS  Google Scholar 

  27. Böke W, (ed): Kortikosteroide in der Augenheilkunde. In: Symposium der D.O.G., 1972. Bergmann, Munich, 1973

    Google Scholar 

  28. Böke W, Bäumer A, Müller-Limmroth M, Mludek M: Zur Frage der Chloroquinschädigung des Auges. Klin Monatsbl Augenheilkd 151:617, 1967

    PubMed  Google Scholar 

  29. Born AJ: Vortex patterns of the corneal epithelium. Trans Ophthalmol Soc UK 93:435, 1974

    Google Scholar 

  30. Brothers DM, Hidavat AA: Conjunctival pigmentation associated with tetracycline medication. Ophthalmology 88:1212, 1981

    PubMed  CAS  Google Scholar 

  31. Bullock JD, Albert D: Flecked retina: appearance secondary to oxalate crystals from methoxyflurane anaesthesia. Arch Ophthalmol 93:26, 1975

    PubMed  CAS  Google Scholar 

  32. Burstein NL, Klyce SD: Electrophysiologic and morphologic effects of ophthalmic preparations on rabbit cornea epithelium. Invest Ophthalmol 16:899, 1977

    CAS  Google Scholar 

  33. Casanovas J, Carbonell M: Malformaciones oculares en la embriopatia thalidomidica, Arch Soc Oftalmol Hisp Am 24:947, 1964

    Google Scholar 

  34. Chan CC, Fishman M, Egbert PR: Multiple ocular anomalies associated with maternal LSD ingestion. Arch Ophthalmol 96:282, 1978

    PubMed  CAS  Google Scholar 

  35. Caravella LP Jr, Burns JA, Zangmeister M: Punctal-canicular stenosis related to systemic fluorouracil therapy. Arch Ophthalmol 99:284, 1981

    PubMed  Google Scholar 

  36. Chiaramonte JS: Cycloplegia from transdermal scopolamine. N Engl J Med 306:174, 1982

    PubMed  CAS  Google Scholar 

  37. Cloud TM, Hakim R, Griffin C: Photosensitization of the eye with methoxsalen. I. Acute effects. Arch Ophthalmol 64:346, 1960

    PubMed  CAS  Google Scholar 

  38. Cloud TM, Hakim R, Griffin C: Photosensitization of the eye with methoxsalen. II. Chronic effects. Arch Ophthalmol 66:689, 1961

    PubMed  CAS  Google Scholar 

  39. Cogan DG, Truman JT, Smith TR: Optic neuropathy, chloramphenicol and infantile genetic agranulocytosis. Invest Ophthalmol 12:534, 1973

    PubMed  CAS  Google Scholar 

  40. Cohen DN: Intracranial hypertension and papilledema associated with nalidixic acid therapy. Am J Ophthalmol 76:680, 1973

    PubMed  CAS  Google Scholar 

  41. Coles WH: Pilocarpine toxicity: effects on the rabbit corneal endothelium. Arch Ophthalmol 93:36, 1975

    PubMed  CAS  Google Scholar 

  42. D’Amico DJ, Kenyon KR, Ruskin JN: Amiodarone keratopathy; drug-induced lipid storage disease. Arch Ophthalmol 99:257, 1981

    PubMed  Google Scholar 

  43. Davidson SI: Reported adverse effects of oral contraceptives on the eye. Trans Ophthalmol Soc UK 91:561, 1971

    PubMed  CAS  Google Scholar 

  44. Dawson WW: Cannabis and eye function. Invest Ophthalmol 15:243, 1976

    PubMed  CAS  Google Scholar 

  45. Reilingh AV, Reiners H, van Bijsterveld OP: Contact lens tolerance and oral contraceptives. Ophthalmology 10:947, 1978

    Google Scholar 

  46. Dikstein S: Drugs and Ocular Tissues. Karger, Basel, 1977

    Google Scholar 

  47. Domarus D von: Adrenochromeinlagerungen in die Kornea (“Schwarze Hornhaut”): Klinisch-pathologischer Fallbericht. Ophthalmologica 175:166, 1977

