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General Pathology of the Retina: Correlation of the Ophthalmoscopic Appearance with Tissue Morphology

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Pathology of the Eye
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Abstract

The concepts and terminology used in general pathology can be applied to both clinical ophthalmology and ophthalmic pathology. In a routine office practice one examines ocular diseases in vivo with magnifications similar to those used by the pathologist when examining microscopic sections. Clinical ophthalmoscopy can therefore be considered a form of microscopy of living tissues. It is the purpose of this chapter to correlate the ophthalmoscopic appearance of lesions with the specific tissue changes that lead to this appearance. The retina is susceptible to virtually all types of injury and disease that fall into the realm of general pathology (see Chapter 11).

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References

  1. Aaberg TM, Blair CJ, Gass JDM: Macular holes. Am J Ophthalmol 69:555, 1970

    PubMed  CAS  Google Scholar 

  2. Amalric PM: Choroidal vessel occlusive syndromes—clinical aspects. Trans Am Acad Ophthalmol Otolaryngol 77:291, 1973

    Google Scholar 

  3. Archer DB, Deutman A, Ernest JT, Krill AE: Arteriovenous communications of the retina. Am J Ophthalmol 75:224, 1973

    PubMed  CAS  Google Scholar 

  4. Arnold AC, Pepose JS, Helper RS, Foos RY: Retinal periphlebitis and retinitis in multiple sclerosis. I. Pathologic characteristics. Ophthalmology 91:255, 1984

    PubMed  CAS  Google Scholar 

  5. Ashton N: Oxygen and the growth and development of retinal vessels: in vivo and in vitro studies; the XX Francis I. Proctor lecture. Am J Ophthalmol 62:412, 1966

    PubMed  CAS  Google Scholar 

  6. Ashton N: Pathophysiology of retinal cottonwool-spots. Br Med Bull 26:143, 1970

    PubMed  CAS  Google Scholar 

  7. Ashton N: The eye in malignant hypertension. Trans Am Acad Ophthalmol Otolaryngol 76:17, 1972

    PubMed  CAS  Google Scholar 

  8. Ashton N, Addison DJ, Garner A: Degeneration of intramural pericytes in diabetic retinopathy. Br Med J 1:264, 1970

    Article  PubMed  Google Scholar 

  9. Ballantyne AJ, Michaelsen IC: Textbook of the Fundus of the Eye. Livingstone, London, 1970

    Google Scholar 

  10. Baurmann H, Meyer F, Oberhoff P: Komplikationen bei der arteriovenösen Anastomose der Netzhaut. Klin Monatsbl Augenheilkd 153:562, 1968

    PubMed  CAS  Google Scholar 

  11. Birrer L: Zur Histochemie der Natriumjodat-und Natriumjodazetat-Retinopathie. Ophthalmologica 160:176, 1970

    Article  PubMed  CAS  Google Scholar 

  12. Buettner H, Machemer R, Charles St, Anderson DR: Experimental deprivation of choroidal blood flow; retinal morphology, early receptor potential and electroretinography. Am J Ophthalmol 75:943, 1973

    PubMed  CAS  Google Scholar 

  13. Cogan DG, Kuwabara T: The sphingolipidoses and the eye. Arch Ophthalmol 79:437, 1968

    PubMed  CAS  Google Scholar 

  14. Cogan DG, Toussaint D, Kuwabara T: Retinal vascular patterns. IV. Diabetic retinopathy. Arch Ophthalmol 66:366, 1961

    PubMed  CAS  Google Scholar 

  15. Coscas G, Dhermy P: Occlusions Veneuses Retiniennes. Masson, Paris, 1978

    Google Scholar 

  16. Daicker B: Proliferative und degenerative Veränderungen von perivaskulärer Glia und Astroglia der Netzhaut. Klin Monatsbl Augenheilkd 153:697, 1968

    PubMed  CAS  Google Scholar 

  17. Daicker B: Retinochorioidale Venenanastomosen an der Ora serrata. Graefes Arch Klin Exp Ophthalmol 175:28, 1968

    Article  CAS  Google Scholar 

  18. Daicker B: Guggenheim R, Gywat L: Rasterelektronenmikroskopische Befunde an Netzhautflächen. III. Epivaskuläre Gliabüschel. Graefes Arch Klin Exp Ophthalmol 204:31, 1977

