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Modeling Mechanical-Electrical Transduction in the Heart

  • F. Sachs

Abstract

The rate and rhythm of the heart is sensitive to mechanical deformation. As early as 1915, Bainbridge reported that distention of the atria produced an increase in heart rate (Bainbridge, 1915). Later studies showed that stretching alters action potential configuration (Dudel and Trautwein, 1954; Rosen et al. 1981; Dean and Lab, 1989; Lab, 1980; Taggart et al. 1992c; Taggart et al. 1992a; Taggart et al. 1992b; White et al. 1993), cause quiescent tissue to become spontaneously active and cause the generation of extra systoles (Hansen et al. 1990; Rajala et al. 1990; Stacy, Jr. et al. 1992; Sideris et al. 1990; Sideris et al. 1989; Hansen et al. 1991).

Keywords

Sarcomere Length Action Potential Amplitude Action Potential Shape Maximum Diastolic Potential Chick Skeletal Muscle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer-Verlag New York, Inc. 1994

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  • F. Sachs

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