Suppression of Aromatase Activity in Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in women of childbearing age. Estimates of incidence based on ultrasound scans of normal populations suggest that up to 23% of normal women may have polycystic ovaries (1); however, not all of these women are anovulatory or require medical treatment. The majority of the women with ultrasound evidence of PCOS have irregular menstrual cycles (75%) and 75% of the women with regular cycles are hirsute. This is in contrast to the women with normal ovaries (no ultrasound evidence of polycystic ovaries) of whom only.9% have irregular cycles (2). Within the infertile population, approximately three quarters of women with anovulatory infertility have PCO, thus accounting for approximately one third of women with secondary amenorrhea and approximately 90% of women with oligomenorrhea (3). Clearly PCOS affects a large number of women and is associated with menstrual irregularities in a large proportion of women.
KeywordsLuteinizing Hormone Granulosa Cell Polycystic Ovary Polycystic Ovary Syndrome Follicular Fluid
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