    PubMed  CAS  Google Scholar 

  48. Draeger J: Beitrag zur Frage des Cortison-Glaukoms. Wien Med Wochenschr 115:711, 1965

    PubMed  CAS  Google Scholar 

  49. Draeger J: Gezielte Elektrolytsubstitution bei langdauernder Behandlung mit Carboanhydrasehemmern. Ber Dtsch Ophthalmol Ges 64:411, 1961

    CAS  Google Scholar 

  50. Ellis Th: Occlusion of the central retinal artery after retrobulbar corticosteroid injection. Am J Ophthalmol 85:352, 1978

    PubMed  CAS  Google Scholar 

  51. Enoch JM: Retinal stretch and accommodation. In: Kaufman H, Zimmerman TI (eds): Currents Concepts in Ophthalmology, Vol. 5: p59. St. Louis CV Mosby, 1976

    Google Scholar 

  52. Fanta H: Gefässveränderungen im Augenhintergrund, verursacht durch Kontrazeptiva. Klin Monatsbl Augenheilkd 163:13, 1973

    PubMed  CAS  Google Scholar 

  53. Flynn JT, O’Grady GE, Herrera J, et al: Retrolental fibroplasia. I. Clinical observations. Arch Ophthalmol 95:217, 1977

    PubMed  CAS  Google Scholar 

  54. Fraunfelder FT, Meyer SM: Drug-induced ocular side effects and drug interactions, 2 ed. Philadelphia, Lea & Febiger, 1982

    Google Scholar 

  55. Fraunfelder FT, Meyer SM: Ocular toxicity of antineoplastic agents. Ophthalmology 90:1, 1983

    PubMed  CAS  Google Scholar 

  56. Fraunfelder FT, Hanna C, Dreis MW, et al: Cataracts associated with allopurinol therapy. Am J Ophthalmol 94:137, 1982

    PubMed  CAS  Google Scholar 

  57. François J: Corticosteriod glaucoma. Ann Ophthalmol 9:1075, 1977

    PubMed  Google Scholar 

  58. Garlikov RS, Chenoweth RG: Macular hole following topical pilocarpine. Ann Ophthalmol 7:1313, 1975

    PubMed  CAS  Google Scholar 

  59. Gass JDM: Nicotinic acid maculopathy. Am J Ophthalmol 76:500, 1973

    PubMed  CAS  Google Scholar 

  60. Glew WB: Determination of 8-methoxy psoralen in serum, aqueous and lens; relation to long-wave ultraviolet phototoxicity in experimental and clinical photochemotherapy. Trans Am Ophthalmol Soc 77:464, 1979

    PubMed  CAS  Google Scholar 

  61. Gnad HD: Über Pharmaka mit unerwünschten Nebenwirkungen auf die Netzhautgefässe. Klin Monatsbl Augenheilkd 167:604, 1975

    PubMed  CAS  Google Scholar 

  62. Gnädinger MC: Die Wirkung von Hydrokortison auf Epithelkulturen der Cornea. In: Böke W (ed): Corticosteroide in der Augenheilkunde. DOG Symposion 1972, p. 27. Bergmann, Munich, 1973

    Google Scholar 

  63. Gnädinger MC: Conjunctiva, cornea. In: Hockwin O, Koch HR (eds): Arzneimittel-Nebenwirkungen am Auge, p. 29. Fischer, Stuttgart, 1977

    Google Scholar 

  64. Godel V, Nemet P, Lazar M: Chloramphenicol optical neuropathy. Arch Ophthalmol 98:1417, 1980

    PubMed  CAS  Google Scholar 

  65. Grant WM: Toxicology of the Eye, ed. 2. Charles C Thomas, Springfield, IL, 1974

    Google Scholar 

  66. Grant WM, Trotter RR: Diamox (acetazoleamide) in treatment of glaucoma. Arch Ophthalmol 51:735, 1954

    CAS  Google Scholar 

  67. Green WR: Retinal and optic nerve atrophy induced by intravitreous vincristine in the primate. Trans Am Ophthalmol Soc 73:389, 1975

