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Polycystic Ovary Syndrome pp 196–207Cite as

Development of Human Granulosa Cell Lines

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Ovarian granulosa cells play an essential role in the maturation of the developing ovum and in the synthesis of progesterone and estradiol. Granulosa cells of human origin are, however, difficult to obtain in sufficient numbers to accomplish detailed studies on the regulation of genes involved in granulosa cell division and hormone synthesis. Moreover, the granulosa cells that are readily available from women undergoing in vitro fertilization are in the process of differentiating into luteal cells. A culture system in which large numbers of functional cells can be propagated is a prerequisite for studying the molecular mechanisms controlling the expression of these proteins. In primary cultures of human granulosa (HG) cells it has proven particularly difficult to conduct molecular research due to the availability of only limited numbers of cells.

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Authors
  1. William E. Rainey
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  2. Tina C. Lavranos
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  3. Ann M. Corbould
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  4. Ray J. Rodgers
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  5. Bruce R. Carr
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, School of Medicine, University of California, Davis, 95816, Sacramento, CA, USA

    R. Jeffrey Chang M.D.

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© 1996 Springer-Verlag New York, Inc.

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Rainey, W.E., Lavranos, T.C., Corbould, A.M., Rodgers, R.J., Carr, B.R. (1996). Development of Human Granulosa Cell Lines. In: Chang, R.J. (eds) Polycystic Ovary Syndrome. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8483-0_13

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  • DOI: https://doi.org/10.1007/978-1-4613-8483-0_13

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4613-8485-4

  • Online ISBN: 978-1-4613-8483-0

  • eBook Packages: Springer Book Archive

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