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Optic Atrophy in Children

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Book cover Pediatric Neuro-Ophthalmology

Abstract

Optic atrophy is a morphologic sequelae to a multitude of anterior visual pathway insults that culminate in loss of retinal ganglion cell axons.153,185,200 Histopathologically, it is characterized by a variable reduction of nerve diameter with loss of axons and little or no gliosis. Ophthalmoscopically, the disc retains its normal size and shows diffuse or segmental pallor. The pallor in optic atrophy has been attributed to thinning of the neural tissue of the optic disc and resulting changes in cytoarchitecture and decreased transmission of light , rather than to loss of optic disc capillaries or astrocytic proliferation. 184,186 The ophthalmoscopic appearance of the atrophic disc alone only occasionally suggests a specific mechanism of injury.237

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Authors and Affiliations

  1. Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    Michael C. Brodsky MD (Associate Professor of Ophthalmology and Pediatrics, Chief of Pediatric Ophthalmology)

  2. Arkansas Children’s, Hospital Little Rock, Arkansas, USA

    Michael C. Brodsky MD (Associate Professor of Ophthalmology and Pediatrics, Chief of Pediatric Ophthalmology)

  3. University of Kentucky Medical Center, Lexington, Kentucky, USA

    Robert S. Baker MD (Chairman and Professor of Ophthalmology Professor of Pediatrics, Neurosurgery, and Neurology)

  4. Section of Pediatric Ophtalmology, University of Florida College of Medicine, Gainesville, Florida, USA

    Latif M. Hamed MD, FACS (Associate Professor of Ophthalmology and Pediatrics Chief)

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Brodsky, M.C., Baker, R.S., Hamed, L.M. (1996). Optic Atrophy in Children. In: Pediatric Neuro-Ophthalmology. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8457-1_4

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