    Article  CAS  Google Scholar 

  19. Demeler U, Lüllwitz W: Erworbene chorioidale Gefässanastomosen. Ber Dtsch Ophthalmol Ges 73:431, 1975

    Google Scholar 

  20. Deutman AF: The Hereditary Dystrophies of the Posterior Role of the Eye. van Gorcum, Assen, 1971

    Google Scholar 

  21. Fankhauser F, Enoch J, Cibis P: Receptor orientation in retinal pathology. Am J Ophthalmol 52:767, 1961

    PubMed  CAS  Google Scholar 

  22. Fine BS, Yanoff M: Ocular Histology. Harper & Row, New York, 1975

    Google Scholar 

  23. Fine BS, Zimmerman LE: Müller cells and the “middle limiting membrane” of the human retina. Invest Ophthalmol 1:304, 1962

    PubMed  CAS  Google Scholar 

  24. Font RL, Naumann GOH: Ocular histopathology in pulseless disease. Arch Ophthalmol 82:784, 1969

    PubMed  CAS  Google Scholar 

  25. Foos RY: Anatomic and pathologic aspects of the vitreous body. Trans Am Acad Ophthalmol 77:171, 1973

    Google Scholar 

  26. François C, Neetens A, Trau S: Retinal micro-aneurysmata. Ophthalmologica 158:273, 1969

    Article  PubMed  Google Scholar 

  27. Frank RN, Green WR, Pollack IP: Senile macular degeneration: clinicopathologic correlations of a case in the predisciform stage. Am J Ophthalmol 63:573, 1967

    Google Scholar 

  28. Gass JDM: Choroidal neovascular membranes: their visualization and treatment. Trans Am Acad Ophthalmol Otolaryngol 77:310, 1973

    Google Scholar 

  29. Gass JDM: Pathogenesis of disciform detachment of the neuroepithelium I–VI. Am J Ophthalmol 63:573, 1967

    Google Scholar 

  30. Gloor B, Werner H: Postkoagulative und spontan auftretende internoretinale Fibroplasie mit Maculadegeneration. Klin Monatsbl Augenheilkd 151:822, 1967

    PubMed  CAS  Google Scholar 

  31. Gold DH, Francis G, LaPiana F, Zimmerman LE: Isolated retinal arterial aneurysms. Am J Ophthalmol 82:848, 1976

    PubMed  CAS  Google Scholar 

  32. Goldberg MF, Cotlier E: Macular cherry red spot, corneal clouding and galactosidase-deficiency. Arch Intern Med 128:387, 1971

    Article  PubMed  CAS  Google Scholar 

  33. Green WR, Gass DM: Senile disciform degeneration of the macula. Arch Ophthalmol 86:487, 1971

    PubMed  CAS  Google Scholar 

  34. Hayreh SS: Occlusion of the central retinal vessels. Br J Ophthalmol 49:626, 1965

    Article  PubMed  CAS  Google Scholar 

  35. Hayreh SS: Occlusion of the posterior ciliary arteries. Trans Am Acad Ophthalmol Otolaryngol 77:300, 1973

    Google Scholar 

  36. Hayreh SS, Baines JAB: Occlusion of the posterior ciliary artery. I. Effects on choroidal circulation. Br J Ophthalmol 56:719, 1972. II. Chorioretinal lesions. Br J Ophthalmol 56:736, 1972

    Article  PubMed  CAS  Google Scholar 

  37. Hoyt WF: Ocular symptoms and signs. In: Wylie EE, Ehrenfeld WK (eds): Extracranial Occlusive Cerebrovascular Disease, pp. 64–95. Saunders, Philadelphia, 1970

    Google Scholar 

  38. Hyvarinen L, Maumenee AE, George T, Weinstein GW: Fluorescein-angiography of the choriocapillaris. Am J Ophthalmol 67:653, 1969

    PubMed  CAS  Google Scholar 

  39. Lerche W: Vergleichende klinische und elektronenmikroskopische Befunde über während des Lebens auftretende Strukturveränderungen der Bruch’schen Membran am zentralen Augenhintergrund. Adv Ophthalmol 26:209, 1972

    Google Scholar 

  40. Lüllwitz W: Zur Klinik des Irvine-Gass-Syndromes. Ber Dtsch Ophthalmol Ges 73:561, 1975

    Google Scholar 

  41. Machemer R: Experimental retinal detachment in the owl monkey. II. Histology of retina and pigment epithelium. Am J Ophthalmol 66:396, 1968

