Introduction and General Overview
It has become increasingly clear that postreplication modification of DNA is relevant to many fields that at first glance may not seem related. Some knowledge of DNA modification is necessary to understand, to teach, or to experiment in the fields of bacterial genetics, prokaryotic gene regulation, recombinant DNA and molecular cloning, eukaryotic gene regulation, developmental biology, and (probably) cancer. During the last 10 years, a large body of information has been accumulated on enzymatic DNA modification, both in prokaryotes and eukaryotes. We thought it might be useful to bring all of this information together in one book, because the field of DNA methylation has become so large that searching the original literature has become a formidable task. In the past, cross-fertilization between studies on prokaryotes and eukaryotes has occurred in the methylation field. We hope this book will stimulate some additional cross-fertilization. No attempt will be made to discuss the evolution of the DNA methylation field from an historical perspective. However, to a certain extent, this is done in some of the chapters; also, the following list of recent reviews and some earlier key papers will serve to chronicle the development of the field.
KeywordsMethylation Pattern Methylase Activity Prog Nucleic Acid Eukaryotic Gene Regulation Unmethylated Site
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