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Flow Modulation of Receptor Function in Leukocyte Adhesion to Endothelial Cells

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Cell Mechanics and Cellular Engineering

Abstract

Proper function of the immune system depends on the accurate localization and recirculation of leukocytes throughout the body. This leukocyte homing is important in physiological processes such as neutrophil accumulation at sites of infection and lymphocyte recirculation through the blood and lymphatics. It is also important in pathological processes such as neutrophil-mediated myocardial reperfusion injury and the accumulation of monocytes at atherosclerotic lesions. All of the various localization processes have in common the specific, receptor-mediated adhesion of a particular population of leukocytes to a particular area of vascular endothelium, and a thorough understanding of this adhesion has great potential to allow development of useful new medications. Research in this area is complicated by the large number of receptors involved and the differential regulation of their expression on particular cell subpopulations. An extremely important additional complication arises from the fact that these interactions occur within the flowing bloodstream. Research on the effect of flow on leukocyte adhesion to vascular endothelium has revealed that different types of receptors are capable of mediating distinct types of adhesive events, such as initial rolling of leukocytes along the endothelium or later firm adhesion of leukocytes.

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Authors
  1. D. A. Jones
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  2. C. W. Smith
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  3. L. V. McIntire
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Editor information

Editors and Affiliations

  1. Orthopaedic Research Laboratory, Columbia University, 630 W. 168th Street, New York, NY, 10032, USA

    Van C. Mow

  2. Department of Aerospace Engineering, Mechanics and Engineering Science, University of Florida, Gainesville, FL, 32611, USA

    Roger Tran-Son-Tay

  3. Musculo-Skeletal Research Laboratory, Department of Orthopaedics, Health Science Center, State University of New York, Stony Brook, NY, 11794, USA

    Farshid Guilak

  4. Department of Mechanical Engineering and Material Sciences, Duke University, Durham, NC, 27708, USA

    Robert M. Hochmuth

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Jones, D.A., Smith, C.W., McIntire, L.V. (1994). Flow Modulation of Receptor Function in Leukocyte Adhesion to Endothelial Cells. In: Mow, V.C., Tran-Son-Tay, R., Guilak, F., Hochmuth, R.M. (eds) Cell Mechanics and Cellular Engineering. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8425-0_6

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