    PubMed  CAS  Google Scholar 

  68. Griffin JD, Garnick MB: Eye toxicity of cancer chemotherapy. Cancer 48:1539, 1981

    PubMed  CAS  Google Scholar 

  69. Havener WH: Ocular Pharmacology. Mosby, St. Louis, 1974

    Google Scholar 

  70. Heimann K, Kyrieleis E: Netzhautablösung bei miotischer Therapie. Klin Monatsbl Augenheilkd 156:98, 1970

    PubMed  CAS  Google Scholar 

  71. Hirst LW, Sanborn G, Green WR, et al: Amodiaquine ocular changes. Arch Ophthalmol 100:1300, 1982

    PubMed  CAS  Google Scholar 

  72. Hockwin O, Koch H-R: Arzneimittelnebenwirkungen am Auge. Fischer, Stuttgart, 1977

    Google Scholar 

  73. Hoffmann DH, Schmitz R: Die experimentelle Keratomykose als Beitrag zur Frage des Cortisonschadens am Auge. Ein vorläufiger Bericht. Mykosen 6:12, 1963

    PubMed  CAS  Google Scholar 

  74. Hollwich F, Jünemann G, Verbeck B: Über Nebenwirkungen der Ovulationshemmer am Netzhautvenensystem und am Sehnerv. Klin Monatsbl Augenheilkd 154:830, 1969

    PubMed  CAS  Google Scholar 

  75. Hommer K von, Bettelheim H: Occlusion of the central retinal artery following injection of embolizing material. Wien Klin Wochensch 90(21):777, 1978

    CAS  Google Scholar 

  76. Hornstein OP, Ruprecht KW: Fansidar-in-duced Stevens-Johnson syndrome. [Letter] N Engl J Med 307:1529, 1982

    PubMed  CAS  Google Scholar 

  77. Huismans H: Bilaterales (toxisches?) Papille-nödem bei Chloroquintherapie Wegen Pirmär Chronischer Polyarthritis. Klin Monatsol Augenheilkd 181:36, 1982

    CAS  Google Scholar 

  78. Jaeger W: Erworbene Farbensinnstörungen als Nebenwirkungen von Medikamenten. Klin Monatsbl Augenheilkd 170:453, 1977

    PubMed  CAS  Google Scholar 

  79. Jaensch PA: Augenschädigungen in Industrie und Gewerbe. Wiss. Verlagsgesellschaft, Stuttgart, 1958

    Google Scholar 

  80. Jones DB: Prospects in the management of tear-deficiency states. Trans Am Acad Ophthalmol Otolaryngol 83:693, 1977

    CAS  Google Scholar 

  81. Kagan J, Leopold IH: Drug-induced retinopathies. In: Leopold IH (ed): Symposium on Ocular Therapy, p. 116. Mosby, St. Louis, 1974

    Google Scholar 

  82. Kaiser-Kupfer MI, Rodrigues MM: Tamoxifen retinopathy; A clinicopathologic report. Ophthalmology 88:89, 1981

    PubMed  CAS  Google Scholar 

  83. Kaplan LJ, Capaert WE: Amiodarone keratopathy; Correlation to dosage and duration. Arch Ophthalmol 100:601, 1982

    PubMed  CAS  Google Scholar 

  84. Keltner JL, Roth AM, Chang RS: Photoreceptor degeneration: Possible autoimmune disorder. Arch Ophthalmol 101:564, 1983

    PubMed  CAS  Google Scholar 

  85. Kincaid MC, Green R, Hoover RE, et al: Ocular chrysiasis. Arch Ophthalmol 100:1791, 1982

    PubMed  CAS  Google Scholar 

  86. Kirsch RE: Glaucoma following cataract extraction associated with use of alpha-chymotrypsin. Arch Ophthalmol 72:612, 1964

    PubMed  CAS  Google Scholar 

  87. Kolker A, Becker B: Epinephrine maculopathy. Arch Ophthalmol 79:552, 1968

    PubMed  CAS  Google Scholar 

  88. Koniszewski G, Rix R, Brunner P: Histologische und elektronenmikroskopische Befunde an der Kaninchenretina nach Gabe von Vincristin. Graefes Arch Klin Exp Ophthalmol 199:147, 1976

    CAS  Google Scholar 

  89. Kroner B: Multiple ischemic infarctions in the retina and uvea due to cristalline corticosteroid embolisms following subcutaneous facial injections. Klin Monatsbl Augenheilkd 178:121, 1981