    PubMed  CAS  Google Scholar 

  42. Machemer R: Experimental retinal detachment in the owl monkey. IV. The reattached retina. Am J Ophthalmol 66:1075, 1968

    PubMed  CAS  Google Scholar 

  43. Margherio RR, Schepens CL: Macular breaks. Am J Ophthalmol 74:219, 1972

    Google Scholar 

  44. Maumenee AE, Emery JM: An anatomic classification of diseases of the macula. Am J Ophthalmol 74:594, 1972

    Google Scholar 

  45. McPherson A (ed): New and Controversial Aspects of Retinal Detachment. Hoeber, New York, 1968

    Google Scholar 

  46. Meyer-Schwickerath G: Lichtkoagulation. Bücherei des Augenarztes. Enke, Stuttgart, 1959

    Google Scholar 

  47. Meyer-Schwickerath G: Maculaloch und Netzhautablösung. Ber Dtsch Ophthalmol Ges 64:249, 1961

    CAS  Google Scholar 

  48. Michels RG, Green WR, Maumenee AE: Cystoid macula edema following cataract extraction (the Irvine-Gass-syndrome). Ophthalmol Surg 2:217, 1971

    Google Scholar 

  49. Naumann GOH: Pigmentierte Naevi der Aderhaut und des Ciliarkörpers. Fortschr Ophthalmol 23:187, 1970

    CAS  Google Scholar 

  50. Naumann G, Hellner K, Naumann LR: Pigmented nevi of the choroid: clinical study of secondary changes in the overlying tissues. Trans Am Acad Ophthalmol Otolaryngol 75:110, 1971

    Google Scholar 

  51. Naumann GOH, Lüllwitz W: Allgemeine Pathologie der Maculaerkrankungen. Ber Dtsch Ophthalmol Ges 73:44, 1975

    Google Scholar 

  52. Newell FW: Choroidal folds. Am J Ophthalmol 75:930, 1973

    PubMed  CAS  Google Scholar 

  53. Newell FW, Krill AE, Farkas TG: Drusen and fundus flavimaculatus; clinical, functional and histologic characteristics. Trans Am Acad Ophthalmol 76:88, 1972

    CAS  Google Scholar 

  54. Noell WK, Walker VS, Rang BS, Berman S: Retinal damage by light in rats. Invest Ophthalmol 5:450, 1966

    PubMed  CAS  Google Scholar 

  55. Potts AM: An hypothesis on macular disease. Trans Am Acad Ophthalmol 70:1058, 1966

    CAS  Google Scholar 

  56. Rehsteiner K: Ophthalmoskopische Untersuchungen über Veränderungen der Fundus-Peripherie in myopen und senilen Augen. Graefes Arch Ophthalmol 120:282, 1928

    Article  Google Scholar 

  57. Rentsch FJ: Preretinal proliferation of glial cells after mechanical injury. Graefes Arch Klin Exp Ophthalmol 188:79, 1973

    Article  CAS  Google Scholar 

  58. Roth AM, Foos RY: Surface wrinkling retinopathy in eyes enucleated at autopsy. Trans Am Acad Ophthalmol Otolaryngol 75:1047, 1971

    PubMed  CAS  Google Scholar 

  59. Rutnin U, Schepens CL: Fundus appearance in normal eyes. II–III. Am J Ophthalmol 64:840, 1967

    PubMed  CAS  Google Scholar 

  60. Sautter H: Die Arteriosklerose des Augenhintergrundes. Klin Monatsbl Augenheilkd 127:641, 1955

    CAS  Google Scholar 

  61. Sautter H, Lüllwitz W, Naumann G: Die Infrarot-Photographie in der Differential-Diagnose pigmentierter tumorverdächtiger Fundusveränderungen. Klin Monatsbl Augenheilkd 164:597, 1974