    PubMed  CAS  Google Scholar 

  90. Krupin T, Cross DA, Becker B: Decreased basal tear production associated with general anesthesia. Arch Ophthalmol 95:107, 1977

    PubMed  CAS  Google Scholar 

  91. Krüskemper HL: Wirkung und Nebenwirkung der Behandlung mit Glukokorticoiden. In: Böke W (ed): Kortikosteroide in der Augenheilkunde, p. 258. Bergmann, Munich, 1973

    Google Scholar 

  92. Kushner BJ, Essner D, Cohen IJ, Flynn JT: Ret-rolental fibroplasia. II. Pathologic correlation. Arch Ophthalmol 95:29, 1977

    PubMed  CAS  Google Scholar 

  93. Lenz W: Thalidomide in congenital abnormalities Lancet 1:45, 1962

    Google Scholar 

  94. Leopold IH (ed): Symposium on Ocular Therapy, Vol. VII. Mosby, St. Louis, 1974

    Google Scholar 

  95. Leuenberger PM: Ultrastrukturelle Veränderungen am Hornhautepithel nach Oberflàche-nanaesthesie. Graefes Arch Klin Exp Ophthalmol 186:73, 1973

    CAS  Google Scholar 

  96. Leydhecker W: Glaukom durch Steroide. In: Böke W (ed): Corticosteroide in der Augenheilkunde, p. 287. Bergmann, Munich, 1973

    Google Scholar 

  97. Leydhecker W: Sympathikomimetika und Sympathikolytika in der Glaukomtherapie. Klin Monatsbl Augenheilkd 171:538, 1977

    Google Scholar 

  98. Leydhecker W, Dardenne U: Histologische Untersuchungen am Trabekelsystem nach kurzfristiger Einwirkung von Alphachymotrypsin. Klin Monatsbl Augenheilkd 142:554, 1963

    PubMed  CAS  Google Scholar 

  99. Long SL de, Poley BI, McFarlane JR: Ocular changes associated with long term chlorpromazine therapy. Arch Ophthalmol 73:611, 1965

    Google Scholar 

  100. Lund O-E: Silikonöl als Glaskörperersatz. Ber Dtsch Ophthalmol Ges 68:166, 1968

    CAS  Google Scholar 

  101. Mabry RL: Visual loss after intranasal corticosteroid injection. Arch Otolaryngol 107:484, 1981

    PubMed  CAS  Google Scholar 

  102. Manschot WA: Intravitreal silicone injection. Adv Ophthalmol 36:197, 1978

    PubMed  CAS  Google Scholar 

  103. Maucher OM: Periorbitalekzem als iatrogene Erkrankung. Klin Monatsbl Augenheilkd 164:350, 1974

    PubMed  CAS  Google Scholar 

  104. Mayer U: Alterationen des Sehnerven und der Netzhaut bei innerlicher Gabe von Chloramphenicol. Klin Paediatr 186:447, 1974

    CAS  Google Scholar 

  105. Mayer U: Wirkung des Pilocarpins auf den Stoffwechsel von überlebenden Linsenepithelien und Irisgewebe. Klin Monatsbl Augen-heilkd 168:531, 1976

    CAS  Google Scholar 

  106. Mayer U, Dengler G: Vergleichende Untersuchungen über den Einfluss von Pilocarpin und Aceclidin auf den Glukoseverbrauch überlebender Augengewebe. Graefes Arch Klin Exp Ophthalmol 205:113, 1978

    CAS  Google Scholar 

  107. Mayer U, Schrott R: Cortison und Linsenepithel bzw. Irisgewebe. Graefes Arch Klin Exp Ophthalmol 198:101, 1976

    CAS  Google Scholar 

  108. McFarlane J, Yanoff M, Scheie HG: Toxic retinopathy secondary to sparsomycin therapy. Arch Ophthalmol 76:532, 1966

    PubMed  CAS  Google Scholar 

  109. McGregor IS: A study of the histopathological changes in the retina and late changes in the visual field in acute methyl alcohol poisoning. Br J Ophthalmol 27:523, 1943

    PubMed  CAS  Google Scholar 

  110. Meier-Ruge W: Medikamentöse Retinopathie. Thieme, Stuttgart, 1967

    Google Scholar 

  111. Meredith TA, Aaberg TM, Willerson WD: Progressive chorioretinopathy after receiving thioridazine. Arh Ophthalmol 96:1172, 1978

    CAS  Google Scholar 

  112. Miller FS, Bunt-Milam AH, Kalina RE: Clinical-ultrastructural study of thioridazine retinopathy. Ophthalmology 89:1478, 1982

    PubMed  Google Scholar 

  113. Meyner EM: Personal communication, 1975

    Google Scholar 

  114. Mooney D: Pigmentation after long-term topical use of adrenaline compounds. Br J Ophthalmol 54:823, 1970

    PubMed  CAS  Google Scholar 

  115. Moses RA (ed): Accommodation. In: Adler’s Physiology of the Eye: Clinical Application, ed. 5, p. 358. Mosby, St. Louis, 1970

    Google Scholar 

  116. Müller H: Histologische Untersuchung eines Auges bei akuter tödlicher Methylalkoholvergiftung. Klin Monatsbl Augenheilkd 116:135, 1950

    Google Scholar 

  117. Ni C, Wang WJ, Albert DM, et al: Intravitreous silicone injection; histopathologic findings in a human eye after 12 years. Arch Ophthalmol 101:1399, 1983

    PubMed  CAS  Google Scholar 

  118. Norn MS: Pemphigoid related to epinephrine treatment. Am J Ophthalmol 83:138, 1977

    PubMed  CAS  Google Scholar 

  119. Nover A, Koinis G: Arsenschädigung der Netzhaut. Klin Monatsbl Augenheilkd 150:535, 1967

    PubMed  CAS  Google Scholar 

  120. Ott G, Coster W de, Thiery E, et al: Ultrastructural study of muscle biopsy from a patient with subacute myelooptic neuropathy. J Neurol 215:91, 1977

    Google Scholar 

  121. Papst W: Thalidomid und kongenitale Anomalien der Augen. Ber Dtsch Ophthalmol Ges 65:209, 1964

    CAS  Google Scholar 

  122. Parrish JA, Fitzpatrick TB, Tanenbaum L, Pathak MA: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light. N Engl J Med 291:1207, 1974

    PubMed  CAS  Google Scholar 

  123. Patten JT, Cavanagh HD, Allansmith MR: Induced ocular pseudopemphigoid. Am J Ophthalmol 82:272, 1976

    PubMed  CAS  Google Scholar 

  124. Patz A: The effect of oxygen on immature retinal vessels. Invest Ophthalmol 4:988, 1965

    PubMed  CAS  Google Scholar 

  125. Pau H, Wahl M: Myambutol—Schädigung des Auges. Ber Dtsch Ophthalmol Ges 72:176, 1974

    CAS  Google Scholar 

  126. Pau H, Schmitt-Graff A: Pigmented deposits into conjunctiva after local application of epinephrine. Graefes Arch Klin Ophthalmol 216:69, 1981

    CAS  Google Scholar 

  127. Petursson GJ, Fraunfelder FT, Meyer SM: Oral contraceptives. Ophthalmology 88:368, 1981

    PubMed  CAS  Google Scholar 

  128. Potts AM: Further studies concerning the accumulation of polycyclic compounds on uveal melanin. Invest Ophthalmol 3:399, 1964

    PubMed  CAS  Google Scholar 

  129. Pouliquen Y, Graf B, Bisson J, et al: Etude ultrastructurale d’une surcharge cornéenne au cours d’un traitement par la chlorpromazine. Arch Ophtalmol (Paris) 30:769, 1970

    CAS  Google Scholar 

  130. Pülhorn G, Thiel H-J: Das ultrastrukturelle Bild der Chloroquin-Keratopathie. Graefes Arch Klin Exp Ophthalmol 201:89, 1976

    Google Scholar 

  131. Prouse PJ, Kanski JJ, Gumpel JM: Corneal chrysiasis and clinical improvement with chrysotherapy in rheumatoid arthritis. Ann Rheum Dis 40:564, 1981