    PubMed  CAS  Google Scholar 

  62. Sautter H, Utermann D: Der Pseudotumor der Macula. Klin Monatsbl Augenheilkd 145:1, 1964

    PubMed  CAS  Google Scholar 

  63. Schepens C, Brockhurst R. Uveal effusion. Arch Ophthalmol 70:189, 1963

    PubMed  CAS  Google Scholar 

  64. Seitz R: Die intraokularen Drusen. Klin Monatsbl Augenheilkd 152:203, 1968

    PubMed  CAS  Google Scholar 

  65. Seitz R: Klinik, Morphologie und Schicksal der Mikroaneurysmen. Klin Monatsbl Augenheilkd 158:539, 1971

    Google Scholar 

  66. Seitz R: Klinik und Pathologie der Netzhautgefässe. Enke, Stuttgart, 1968

    Google Scholar 

  67. Shakib M, Cunha-Vaz IG: Studies on the permeability of the blood-retinal-barrier. Exp Eye Res 5:229, 1966

    Article  PubMed  CAS  Google Scholar 

  68. Tarkkanen A, Vannas S: Ultrastructure of Bruch’s membrane in senile macular degeneration. Acta Ophthalmol (Copenk) 45:694, 1967

    Article  CAS  Google Scholar 

  69. Teeters VW, Bird AC: The development of neovascularization of senile disciform macular degeneration. Am J Ophthalmol 76:1, 1973

    PubMed  CAS  Google Scholar 

  70. Toussaint D, Dustin P: Electron microscopy of normal and diabetic retinal capillaries. Arch Ophthalmol 70:96, 1963

    PubMed  CAS  Google Scholar 

  71. Tso MOM, Fine BS, Zimmerman LE: Photic maculopathy by the indirect ophthalmoscope. 1. Clinical and histopathologic study. Am J Ophthalmol 73:686, 1972

    CAS  Google Scholar 

  72. Tso MOM, Wallow IHL, Powell JO: Differential susceptibility of rod and cone cells to argon laser. Arch Ophthalmol 89:228, 1973

    PubMed  CAS  Google Scholar 

  73. Tso MOM, Wallow IHL, Powell JO, Zimmerman LE: Recovery of the rod and cone cells after photic injury. Trans Am Acad Ophthalmol Otolaryngol 76:1247, 1972

    CAS  Google Scholar 

  74. Vogt A: Die operative Therapie und die Pathogenese der Netzhautablösung. Enke, Stuttgart, 1936

    Google Scholar 

  75. Wessing A: Changing concepts of central serous retinopathy and its treatment. Trans Am Acad Ophthalmol 77:275, 1973

    Google Scholar 

  76. Wessing A: Fluoreszenz-Angiographie der Retina. Thieme, Stuttgart, 1968

    Google Scholar 

  77. Wise G: Clinical features of idiopathic preretinal macular fibrosis. Am J Ophthalmol 79:349, 1975

    PubMed  CAS  Google Scholar 

  78. Wise GN, Dollery CT, Henkind P: The Retinal Circulation. Harper & Row, New York, 1971

    Google Scholar 

  79. Wollensak J: Radiäre Faltenbildung im Bereich der Makula. Ber Dtsch Ophthalmol Ges 73:141, 1975

    Google Scholar 

  80. Wolter JR: Pathology of Henle’s fibre layer. Br J Ophthalmol 51:169, 1967

    Article  PubMed  CAS  Google Scholar 

  81. Wolter JR: The cytoid body reaction of the human retina. Trans Am Ophthalmol Soc 65:106, 1967

    PubMed  CAS  Google Scholar 

  82. Wolter JR, Lund OE: Reaction of centrifugal nerves in the human retina two weeks after photocoagulation. Trans Am Ophthalmol Soc 66:173, 1968

    PubMed  CAS  Google Scholar 

  83. Young RW: The removal of photoreceptor cell outer segments. J Cell Biol 33:61, 1967

    Article  PubMed  CAS  Google Scholar 

  84. Zimmerman LE: Embolism of central retinal artery. Arch Ophthalmol 73:822, 1965

    PubMed  CAS  Google Scholar 

  85. Zimmerman LE: Problems in the diagnosis of malignant melanomas of the choroid and ciliary body. Am J Ophthalmol 75:917, 1973

    PubMed  CAS  Google Scholar 

  86. Zimmerman LE, Naumann G: Pathology of retinoschisis. In: McPherson A (ed): New and Controversial Aspects of Retinal Detachment, pp. 400–423. Hoeber, New York, 1968

    Google Scholar 

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Naumann, G.O.H., Lüllwitz, W. (1986). General Pathology of the Retina: Correlation of the Ophthalmoscopic Appearance with Tissue Morphology. In: Pathology of the Eye. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8525-7_12

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  • DOI: https://doi.org/10.1007/978-1-4613-8525-7_12

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8527-1

  • Online ISBN: 978-1-4613-8525-7

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