    PubMed  CAS  Google Scholar 

  132. Pruett RC, Carvalho ACA, Trempe CL: Microhemorrhagic maculopathy. Arch Ophthalmol 99:425, 1981

    PubMed  CAS  Google Scholar 

  133. Rahi AHS, Chapman CM, Garner A, Wright P: Pathology of practolol-induced ocular toxicity. Br J Ophthalmol 60:321, 1976

    Google Scholar 

  134. Ramsey MS, Fine BS: Chloroquine toxicity in the human eye. Am J Ophthalmol 73:229, 1972

    PubMed  CAS  Google Scholar 

  135. Rauhut D, Rohen JW: Electron microscopic study of the trabecular meshwork in alphachymotrypsin glaucoma. Graefes Arch Klin Exp Ophthalmol 184:29, 1972

    CAS  Google Scholar 

  136. Reinecke RD, Kuwabara T: Corneal deposits secondary to topical epinephrine. Arch Ophthalmol 70:170, 1963

    PubMed  CAS  Google Scholar 

  137. Rens GH van, de Jong PT, Demols EE, et al: Uveal malignant melanoma and levodopa therapy in Parkinson’s disease. Ophthalmology 89:1464, 1982

    PubMed  Google Scholar 

  138. Ronnerfalt L, Lydahl E, Wennersten G, et al: Ophthalmological study of patients undergoing long-term puva therapy. Acta Derm Venereol (Stockh) 62:501, 1982

    CAS  Google Scholar 

  139. Rohen JW, Linner E, Witmer R: Electron microscopic studies on the trabecular meshwork in two cases of corticosteroid glaucoma. Exp Eye Res 17:19, 1973

    PubMed  CAS  Google Scholar 

  140. Roll P, Benedikt O: Electronmicroscopic investigation of the trabecular meshwork in cortisonglaucoma. Klin Monatsbl Augenheilkd 174:421, 1979

    PubMed  CAS  Google Scholar 

  141. Ruprecht KW, Loch E-G, Giere W: Sandgefühl der Augen und hormonale Kontrazeptiva. Klin Monatsbl Augenheilkd 168:198, 1976

    PubMed  CAS  Google Scholar 

  142. Sanderson PA, Kuwabara T, Cogan DG: Optic neuropathy presumably caused by vincristine therapy. Am J Ophthalmol 81:146, 1976

    PubMed  CAS  Google Scholar 

  143. Sawyer RA, Seihorst JB, Zimmerman LE, Hoyt WF: Blindness caused by photoreceptor degeneration as a remote effect of cancer. Am J Ophthalmol 81:606, 1976

    PubMed  CAS  Google Scholar 

  144. Schmidt D, Kommerell G: Okuläre Myasthenie durch D-Penicillamin-Behandlung. Klin Monatsbl Augenheilkd 168:409, 1976

    PubMed  CAS  Google Scholar 

  145. Schmidt J, Schmidt L: Studies of the neurotoxicity of ethambutol and its racemate for the rhesus monkey. J Neuropathol Exp Neurol 25:40, 1966

    Google Scholar 

  146. Skalka HW, Prhcal JT: Effect of corticosteriods on cataract formation. Arch Ophthalmol 98:1773, 1980

    PubMed  CAS  Google Scholar 

  147. Schmitt H, Remler O: Adrenochrome Bindehauteinschlüsse als Folge einer örtlichen Adrenalintherapie. Klin Monatsbl Augenheilkd 165:332, 1974

    PubMed  CAS  Google Scholar 

  148. Severin M: Keratoconjunctivitis sicca mit Bindehautschrumpfung während einer Behandlung mit Dalzic. Klin Monatsbl Augenheilkd 165:941, 1974

    PubMed  CAS  Google Scholar 

  149. Shapiro D: The ocular manifestations of the cannabinols. Ophthalmologica 168:366, 1974

    PubMed  CAS  Google Scholar 

  150. Souri EN, Green WR: Intravitreal amphotericin B toxicity. Am J Ophthalmol 78:77, 1974

    PubMed  CAS  Google Scholar 

  151. Sundmacher R, Alpers K: Corneal chalcosis from misuse of copper sulfate eye drops. Klin Monatsbl Augenheilkd 182:325, 1983

    PubMed  CAS  Google Scholar 

  152. Svarc ED, Werner D: Isolated retinal hemorrhages associated with oral contraceptives. Am J Ophthalmol 84:50, 1977

    PubMed  CAS  Google Scholar 

  153. Tarns G: Über die drucksenkende Wirkung von Glyzerin-Askorbat-Na. Klin Monatsbl Augenheilkd 158:663, 1971

    Google Scholar 

  154. Terry TL: Extreme prematurity and fibroplastic overgrowth of persistent vascular sheath behind each crystalline lens. Am J Ophthalmol 25:203, 1942

    Google Scholar 

  155. Trese M: Retinal hemorrhage caused by overdose of methaqualone (quaalude). Am J Ophthalmol 91:201, 1981

    PubMed  CAS  Google Scholar 

  156. Tillmann W, Keitel L: Hornhautveränderungen durch Indometacin (Amuno). Klin Monatsbl Augenheilkd 170:756, 1977

    PubMed  CAS  Google Scholar 

  157. Varga M: Recent experiences on the ophthalmologic complications of oral contraceptives. Ann Ophthalmol 8:925, 1976

    PubMed  CAS  Google Scholar 

  158. Verbeck B: Augenbefunde und Stoffwechselverhalten bei Einnahme von Ovulationshemmern. Klin Monatsbl Augenheilkd 162:612, 1973

    PubMed  CAS  Google Scholar 

  159. Vlaho M, Gross R: Plasma-Ersatzmittel und Plasma-Expander. Therapeutische Anwendung und Vorsichtsmassnahmen. Dtsch Ärzte-blatt 45:2859, 1976

    Google Scholar 

  160. Voe AG de: The cornea and systemic disease. In: Symposion on the Cornea, p. 30. Mosby, St. Louis, 1972

    Google Scholar 

  161. Vogt A: Beobachtungen am Spaltlampenmikroskop. Klin Monatsbl Augenheilkd 65:102, 1920

    Google Scholar 

  162. Walsh FB, Hoyt WF: Clinical Neuro-ophthal-mology, Vols. I-III. Williams & Wilkins, Baltimore, 1969

    Google Scholar 

  163. Weber U, Goerz G: Augenschaden durch Carotinoid-Einnahme. Deutsches Ärzteblatt 25:181, 1985

    Google Scholar 

  164. Welge-Lussen L von: Thalidomidembryo-pathie mit eigentümlichen Augenveränderungen. Klin Monatsbl Augenheilkd 178:372, 1971

    Google Scholar 

  165. Wennersteen G: Photoprotection of the eye in PUVA therapy. Br J Dermatol 98:137, 1978

    Google Scholar 

  166. Werry H, Brewitt H: Cataract following intravitreal SF6 injection. Klin Monstabl Augenheilkd 192:331, 1983

    Google Scholar 

  167. Williamson J, Dalakos TG: Posterior subcapsular cataracts and macula lesions after long time corticotrophin therapy. Br J Ophthalmol 51:839, 1967

    PubMed  CAS  Google Scholar 

  168. Wilson LA, McNatt J, Reitschel R: Delayed hypersensitivity to timerosal in soft contact lens wearers. Ophthalmology 88:804, 1981

    PubMed  CAS  Google Scholar 

  169. Wright P: Untoward effects associated with practolol administration: oculomucocutaneous syndrome. Br Med J 15:595, 1975

    Google Scholar 

  170. Wright P, Fraunfelder FT: Practolol-induced oculomucocutaneous syndrome. Symp Ocul Ther 9:97, 1976

    Google Scholar 

  171. Zelickson A: Skin changes and chlorpromazine: some hazards of long-term drug therapy. JAMA 198:341, 1966

    PubMed  CAS  Google Scholar 

  172. Zinn M: Iatrogenic intraocular injection of depot corticosteroid and its surgical removal using the pars plana approach. Ophthalmology 88:13, 1981

    PubMed  CAS  Google Scholar 

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© 1986 Springer-Verlag New York, Inc.

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Ruprecht, K.W., Naumann, G.O.H. (1986). Morphology of Drug-Induced Ocular Changes. In: Pathology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8525-7_17

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